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The Sheep as a Model of Brain Injury in the Premature Infant

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Animal Models of Neurodevelopmental Disorders

Part of the book series: Neuromethods ((NM,volume 104))

Abstract

Preterm fetal sheep preparations provide unique experimental access to the complex pathophysiological processes that contribute to injury to the human brain during successive periods in development. Recent refinements have resulted in preparations that offer a number of significant advantages to model key aspects of human preterm cerebral injury. We describe a global cerebral ischemia preparation that replicates major features of acute and chronic human cerebral injury and which has provided access to complex clinically relevant studies of cerebral blood flow and neuro-imaging that are not feasible in smaller laboratory animals. Despite the higher costs and technical challenges of instrumented preterm fetal sheep models, they allow an integrated analysis of the spectrum of insults that appear to contribute to cerebral injury in human preterm infants.

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Acknowledgments

Supported by the National Institutes of Neurological Diseases and Stroke: 1RO1NS054044, R37NS045737-06S1/06S2 to SAB and 1F30NS066704 to AR, the American Heart Association (SAB) and the March of Dimes Birth Defects Foundation (SAB).

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Authors and Affiliations

  1. Departments of Pediatrics, BRB-353A, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239-3098, USA

    Art Riddle

  2. Pediatric Neuroscience, Oregon Health & Science University, Portland, OR, USA

    Art Riddle

  3. Department of Obstetrics and Gynecology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239-3098, USA

    A. Roger Hohimer

  4. Maternal and Fetal Medicine, Oregon Health & Science University, Portland, OR, USA

    A. Roger Hohimer

  5. Neuroscience Section, Pape’ Family Pediatric Research Institute, Oregon Health and Science University, Biomedical Research Building 317 3181 S.W. Sam Jackson Park Road, Portland, OR, 97239-3098, USA

    Stephen A. Back M.D., Ph.D.

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  3. A. Roger Hohimer
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Correspondence to Stephen A. Back M.D., Ph.D. .

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Editors and Affiliations

  1. Div. Pediatric Neurology, University of Alberta Dept. Pediatrics, Edmonton, Alberta, Canada

    Jerome Y. Yager

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© 2015 Springer Science+Business Media New York

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Back, S.A., Riddle, A., Hohimer, A.R. (2015). The Sheep as a Model of Brain Injury in the Premature Infant. In: Yager, J. (eds) Animal Models of Neurodevelopmental Disorders. Neuromethods, vol 104. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2709-8_8

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  • DOI: https://doi.org/10.1007/978-1-4939-2709-8_8

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2708-1

  • Online ISBN: 978-1-4939-2709-8

  • eBook Packages: Springer Protocols

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