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Obesity and Metabolic Syndrome: Etiopathogenic Analysis

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Integrative Weight Management

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Abstract

Obesity is a global pandemic and has become a serious health problem worldwide by producing considerable morbidity and mortality. Thus it is imperative for the scientific community to become familiar with the key etiological factors that are ultimately responsible for the development of obesity. The objective of this chapter is to review the important events involved in the pathophysiology of obesity leading to the dysregulation of energy balance, appetite, and metabolism.

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References

  1. Aguilar Cordero MJ, Gonzalez Jimenez E, Garcia Garcia CJ, Garcia Lopez PA, Alvarez Ferre J, Padilla Lopez CA, et al. Obesity in a school children population from Granada: assessment of the efficacy of an educational intervention. Nutr Hosp. 2011;26(3):636–41.

    PubMed  Google Scholar 

  2. Aguilar Cordero MJ, Gonzalez Jimenez E, Garcia Garcia CJ, Garcia Lopez P, Alvarez Ferre J, Padilla Lopez CA, et al. Comparative study of the effectiveness of body mass index and the body-fat percentage as methods for the diagnosis of overweight and obesity in children. Nutr Hosp. 2012;27(1):185–91.

    PubMed  Google Scholar 

  3. Plachta-Danielzik S, Landsberg B, Seiberl J, Gehrke MI, Gose M, Kehden B, et al. Longitudinal data of the Kiel Obesity Prevention Study (KOPS). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012;55 (6–7):885–91.

    Article  CAS  PubMed  Google Scholar 

  4. Juonala M, Magnussen CG, Berenson GS, Venn A, Burns TL, Sabin MA, et al. Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med. 2011;365(20):1876–85.

    Article  CAS  PubMed  Google Scholar 

  5. Harris RB. Is leptin the parabiotic “satiety” factor? Past and present interpretations. Appetite. 2013;61(1):111–8.

    Article  PubMed Central  PubMed  Google Scholar 

  6. Martindale RG, DeLegge M, McClave S, Monroe C, Smith V, Kiraly L. Nutrition delivery for obese ICU patients: delivery issues, lack of guidelines, and missed opportunities. J Parenter Enteral Nutr. 2011;35(5 Suppl):80S–7.

    Article  CAS  Google Scholar 

  7. McClave SA, Kushner R, Van Way 3rd CW, Cave M, DeLegge M, Dibaise J, et al. Nutrition therapy of the severely obese, critically ill patient: summation of conclusions and recommendations. J Parenter Enteral Nutr. 2011;35 (5 Suppl):88S–96.

    Article  Google Scholar 

  8. Tounian P. Programming towards childhood obesity. Ann Nutr Metab. 2011;58 Suppl 2:30–41.

    Article  CAS  PubMed  Google Scholar 

  9. Serene TE, Shamarina S, Mohd NM. Familial and socio-environmental predictors of overweight and obesity among primary school children in Selangor and Kuala Lumpur. Malays J Nutr. 2011;17(2):151–62.

    PubMed  Google Scholar 

  10. Murrin CM, Kelly GE, Tremblay RE, Kelleher CC. Body mass index and height over three generations: evidence from the lifeways cross-generational cohort study. BMC Public Health. 2012;12:81.

    Article  PubMed Central  PubMed  Google Scholar 

  11. Zhang L, Avila L, Leyraud L, Grassi S, Grassi S, Raquel T, Bonfanti T, Ferruzzi E. Accuracy of parental and child’s reports of changes in symptoms of childhood asthma. Indian Pediatr. 2006;43(1):48–54.

    PubMed  Google Scholar 

  12. Doo M, Kim Y. Association between ESR1 rs1884051 polymorphism and dietary total energy and plant protein intake on obesity in Korean men. Nutr Res Pract. 2011;5(6):527–32.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. Perusse L, Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, et al. The human obesity gene map: the 2004 update. Obes Res. 2005;13(3):381–490.

    Article  CAS  PubMed  Google Scholar 

  14. Baturin AK, Pogozheva AV, Sorokina E, Makurina ON, Tutel’ian VA. The study of polymorphism rs9939609 FTO gene in patients with overweight and obesity. Vopr Pitan. 2011;80(3):13–7.

