Abstract
The purpose of this study was to prospectively compare the performance of magnetic resonance (MR) elastography using echo-planar and spin-echo imaging for staging of hepatic fibrosis. Twenty-four patients who had liver biopsy for suspicion of chronic liver disease had MR elastography performed with both spin-echo and echo-planar sequences. At histology, the fibrosis stage was assessed according to METAVIR. The data acquisition time was about 20 min using spin-echo, and only 2 min using echo-planar imaging. The hepatic signal-to-noise ratios were similar on both images (22.51 ± 5.37 for spin-echo versus 21.02 ± 4.76 for echo-planar, p = 0.33). The elasticity measurements and the fibrosis stages were strongly correlated. The Spearman correlation coefficients were r = 0.91 (p < 0.01) with spin-echo and r = 0.84 (p < 0.01) with echo-planar sequences. These correlation coefficients did not differ significantly (p = 0.17). A strong correlation was also observed between spin-echo and echo-planar elasticity (r = 0.83, p < 0.001), without systematic bias. The results of our study showed that echo-planar imaging substantially decreased the data acquisition time of MR elastography, while maintaining the image quality and diagnostic performance for staging of liver fibrosis. This suggests that echo-planar MR elastography could replace spin-echo MR elastography in clinical practice.
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References
Bravo AA, Sheth SG, Chopra S (2001) Liver biopsy. N Engl J Med 344:495–500
Cadranel JF, Rufat P, Degos F (2000) Practices of liver biopsy in France: results of a prospective nationwide survey. For the Group of Epidemiology of the French Association for the Study of the Liver (AFEF). Hepatology 32:477–481
Bedossa P, Dargere D, Paradis V (2003) Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology 38:1449–1457
Castera L, Negre I, Samii K, Buffet C (1999) Pain experienced during percutaneous liver biopsy. Hepatology 30:1529–1530
Poynard T, Ratziu V, Bedossa P (2000) Appropriateness of liver biopsy. Can J Gastroenterol 14:543–548
Regev A, Berho M, Jeffers LJ et al (2002) Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol 97:2614–2618
Rockey DC, Bissell DM (2006) Noninvasive measures of liver fibrosis. Hepatology 43:S113–S120
Huwart L, Peeters F, Sinkus R et al (2006) Liver fibrosis: non-invasive assessment with MR elastography. NMR Biomed 19:173–179
Huwart L, Sempoux C, Salameh N et al (2007) Liver fibrosis: noninvasive assessment with MR elastography versus aspartate aminotransferase to-platelet ratio index. Radiology 245:458–466
Rouviere O, Yin M, Dresner MA et al (2006) MR elastography of the liver: preliminary results. Radiology 240:440–448
Sandrin L, Fourquet B, Hasquenoph JM et al (2003) Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol 29:1705–1713
Ziol M, Handra-Luca A, Kettaneh A et al (2005) Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C. Hepatology 41:48–54
Castera L, Vergniol J, Foucher J et al (2005) Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C. Gastroenterology 128:343–350
Foucher J, Chanteloup E, Vergniol J et al (2006) Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study. Gut 55:403–408
Ganne-Carrie N, Ziol M, de Ledinghen V et al (2006) Accuracy of liver stiffness measurement for the diagnosis of cirrhosis in patients with chronic liver diseases. Hepatology 44:1511–1517
Sinkus R, Tanter M, Xydeas T, Catheline S, Bercoff J, Fink M (2005) Viscoelastic shear properties of in vivo breast lesions measured by MR elastography. Magn Reson Imaging 23:150–165
Yin M, Manduca M, Romano AJ et al (2007) 3-D local frequency estimation inversion for abdominal MR Elastography. In: Proc Intl Soc Magn Reson Med 15:960
The French METAVIR Cooperative Study Group (1994) Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. Hepatology 0:15–20
Bedossa P, Poynard T, The METAVIR Cooperative Study Group (1996) An algorithm for the grading of activity in chronic hepatitis C. Hepatology 24:289–293
Meng X-L, Rosenthal R, Rubin DB (1992) Comparing correlated correlation coefficients. Psychol Bull 111:172–175
Zou KH, Tuncali K, Silverman SG (2003) Correlation and simple linear regression. Radiology 227:617–622
Hamhaber U, Sack I, Papazoglou S, Rump J, Klatt D, Braun J (2007) Three-dimensional analysis of shear wave propagation observed by in vivo magnetic resonance elastography of the brain. Acta Biomater 3:127–137
Klatt D, Asbach P, Rump J et al (2006) In vivo determination of hepatic stiffness using steady-state free precession magnetic resonance elastography. Invest Radiol 41:841–848
Rump J, Klatt D, Braun J, Warmuth C, Sack I (2007) Fractional encoding of harmonic motions in MR elastography. Magn Reson Med 57:388–395
Yin M, Talwalkar JA, Glaser KJ et al (2007) Assessment of hepatic fibrosis with magnetic resonance elastography. Clin Gastroenterol Hepatol 5:1207–1213 e1202
Glaser KJ, Felmlee JP, Ehman RL (2006) Rapid MR elastography using selective excitations. Magn Reson Med 55:1381–1389
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This work was supported by grants FRSM 3.4578.00 and 3.4580.06 from the Fonds National de la Recherche Scientifique, Belgium.
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Huwart, L., Salameh, N., ter Beek, L. et al. MR elastography of liver fibrosis: preliminary results comparing spin-echo and echo-planar imaging. Eur Radiol 18, 2535–2541 (2008). https://doi.org/10.1007/s00330-008-1051-5
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DOI: https://doi.org/10.1007/s00330-008-1051-5