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Fetal Stem Cell Banking

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Fetal Stem Cells in Regenerative Medicine

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Fetal stem/stromal cells can be isolated from various tissues and fluids including fetal blood, hematopoietic and somatic organs, amniotic fluid, and placenta. Fetal stem cells are emerging as a potential autologous and allogeneic cell source for several therapeutic applications in the field of cell therapy and regenerative medicine. While ageing of stem cells is not well understood, fetal stem/stromal cells are believed to have higher potential of growth and differentiation compared to their adult counterparts. The substantial advancements of cell banking have provided significant contribution to the rapid applications of cell therapy. Yet, the manufacturing of clinical grade fetal stem cells remains a hindrance due to the lack of a safe and effective cryopreservation compliant with good manufacturing practice for these cells. Whether fetal stem/stromal cells are to be used as an autologous or allogeneic cell therapy approach, therapeutic applications and outcomes are highly dependent on the long term ability to preserve these cells and maintain their viability and biological functions. The focus of this review is to discuss stem cells isolated from different fetal tissues and fluids, their cryopreservation approaches, and the commercial and regulatory aspects of these cells for therapeutic applications.

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  1. Cook General Biotechnology, LLC, 1102 Indiana Ave, Indianapolis, IN, 46202, USA

    Mohammad Z. Albanna Ph.D. & Erik J. Woods Ph.D.

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  1. Mohammad Z. Albanna Ph.D.
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  2. Erik J. Woods Ph.D.
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  1. Department of Surgery, Childrens Hosp Boston & Harvard Med, Boston, Massachusetts, USA

    Dario O. Fauza

  2. Department of Cellular and Molecular Med, University of Ottawa, Faculty of Medicin, OTTAWA, Ontario, Canada

    Mahmud Bani

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Albanna, M.Z., Woods, E.J. (2016). Fetal Stem Cell Banking. In: Fauza, D., Bani, M. (eds) Fetal Stem Cells in Regenerative Medicine. Stem Cell Biology and Regenerative Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3483-6_16

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