    CAS  PubMed  Google Scholar 

  15. Peng S, Zhu Y, Xu F, Ren X, Li X, Lai M. FTO gene polymorphisms and obesity risk: a meta-analysis. BMC Med. 2011;9:71.

    Article  PubMed Central  PubMed  Google Scholar 

  16. McTaggart JS, Lee S, Iberl M, Church C, Cox RD, Ashcroft FM. FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting. PLoS One. 2011;6(11):e27968.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  17. Liu G, Zhu H, Dong Y, Podolsky RH, Treiber FA, Snieder H. Influence of common variants in FTO and near INSIG2 and MC4R on growth curves for adiposity in African- and European-American youth. Eur J Epidemiol. 2011;26(6):463–73.

    Article  PubMed Central  PubMed  Google Scholar 

  18. Wardle J, Carnell S, Haworth CM, Farooqi IS, O’Rahilly S, Plomin R. Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab. 2008;93(9):3640–3.

    Article  CAS  PubMed  Google Scholar 

  19. Gonzalez JE. Genes and obesity: a cause and effect relationship. Endocrinologia y nutricion : organo de la Sociedad Espanola de. Endocrinol Nutr. 2011;58(9):492–6.

    Article  Google Scholar 

  20. Nativio DG. The genetics, diagnosis, and management of Prader-Willi syndrome. J Pediatr Health Care. 2002; 16(6):298–303.

    Article  PubMed  Google Scholar 

  21. Braghetto I, Rodriguez A, Debandi A, Brunet L, Papapietro K, Pineda P, et al. Prader-Willi Syndrome (PWS) associated to morbid obesity: surgical treatment. Rev Med Chil. 2003;131(4):427–31.

    Article  PubMed  Google Scholar 

  22. Girard D, Petrovsky N. Alstrom syndrome: insights into the pathogenesis of metabolic disorders. Nat Rev Endocrinol. 2011;7(2):77–88.

    Article  CAS  PubMed  Google Scholar 

  23. Deeble VJ, Roberts E, Jackson A, Lench N, Karbani G, Woods CG. The continuing failure to recognise Alstrom syndrome and further evidence of genetic homogeneity. J Med Genet. 2000;37(3):219.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  24. Marshall JD, Ludman MD, Shea SE, Salisbury SR, Willi SM, LaRoche RG, et al. Genealogy, natural history, and phenotype of Alstrom syndrome in a large Acadian kindred and three additional families. Am J Med Genet. 1997;73(2):150–61.

    Article  CAS  PubMed  Google Scholar 

  25. Tehrani AB, Nezami BG, Gewirtz A, Srinivasan S. Obesity and its associated disease: a role for microbiota? Neurogastroenterol Motil. 2012;24(4):305–11.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  26. Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes. 2008;57(6):1470–81.

    Article  CAS  PubMed  Google Scholar 

  27. Sato M, Uzu K, Yoshida T, Hamad EM, Kawakami H, Matsuyama H, et al. Effects of milk fermented by Lactobacillus gasseri SBT2055 on adipocyte size in rats. Br J Nutr. 2008;99(5):1013–7.

    Article  CAS  PubMed  Google Scholar 

  28. Ma X, Hua J, Li Z. Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells. J Hepatol. 2008;49(5):821–30.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  29. Skinner JD, Carruth BR, Moran 3rd J, Houck K, Coletta F. Fruit juice intake is not related to children’s growth. Pediatrics. 1999;103(1):58–64.

    Article  CAS  PubMed  Google Scholar 

  30. Cavadini C, Siega-Riz AM, Popkin BM. US adolescent food intake trends from 1965 to 1996. West J Med. 2000; 173(6):378–83.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  31. González JE. Evaluación de la eficacia de una intervención educativa sobre nutrición y actividad física en niños y adolescentes escolares con sobrepeso y obesidad de Granada y provincia. Tesis Doctoral. Granada: Universidad de Granada; 2010.

    Google Scholar 

  32. Viner RM, Segal TY, Lichtarowicz-Krynska E, Hindmarsh P. Prevalence of the insulin resistance syndrome in obesity. Arch Dis Child. 2005;90(1):10–4.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  33. Welsh JA, Cogswell ME, Rogers S, Rockett H, Mei Z, Grummer-Strawn LM. Overweight among low-income preschool children associated with the consumption of sweet drinks: Missouri, 1999–2002. Pediatrics. 2005; 115(2):e223–9.

