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Computer Simulations of Phase Separation in Lipid Bilayers and Monolayers

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Methods in Membrane Lipids

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1232))

Abstract

Studying phase coexistence in lipid bilayers and monolayers is important for understanding lipid–lipid interactions underlying lateral organization in biological membranes. Computer simulations follow experimental approaches and use model lipid mixtures of simplified composition. Atomistic simulations give detailed information on the specificity of intermolecular interactions, while coarse-grained simulations achieve large time and length scales and provide a bridge towards state-of-the-art experimental techniques. Computer simulations allow characterizing the structure and composition of domains during phase transformations at Angstrom and picosecond resolution, and bring new insights into phase behavior of lipid membranes.

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Acknowledgements

This work was supported by the Natural Sciences and Engineering Research Council (Canada). DPT is an Alberta Innovates Health Solutions Scientist and Alberta Innovates Technology Futures Strategic Chair in (Bio)Molecular Simulation.

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  1. Department of Biological Sciences, Centre for Molecular Simulation, University of Calgary, 2500 University Dr. NW, Calgary, AB, Canada, T2N 1N4

    Svetlana Baoukina & D. Peter Tieleman

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  1. Svetlana Baoukina
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  2. D. Peter Tieleman
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Correspondence to Svetlana Baoukina .

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  1. Department of Physics and Randall Division of Cell and Molecular Biophysics, King’s College London, London, United Kingdom

    Dylan M. Owen

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© 2015 Springer Science+Business Media New York

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Baoukina, S., Tieleman, D.P. (2015). Computer Simulations of Phase Separation in Lipid Bilayers and Monolayers. In: Owen, D. (eds) Methods in Membrane Lipids. Methods in Molecular Biology, vol 1232. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1752-5_21

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  • DOI: https://doi.org/10.1007/978-1-4939-1752-5_21

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1751-8

  • Online ISBN: 978-1-4939-1752-5

  • eBook Packages: Springer Protocols

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