Studies on Psychiatric Disorders

  • Anna Dietrich-Muszalska
  • Ved Chauhan
  • Sylvain Grignon

Table of contents

  1. Front Matter
    Pages i-xx
  2. Grzegorz Bartosz, Izabela Sadowska-Bartosz
    Pages 1-39
  3. Clinical Aspects

    1. Front Matter
      Pages 41-41
    2. Anna Dietrich-Muszalska
      Pages 43-72
    3. Gustavo Scola, Ana C. Andreazza
      Pages 73-87
    4. Marina Čeprnja, Vladimira Vuletić
      Pages 121-129
    5. Jolanta Rabe-Jabłońska, Anna Dietrich-Muszalska
      Pages 131-141
    6. Dominika Książek-Winiarek, Andrzej Głąbiński
      Pages 151-167
  4. Pathophysiological Aspects

    1. Front Matter
      Pages 169-169
    2. Jessica Deslauriers, Philippe Sarret, Sylvain Grignon
      Pages 197-210
    3. Sylvain Grignon, Jessica Deslauriers
      Pages 211-230
    4. Daniel A. Rossignol, Richard E. Frye
      Pages 231-244
    5. Benjamín Pineda, Victoria Campos-Peña, Rafael Lugo-Huitrón, Camilo Ríos, Verónica Pérez-de la Cruz
      Pages 245-268
    6. Anna Dietrich-Muszalska, Grzegorz Bartosz, Izabela Sadowska-Bartosz
      Pages 299-326
    7. Abha Chauhan, Feng Gu, Ved Chauhan
      Pages 355-372

About this book

Introduction

This authoritative volume reviews clinical, pathophysiological and therapeutic aspects of oxidative and nitrosative stress in different psychiatric disorders such as schizophrenia, bipolar disorder, autism, and attention deficit hyperactivity disorder (ADHD). Twenty-nine comprehensive chapters are divided into three distinct sections: clinical aspects, pathophysiological aspects, and therapeutic aspects. Together, these chapters present the environmental, genetic and neurodevelopmental factors in the generation of oxidative stress in psychiatric disorders, with particular emphasis on the biochemical changes associated with oxidative stress in dopaminergic and glutamate neurotransmission as well as mitochondrial dysfunction in the brain and peripheral cells. Through an investigation of glutamic acid decarboxylase (GAD) abnormalities in schizophrenia, the book provides a coherent framework to account for the impact of oxidative stress on pathological phenomena ranging from cellular to cognitive and clinical aspects. It describes biomarkers of oxidative damage, the role of oxidative stress in numerous abnormalities of biochemical pathways in the pathophysiology of schizophrenia, the development of new investigative techniques, specially neuroimaging, and studies of apoptotic pathways that seem to prove neurodegenerative and neurodevelopmental theories.

Written by leading researchers in their fields, Studies on Psychiatric Disorders explores therapeutic approaches with aspects of various antioxidants, cryostimulation, and hyperbaric oxygen treatment in oxidative stress in neuropsychiatric diseases. The volume also discusses the role of antipsychotics in the treatment of schizophrenia on nitric oxide generation and biomarkers of oxidative stress together with the clinical symptomatology. Overall, it proposes that novel therapeutic strategies such as supplementation with antioxidants—in particular polyphenols, ω-3 fatty acids or combination of both—could be effective for long-term treatment of some neuropsychiatric disorders.

Keywords

Chauhan Dietrich-Muszalska Grignon Psychiatric Disorder Studies

Editors and affiliations

  • Anna Dietrich-Muszalska
    • 1
  • Ved Chauhan
    • 2
  • Sylvain Grignon
    • 3
  1. 1.Department of Biological Psychiatry of the Chair of Experimental and Clinical PhysiologyMedical University of LodzLodzPoland
  2. 2.Department of NeurochemistryNew York State Institute for Basic ResearchStaten IslandUSA
  3. 3.Departments of Psychiatry and Physiology & BiophysicsUniversity of SherbrookeSherbrooke, QuebecCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-0440-2
  • Copyright Information Springer Science+Business Media New York 2015
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4939-0439-6
  • Online ISBN 978-1-4939-0440-2
  • Series Print ISSN 2197-7224
  • Series Online ISSN 2197-7232
  • About this book