Abstract
Advances in nanotechnology have led to the fabrication of nano-constructs of organic or inorganic origins with well-defined structures, surface properties, and can be made to respond to physical or chemical stimuli. These nano-constructs can provide a shift in the way diagnostic and therapeutic drugs are delivered to achieve target specificity and increased retention of therapeutic doses for considerable improvement in the overall treatment of the tumors. In this case we describe here a synthetic approach to glycopolymer base nanoparticle gold(I) conjugate for cancer therapy.
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References
Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57–70
Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2013) Cancer incidence and mortality worldwide: IARC cancer base No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; GLOBOCAN 2012 v 1.0
Bray F, Ren JS, Masuyer E, Ferlay J (2013) Global estimates of cancer prevalence for 27 sites in the adult population. Int J Cancer 132:1133–1145
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. Cancer J Clin 61:69–90
Viani GA, Pellizzon AC, Guimaraes FS, Jacinto AA, Dos Santos Novaes PE, Salvajoli JV (2009) High dose rate and external beam radiotherapy in locally advanced prostate cancer. Am J Clin Oncol 32:187–190
Yoshioka Y (2009) Current status and perspectives of brachytherapy for prostate cancer. Int J Clin Oncol 1:31–16
Wang Z, Sun Y (2010) Targeting p53 for novel anticancer therapy. Transl Oncol 3:1–12
Ahmed M, Narain R (2013) Applications of bioconjugates. Chem Bioconjug Appl Bioconjug: 444–456
Chang CW, Bays E, Tao L, Alconel SNS, Maynard HD (2009) Differences in cytotoxicity of poly(PEGA)s synthesized by reversible addition-fragmentation chain transfer polymerization. Chem Commun 24:3580–3582
Deng Z, Li S, Jiang X, Narain R (2009) Well-defined galactose-containing multi-functional copolymers and glyconanoparticles for biomolecular recognition processes. Macromolecules 42:6393–6405
Narain R, Armes SP (2002) Synthesis of low polydispersity, controlled chemistry. Chem Commun 23:2776–2777
Narain R, Armes SP (2003) Direct synthesis and aqueous solution properties of well-defined cyclic sugar methacrylate polymers. Macromolecules 36:4675–4678
Narain R, Armes SP (2003) Synthesis and aqueous solution properties of novel sugar methacrylate-based homopolymers and block copolymers. Biomacromolecules 4:1746–1758
Ahmed M, Narain R (2012) The effect of molecular weight, compositions and lectin type on the properties of hyperbranched glycopolymers as non-viral gene delivery systems. Biomaterials 33:3990–4001
Ahmed M, Deng Z, Liu S, Lafrenie R, Kumar A, Narain R (2009) Cationic glyconanoparticles: their complexation with DNA, cellular uptake, and transfection efficiencies. Bioconjug Chem 20:2169–2176
Wilson-Welder JH, Torres MP, Kipper MJ, Mallapragada SK, Wannemuehler MJ, Narasimhan B (2009) Vaccine adjuvants: current challenges and future approaches. J Pharm Sci 98:1278–1316
Ahmed M, Mamba S, Yang X-H, Darkwa J, Kumar P, Narain R (2013) Synthesis and evaluation of polymeric gold glyco-conjugates as anti-cancer agents. Bioconjug Chem 24:979–986
Adokoh CK, Quan S, Hitt M, Darkwa J, Kumar P, Narain R (2014) Synthesis and evaluation of glycopolymeric decorated gold nanoparticles functionalized with gold-triphenyl phosphine as anti-cancer agents. Biomacromolecules 15:3802–3810
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Adokoh, C.K., Darkwa, J., Narain, R. (2016). Synthetic Approach to Glycopolymer Base Nanoparticle Gold(I) Conjugate: A New Generation of Therapeutic Agents. In: Sun, XL. (eds) Macro-Glycoligands. Methods in Molecular Biology, vol 1367. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3130-9_13
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DOI: https://doi.org/10.1007/978-1-4939-3130-9_13
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-3129-3
Online ISBN: 978-1-4939-3130-9
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