    Article  PubMed  Google Scholar 

  34. Martinez AB, Caballero-Plasencia A, Mariscal-Arcas M, Velasco J, Rivas A, Olea-Serrano F. Study of nutritional menus offered at noon school in Granada. Nutr Hosp. 2010;25(3):394–9.

    CAS  PubMed  Google Scholar 

  35. Salmon J, Timperio A, Telford A, Carver A, Crawford D. Association of family environment with children’s television viewing and with low level of physical activity. Obes Res. 2005;13(11):1939–51.

    Article  PubMed  Google Scholar 

  36. Serra-Majem L, Aranceta Bartrina J, Perez-Rodrigo C, Ribas-Barba L, Delgado-Rubio A. Prevalence and determinants of obesity in Spanish children and young people. Br J Nutr. 2006;96 Suppl 1:S67–72.

    Article  CAS  PubMed  Google Scholar 

  37. Stefanick ML. Physical activity for preventing and treating obesity-related dyslipoproteinemias. Med Sci Sports Exerc. 1999;31(11 Suppl):S609–18.

    Article  CAS  PubMed  Google Scholar 

  38. Badman MK, Flier JS. The gut and energy balance: visceral allies in the obesity wars. Science. 2005;307(5717): 1909–14.

    Article  CAS  PubMed  Google Scholar 

  39. Lowell BB, Spiegelman BM. Towards a molecular understanding of adaptive thermogenesis. Nature. 2000;404(6778): 652–60.

    CAS  PubMed  Google Scholar 

  40. Ravussin E. Physiology. A NEAT way to control weight? Science. 2005;307(5709):530–1.

    Article  CAS  PubMed  Google Scholar 

  41. Hill JO, Wyatt HR, Reed GW, Peters JC. Obesity and the environment: where do we go from here? Science. 2003;299(5608):853–5.

    Article  CAS  PubMed  Google Scholar 

  42. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009;360(15):1509–17.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  43. Lopez-Jaramillo P, Garcia RG, Lopez M. Preventing pregnancy-induced hypertension: are there regional differences for this global problem? J Hypertens. 2005;23(6):1121–9.

    Article  CAS  PubMed  Google Scholar 

  44. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998;395(6704):763–70.

    Article  CAS  PubMed  Google Scholar 

  45. Ahima RS, Flier JS. Leptin. Annu Rev Physiol. 2000;62:413–37.

    Article  CAS  PubMed  Google Scholar 

  46. Coll AP, Farooqi IS, O’Rahilly S. The hormonal control of food intake. Cell. 2007;129(2):251–62.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  47. Robertson SA, Leinninger GM, Myers Jr MG. Molecular and neural mediators of leptin action. Physiol Behav. 2008;94(5):637–42.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  48. Hegyi K, Fulop K, Kovacs K, Toth S, Falus A. Leptin-induced signal transduction pathways. Cell Biol Int. 2004; 28(3):159–69.

    Article  CAS  PubMed  Google Scholar 

  49. Breton C. The hypothalamus-adipose axis is a key target of developmental programming by maternal nutritional manipulation. J Endocrinol. 2013;216(2):R19–31.

    Article  CAS  PubMed  Google Scholar 

  50. Haskell-Luevano C, Cone RD, Monck EK, Wan YP. Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis: identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinants. Biochemistry. 2001;40(20):6164–79.

    Article  CAS  PubMed  Google Scholar 

  51. Cone RD. Anatomy and regulation of the central melanocortin system. Nat Neurosci. 2005;8(5):571–8.

    Article  CAS  PubMed  Google Scholar 

  52. Nijenhuis WA, Oosterom J, Adan RA. AgRP(83–132) acts as an inverse agonist on the human-melanocortin-4 receptor. Mol Endocrinol. 2001;15(1):164–71.

    CAS  PubMed  Google Scholar 

  53. Saper CB, Chou TC, Elmquist JK. The need to feed: homeostatic and hedonic control of eating. Neuron. 2002;36(2): 199–211.

    Article  CAS  PubMed  Google Scholar 

  54. Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, et al. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 2006;51(2):239–49.

