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Experimental Models of High Fat Obesity and Leucine Supplementation

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Branched Chain Amino Acids in Clinical Nutrition

Part of the book series: Nutrition and Health ((NH))

Abstract

Obesity, the most common nutritional disorders, affects the majority of adults in Western society. It has become a leading health concern due to its link to insulin resistance, diabetes, and cardiovascular disease. Traditionally, prevention and treatment of obesity mainly depend on caloric restriction and increasing physical activity. Although short-term weight loss can be achieved by various dietary approaches, sustainability of weight loss seems to be difficult. Recently, several studies have shown that dietary manipulation of essential amino acids, including leucine, arginine, and glutamine, improves lipid and glucose metabolism. Specifically, dietary supplementation of leucine prevents HFD-induced obesity, mitochondrial dysfunction, and insulin resistance, suggesting the potential importance of dietary supplementation of leucine in the prevention of HFD-induced metabolic disorders. In this article, we review the metabolic roles of leucine and explore the underlying mechanisms by which leucine supplementation ameliorates HFD-induced metabolic disorders.

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Authors and Affiliations

  1. Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, 941 Stanton L Young Blvd. Basic Science Education Building 302B, Oklahoma City, OK, 73104, USA

    Yuran Xie B.S. & Zhonglin Xie M.D., Ph.D.

Authors
  1. Yuran Xie B.S.
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  2. Zhonglin Xie M.D., Ph.D.
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Correspondence to Zhonglin Xie M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Intensive Care, Barnet and Chase Farm Hospitals, Royal Free London NHS Foundation Trust, London, United Kingdom

    Rajkumar Rajendram

  2. Diabetes and Nutritional Sciences, Kings College London, London, United Kingdom

    Victor R. Preedy

  3. Department of Biomedical Sciences, University of Westminster, London, United Kingdom

    Vinood B. Patel

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Xie, Y., Xie, Z. (2015). Experimental Models of High Fat Obesity and Leucine Supplementation. In: Rajendram, R., Preedy, V., Patel, V. (eds) Branched Chain Amino Acids in Clinical Nutrition. Nutrition and Health. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1923-9_18

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  • DOI: https://doi.org/10.1007/978-1-4939-1923-9_18

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1922-2

  • Online ISBN: 978-1-4939-1923-9

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