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Cellular Mechanism Underlying the Misfunction of Cardiac Ionic Channels in Diabetes

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Diabetic Cardiomyopathy

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 9))

Abstract

The alterations observed in the ECG of diabetic patients correspond to alterations in the repolarizing currents of the cardiac action potential. Diabetes affects the amplitude and kinetics of most of the potassium currents by modifying the biophysical behavior and even the expression levels of the potassium channel-forming proteins. We review here the effects of diabetes mellitus on individual currents, as well as the intracellular mechanisms that mediate them. Then, we discuss how diabetes modifies the regulation of calcium and potassium channels, with particular emphasis on the transient outward potassium current. Impaired sympathetic activity, loss of insulin-mediated trophic effect, and impaired metabolic status have major effects on the normal functioning of potassium channels in the diabetic heart.

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Acknowledgments

 This work has been supported by Universidad del País Vasco UPV/EHU grants (PPM12/12) to O. Casis and (EHUA12/12) to M. Gallego.

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Authors and Affiliations

  1. Lascaray Research Center, University of the Basque Country (UPV/EHU), Av. Miguel de Unamuno 3, 01006, Vitoria, Spain

    Mónica Gallego & Oscar Casis

  2. Departamento de Fisiología, Facultad de Farmacia, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006, Vitoria, Spain

    Mónica Gallego & Oscar Casis

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  1. Mónica Gallego
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  2. Oscar Casis
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Correspondence to Oscar Casis .

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Editors and Affiliations

  1. Department of Biophysics, University of Ankara, Ankara, Ankara, Turkey

    Belma Turan

  2. St. Boniface Hosp. Research, Univ. of Ma Institute of Cardiovascular Sciences, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla

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Gallego, M., Casis, O. (2014). Cellular Mechanism Underlying the Misfunction of Cardiac Ionic Channels in Diabetes. In: Turan, B., Dhalla, N. (eds) Diabetic Cardiomyopathy. Advances in Biochemistry in Health and Disease, vol 9. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9317-4_11

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