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Hyperbaric Oxygen Treatment in Autism Spectrum Disorders

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Studies on Psychiatric Disorders

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Abstract

Hyperbaric oxygen treatment (HBOT) has been reported to improve cerebral hypoperfusion, inflammation, and mitochondrial dysfunction, all of which have been observed in some individuals with autism spectrum disorders (ASD). In several studies, HBOT improved cerebral hypoperfusion, decreased a marker of inflammation, and did not worsen oxidative stress markers at pressures commonly used in children with ASD. Most studies of HBOT in children with ASD reported improvements in several behavioral domains, although many of these studies were not controlled. The two studies employing a control group appear to have conflicting results. However, this may have been due to different sample sizes and frequencies of HBOT sessions, with the larger study reporting improvements in several domains using a greater intensity of treatments. All studies reported that HBOT had minimal adverse events. Additional studies of HBOT in individuals with ASD are warranted to determine optimal treatment protocols.

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Abbreviations

ASD:

Autism spectrum disorder

ATEC:

Autism Treatment Evaluation Checklist

ATM:

Atmosphere

ATP:

Adenosine triphosphate

CARS:

Childhood Autism Rating Scale

CSF:

Cerebrospinal fluid

fMRI:

Functional magnetic resonance imaging

HBOT:

Hyperbaric oxygen treatment

IHA:

International Hyperbarics Association

PET:

Positron emission tomography

ROS:

Reactive oxygen species

SOD:

Superoxide dismutase

SPECT:

Single-photon emission computed tomography

SRS:

Social Responsiveness Scale

TBI:

Traumatic brain injury

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Competing Interests

The author treats individuals with HBOT in his clinical practice and derives revenue from this. He has previously received research funding from the International Hyperbarics Association (IHA) for two studies of hyperbaric treatment in children with autism (Rossignol et al. 2007, 2009) and is a medical advisor (unpaid) for IHA.

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Authors and Affiliations

  1. Rossignol Medical Center, 3800 West Eau Gallie Blvd., Melbourne, 32934, FL, USA

    Daniel A. Rossignol M.D., FAAFP

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  1. Daniel A. Rossignol M.D., FAAFP
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Correspondence to Daniel A. Rossignol M.D., FAAFP .

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Editors and Affiliations

  1. Department of Biological Psychiatry of the Chair of Experimental and Clinical Physiology, Medical University of Lodz, Lodz, Poland

    Anna Dietrich-Muszalska

  2. Department of Neurochemistry, New York State Institute for Basic Research, Staten Island, New York, USA

    Ved Chauhan

  3. Departments of Psychiatry and Physiology & Biophysics, University of Sherbrooke, Sherbrooke, Quebec, Canada

    Sylvain Grignon

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Rossignol, D.A. (2015). Hyperbaric Oxygen Treatment in Autism Spectrum Disorders. In: Dietrich-Muszalska, A., Chauhan, V., Grignon, S. (eds) Studies on Psychiatric Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0440-2_27

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