    Article  CAS  PubMed  Google Scholar 

  55. Yadav VK, Oury F, Tanaka KF, Thomas T, Wang Y, Cremers S, et al. Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implications. J Exp Med. 2011;208(1):41–52.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  56. Bloom S. Hormonal regulation of appetite. Obes Rev. 2007;8 Suppl 1:63–5.

    Article  CAS  PubMed  Google Scholar 

  57. Roth CL, Enriori PJ, Gebhardt U, Hinney A, Muller HL, Hebebrand J, et al. Changes of peripheral alpha-melanocyte-stimulating hormone in childhood obesity. Metabolism. 2010;59(2):186–94.

    Article  CAS  PubMed  Google Scholar 

  58. Cummings DE, Overduin J. Gastrointestinal regulation of food intake. J Clin Invest. 2007;117(1):13–23.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  59. Magni P, Vettor R, Pagano C, Calcagno A, Martini L, Motta M. Control of the expression of human neuropeptide Y by leptin: in vitro studies. Peptides. 2001;22(3):415–20.

    Article  CAS  PubMed  Google Scholar 

  60. Woods SC, D’Alessio DA. Central control of body weight and appetite. J Clin Endocrinol Metab. 2008;93(11 Suppl 1): S37–50.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  61. Hameed S, Dhillo WS, Bloom SR. Gut hormones and appetite control. Oral Dis. 2009;15(1):18–26.

    Article  CAS  PubMed  Google Scholar 

  62. Tschop M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes. 2001;50(4):707–9.

    Article  CAS  PubMed  Google Scholar 

  63. Batterham RL, Le Roux CW, Cohen MA, Park AJ, Ellis SM, Patterson M, et al. Pancreatic polypeptide reduces appetite and food intake in humans. J Clin Endocrinol Metab. 2003;88(8):3989–92.

    Article  CAS  PubMed  Google Scholar 

  64. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402(6762):656–60.

    Article  CAS  PubMed  Google Scholar 

  65. Pusztai P, Sarman B, Ruzicska E, Toke J, Racz K, Somogyi A, et al. Ghrelin: a new peptide regulating the neurohormonal system, energy homeostasis and glucose metabolism. Diabetes Metab Res Rev. 2008;24(5):343–52.

    Article  CAS  PubMed  Google Scholar 

  66. Huda MS, Wilding JP, Pinkney JH. Gut peptides and the regulation of appetite. Obes Rev. 2006;7(2):163–82.

    Article  CAS  PubMed  Google Scholar 

  67. Muscelli E, Mari A, Casolaro A, Camastra S, Seghieri G, Gastaldelli A, et al. Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients. Diabetes. 2008;57(5): 1340–8.

    Article  CAS  PubMed  Google Scholar 

  68. Opinto G, Natalicchio A, Marchetti P. Physiology of incretins and loss of incretin effect in type 2 diabetes and obesity. Arch Physiol Biochem. 2013;119(4):170–8.

    Article  CAS  PubMed  Google Scholar 

  69. Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007;132(6):2131–57.

    Article  CAS  PubMed  Google Scholar 

  70. Madsbad S, Krarup T, Deacon CF, Holst JJ. Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trials. Curr Opin Clin Nutr Metab Care. 2008; 11(4):491–9.

    Article  CAS  PubMed  Google Scholar 

  71. Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, et al. Functional brown adipose tissue in healthy adults. N Engl J Med. 2009;360(15):1518–25.

    Article  CAS  PubMed  Google Scholar 

  72. Astrup A, Carraro R, Finer N, Harper A, Kunesova M, Lean ME, et al. Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide. Int J Obes (Lond). 2012;36(6):843–54.

    Article  CAS  Google Scholar 

  73. Essah PA, Levy JR, Sistrun SN, Kelly SM, Nestler JE. Effect of macronutrient composition on postprandial peptide YY levels. J Clin Endocrinol Metab. 2007;92(10):4052–5.

    Article  CAS  PubMed  Google Scholar 

  74. Arsenijevic D, Gallmann E, Moses W, Lutz T, Erlanson-Albertsson C, Langhans W. Enterostatin decreases postprandial pancreatic UCP2 mRNA levels and increases plasma insulin and amylin. Am J Physiol Endocrinol Metab. 2005;289(1):E40–5.

