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Application of “Omics” Technologies to In Vitro Toxicology

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In Vitro Toxicology Systems

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

“Omics” technologies have facilitated significant advances in the understanding of toxicity mechanisms in complex biological systems. In this chapter we discuss the most important “omics” technologies and how they are currently applied in the field of in vitro toxicology. For each technology, advantages, limitations, and developmental needs are addressed. In addition, we provide some future prospects on the role of “omics” technologies in the emerging new paradigm of mechanistic toxicity studies. It becomes clear that technological developments have enhanced the application of “omics” technologies in toxicology and simplified the interpretation of the generated information; nevertheless, significant challenges remain to incorporate “omics” technologies and “omics” data in the regulatory decision making process.

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Authors and Affiliations

  1. Doerenkamp-Zbinden Department of in vitro Toxicology and Biomedicine, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany

    Nina V. Balmer, Marcel Leist & Tanja Waldmann

  2. Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, TX, USA

    Kinga Vojnits

  3. Center for Stem Cell Research and Regenerative Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA

    Kinga Vojnits

  4. Department of Environmental Health Science, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 21205, USA

    Tyna Dao & Liang Zhao

  5. Department of Environmental Health Science, Center for Alternative to Animal Testing (CAAT), Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 21205, USA

    Helena T. Hogberg

  6. SeCAM Services and Consultation on Alternative Methods, via Lugano 13, 6982, Agno, Switzerland

    Erwin van Vliet

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  1. Nina V. Balmer
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  2. Tyna Dao
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  3. Marcel Leist
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  4. Kinga Vojnits
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  5. Tanja Waldmann
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  6. Liang Zhao
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  7. Helena T. Hogberg
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  8. Erwin van Vliet
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Correspondence to Erwin van Vliet .

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Editors and Affiliations

  1. European Commission Joint Research Centre, Ispra, Varese, Italy

    Anna Bal-Price

  2. Innsbruck Medical University, Innsbruck, Austria

    Paul Jennings

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Balmer, N.V. et al. (2014). Application of “Omics” Technologies to In Vitro Toxicology. In: Bal-Price, A., Jennings, P. (eds) In Vitro Toxicology Systems. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0521-8_18

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  • DOI: https://doi.org/10.1007/978-1-4939-0521-8_18

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