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Influence of the Maternal Use of Labetalol on the Neurogenic Mechanism for Cerebral Autoregulation Assessed by Means of NIRS

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Oxygen Transport to Tissue XXXVI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 812))

Abstract

Labetalol is a drug used in the treatment of hypertensive disorders of pregnancy (HDP). In a previous study we investigated the influence of the maternal use of labetalol on the cerebral autoregulation (CA) mechanism of neonates. In that study, we found that labetalol induces impaired CA during the first day of life, with CA returning to a normal status by the third day after birth. This effect was hypothesized to be caused by labetalol-induced vasodilation. However, no strong evidence for this claim was found. In this study we aim to find stronger evidence for the vasodilation effect caused by labetalol, by investigating its effect on the neurogenic mechanism (NM) involved in CA. The status of the NM was assessed by means of transfer function analysis between the low frequency content of the autonomic control activity (LFA), obtained by processing of the heart rate (HR), and the regional cerebral oxygen saturation (rScO2). We found that neonates from mothers treated with labetalol presented a lower LFA and an impaired NM response during the first day of life, with values returning to normal by the end of the third day. These results reflect a vasodilation effect caused by labetalol, and indicate that the impaired CA observed in the previous study is caused by vasodilation.

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Acknowledgments

Research supported by a postdoctoral mandate of the KU Leuven (BOF-KU Leuven) and: Research Council KUL: GOA MaNet, PFV/10/002 (OPTEC), IDO 08/013 Autism, several PhD/postdoc & fellow grants. Flemish Government: FWO: PhD/postdoc grants, projects: G.0427.10N (Integrated EEG-fMRI), G.0108.11 (Compressed Sensing) G.0869.12N (Tumor imaging) G.0A5513N (Deep brain stimulation); IWT: TBM070713-Accelero, TBM080658-MRI (EEG-fMRI), TBM110697-NeoGuard, PhD Grants; iMinds 2013; Flanders Care: Demonstratieproject Tele-Rehab III (2012–2014). Belgian Federal Science Policy Office: IUAP P719/(DYSCO, `Dynamical systems, control and optimization', 2012–2017); ESA AO-PGPF-01, PRODEX (CardioControl) C4000103224. EU: RECAP 209G within INTERREG IVB NWE programme, EU HIP Trial FP7-HEALTH/ 2007–2013 (n° 260777), EU MC ITN Transact 2012 # 316679 y carito linda.

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Authors and Affiliations

  1. Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing, and Data Analytics, KU Leuven, Kasteelpark Arenberg 10, 2446, Heverlee (Leuven), Vlaams-Brabant, 3001, Belgium

    Alexander Caicedo, Carolina Varon & Sabine Van Huffel

  2. iMinds Medical IT, KU Leuven, Leuven, Belgium

    Alexander Caicedo, Carolina Varon & Sabine Van Huffel

  3. Neonatal Intensive Care Unit, University Hospitals Leuven, KU Leuven, Leuven, Belgium

    Liesbeth Thewissen & Gunnar Naulaers

  4. Department of Neonatology, Wilhelmina Children’s Hospital, University Medical Center, Utrecht, The Netherlands

    Petra Lemmers & Frank Van Bel

Authors
  1. Alexander Caicedo
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  2. Carolina Varon
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  3. Liesbeth Thewissen
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  4. Gunnar Naulaers
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  5. Petra Lemmers
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  6. Frank Van Bel
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  7. Sabine Van Huffel
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Corresponding author

Correspondence to Alexander Caicedo .

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Editors and Affiliations

  1. EPR Center for the Study of Viable Systems, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA

    Harold M. Swartz

  2. Microvascular Measurements, St. Lorenzen, Italy

    David K. Harrison

  3. Synthesizer Inc., Ellicott City, MD, USA

    Duane F. Bruley

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Caicedo, A. et al. (2014). Influence of the Maternal Use of Labetalol on the Neurogenic Mechanism for Cerebral Autoregulation Assessed by Means of NIRS. In: Swartz, H.M., Harrison, D.K., Bruley, D.F. (eds) Oxygen Transport to Tissue XXXVI. Advances in Experimental Medicine and Biology, vol 812. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0620-8_23

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