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Liver Magnetic Resonance Elastography Technique

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Magnetic Resonance Elastography

Abstract

Mechanical properties are promising surrogates for monitoring and characterizing various pathophysiologic conditions of cells and tissues. The mechanical properties of liver tissue are strongly correlated with the extent of fibrosis, and perhaps with increased hepatic vascular resistance and the associated increase of portal venous pressure. With recent advances in biomedical imaging, the ability to quantify in vivo liver stiffness with the development of MR elastography (MRE) is beginning to see widespread clinical use for assessing hepatic fibrosis as an alternative to biopsy. In this chapter, we will introduce the practical in vivo hepatic MRE technique for clinical investigations in humans, which is the culmination of technology development and optimization involving driver design (generating shear waves in the liver), pulse sequence design, imaging parameters, inversion algorithms, and image analyses.

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Authors and Affiliations

  1. Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA

    Meng Yin Ph.D., Armando Manduca Ph.D. & Roger C. Grimm

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  1. Meng Yin Ph.D.
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  2. Armando Manduca Ph.D.
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  3. Roger C. Grimm
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Correspondence to Meng Yin Ph.D. .

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Editors and Affiliations

  1. Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA

    Sudhakar K. Venkatesh

  2. Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA

    Richard L. Ehman

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Yin, M., Manduca, A., Grimm, R.C. (2014). Liver Magnetic Resonance Elastography Technique. In: Venkatesh, S., Ehman, R. (eds) Magnetic Resonance Elastography. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1575-0_3

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