    Article  CAS  PubMed  Google Scholar 

  75. Karra E, Chandarana K, Batterham RL. The role of peptide YY in appetite regulation and obesity. J Physiol. 2009;587(Pt 1):19–25.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  76. Teubner BJ, Bartness TJ. PYY into the arcuate nucleus inhibits food deprivation-induced increases in food hoarding and intake. Peptides. 2013;47C:20–8.

    Article  Google Scholar 

  77. Vermeulen A, Goemaere S, Kaufman JM. Testosterone, body composition and aging. J Endocrinol Invest. 1999; 22(5 Suppl):110–6.

    CAS  PubMed  Google Scholar 

  78. Couillard C, Gagnon J, Bergeron J, Leon AS, Rao DC, Skinner JS, et al. Contribution of body fatness and adipose tissue distribution to the age variation in plasma steroid hormone concentrations in men: the HERITAGE Family Study. J Clin Endocrinol Metab. 2000;85(3):1026–31.

    CAS  PubMed  Google Scholar 

  79. Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37(12):1595–607.

    Article  CAS  PubMed  Google Scholar 

  80. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002;287(3):356–9.

    Article  PubMed  Google Scholar 

  81. Meigs JB, Muller DC, Nathan DM, Blake DR, Andres R. Baltimore Longitudinal Study of A. The natural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore Longitudinal Study of Aging. Diabetes. 2003;52(6):1475–84.

    Article  CAS  PubMed  Google Scholar 

  82. Ridker PM, Buring JE, Cook NR, Rifai N. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation. 2003;107(3): 391–7.

    Article  PubMed  Google Scholar 

  83. Sattar N, Gaw A, Scherbakova O, Ford I, O’Reilly DS, Haffner SM, et al. Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study. Circulation. 2003;108(4):414–9.

    Article  CAS  PubMed  Google Scholar 

  84. Siani A, Cappuccio FP, Barba G, Trevisan M, Farinaro E, Lacone R, et al. The relationship of waist circumference to blood pressure: the Olivetti Heart Study. Am J Hypertens. 2002;15(9):780–6.

    Article  PubMed  Google Scholar 

  85. Alvarez Leon EE, Ribas Barba L, Serra ML. Prevalence of the metabolic syndrome in the population of Canary Islands, Spain. Med Clin. 2003;120(5):172–4.

    Article  Google Scholar 

  86. Mills GW, Avery PJ, McCarthy MI, Hattersley AT, Levy JC, Hitman GA, et al. Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes. Diabetologia. 2004;47(4):732–8.

    Article  CAS  PubMed  Google Scholar 

  87. Miettinen TA, Gylling H, Raitakari OT, Hallikainen M, Viikari J. Adolescent cholesterol metabolism predicts coronary risk factors at middle age: the Cardiovascular Risk in Young Finns Study. Transl Res. 2008;151(5):260–6.

    Article  CAS  PubMed  Google Scholar 

  88. Srinivasan SR, Myers L, Berenson GS. Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood: the Bogalusa Heart Study. Diabetes. 2002;51(1):204–9.

    Article  CAS  PubMed  Google Scholar 

  89. Cruz ML, Weigensberg MJ, Huang TT, Ball G, Shaibi GQ, Goran MI. The metabolic syndrome in overweight Hispanic youth and the role of insulin sensitivity. J Clin Endocrinol Metab. 2004;89(1):108–13.

    Article  CAS  PubMed  Google Scholar 

  90. Zimmet P, Magliano D, Matsuzawa Y, Alberti G, Shaw J. The metabolic syndrome: a global public health problem and a new definition. J Atheroscler Thromb. 2005;12(6):295–300.

    Article  CAS  PubMed  Google Scholar 

  91. IDF. International Diabetes Federation. The IDF consensus worldwide definition of the metabolic syndrome. Diabetes atlas 2003; Disponible en: http://www.idf.org/webdata/docs/IDF_Metasyndrome_definition.pdf 2003.

  92. Burrows R. Prevention and treatment of obesity since childhood: strategy to decrease the non transmissible chronic diseases in adult. Rev Med Chil. 2000;128(1):105–10.

    Article  CAS  PubMed  Google Scholar 

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González-Jiménez, E., Mullin, G.E. (2014). Obesity and Metabolic Syndrome: Etiopathogenic Analysis. In: Mullin, G., Cheskin, L., Matarese, L. (eds) Integrative Weight Management. Nutrition and Health. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0548-5_5

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