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The Nanoscience of Polyvalent Binding by Proteins in the Immune Response

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Nanomedicine

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

Recent research has demonstrated that the successful use of nanometer-scaled material, such as nanoparticles, as medicines is often challenged by the host immune system. Mechanisms of the innate immunity seem to provide a swift response to administration of particulate nanomedicines, which may clear or in other way incapacitate the function of these drugs. To rationalize, why and how, the innate immune system especially interacts with nanomedicines, this chapter points to the prominent role of polyvalent interactions by large, immunoactive proteins with the surfaces of nanoparticles. From addressing the thermodynamics and ultrastructural properties of these interactions, it is proposed that the nm-scaled ligand presentation and symmetry on such surfaces is a determinant in the binding of these proteins. Better control over nanomedicine ultrastructure is consequently likely to provide important ways of regulating the interactions, wanted or unwanted, with the innate immune system.

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Acknowledgements

This paper summarizes ideas presented earlier as part of a public defense on September 5th 2014 for the degree of Doctor Medical Science awarded to TV-J. I would like to thank the official opponents on that occasion, Prof. Søren Buus, University of Copenhagen, Dr. A. Christy Hunter, Manchester Pharmacy School, and Prof. Kristian Stengaard-Pedersen, Aarhus University, for their helpful discussion and contributions to developing my thoughts on this topic. Our original papers were made with generous financial support from The Danish Multiple Sclerosis Association, The Danish Rheumatism Association, The Carlsberg Foundation, The Novo Nordisk Foundation, The Lundbeck Foundation, The LEO Pharma Research Foundation, The Danish Council for Independent Research|Medical Sciences, and The Danish Council for Independent Research| Natural Sciences.

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Authors and Affiliations

  1. Department of Biomedicine, Biophysical Immunology Laboratory, Aarhus University, Aarhus C, Denmark

    Thomas Vorup-Jensen M.Sc., Ph.D., D.M.Sc.

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  1. Thomas Vorup-Jensen M.Sc., Ph.D., D.M.Sc.
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Correspondence to Thomas Vorup-Jensen M.Sc., Ph.D., D.M.Sc. .

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Editors and Affiliations

  1. Department of Molecular Biology and Gen, Interdisciplinary Nanoscience Center (i, Aarhus, Denmark

    Kenneth A. Howard

  2. Department of Biomedicine, Biophysical I, Aarhus University, Aarhus, Denmark

    Thomas Vorup-Jensen

  3. Britannia Bldg, 2nd Fl, Rm 226, Tel-Aviv Univ, Dept Cell Research, Tel-Aviv, Israel

    Dan Peer

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Vorup-Jensen, T. (2016). The Nanoscience of Polyvalent Binding by Proteins in the Immune Response. In: Howard, K., Vorup-Jensen, T., Peer, D. (eds) Nanomedicine. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3634-2_4

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