Abstract
The early 1900s marked the beginning of a new field in imaging, neuroradiology. Skull radiographs became available to the medical community in the first decade of the twentieth century. Ventriculography and pneumoencephalography soon followed 2 decades later. In the ensuing years, intra-arterial catheter-based vascular imaging heralded carotid angiography. Over the ensuing 40 years, many technical advances were made with angiographic imaging; however, patients did not tolerate these well-tolerated semi-invasive procedures and suffered significant morbidity.
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Pearce MS, Salotti JA, Little MP, McHugh K, Lee C, Kim KP, Howe NL, Ronckers CM, Rajaraman P, Sir Craft AW, Parker L, Berrington de González A. Radiation exposure from CT scans in childhood and subsequent risk of leukeamia and brain tumours: a retrospective cohort study. Lancet. 2012;380(9840):499–505.
Bille BS. Migraine in school children. A study of the incidence and short-term prognosis, and a clinical, psychological and electroencephalographic comparison between children with migraine and matched controls. Acta Paediatr. 1962;51 Suppl 136:1–151.
Sillanpaa M. Headache in children. In: Olessen J, editor. Headache classification and epidemiology. New York, NY: Raven; 1994. p. 273–81.
Schwedt TJ, Guo Y, Rothner AD. “Benign” imaging abnormalities in children and adolescents with headache. Headache. 2006;46(3):387–98.
Sempere AP, Porta-Etessam J, Medrano V, et al. Neuroimaging in the evaluation of patients with non-acute headache. Cephalalgia. 2005;25(1):30–5.
The Childhood Brain Tumor Consortium. The epidemiology of headache among children with brain tumor. Headache in children with brain tumors. J Neurooncol. 1991;10(1):31–46.
Landtblom AM, Fridriksson S, Boivie J, Hillman J, Johansson G, Johansson I. Sudden onset headache: a prospective study of features, incidence and causes. Cephalalgia. 2002;22(5):354–60.
Barlow CF. Headaches and migraine in childhood. Clinics in developmental medicine. No. 91. Philadelphia, PA: JB Lippincott; 1984:204–19.
Medina LS, Pinter JD, Zurakowski D, Davis RG, Kuban K, Barnes PD. Children with headache: clinical predictors of surgical space-occupying lesions and the role of neuroimaging. Radiology. 1997;202(3):819–24.
Weingarten K, Zimmerman RD, Becker RD, Heier LA, Haimes AB, Deck MD. Subdural and epidural empyemas: MR imaging. AJR Am J Roentgenol. 1989;152(3):615–21.
Reinus WR, Wippold FJ, Erickson K. Practical selection criteria for unenhanced cranial CT in patients with acute headache. Emerg Radiol. 1994;1:81–4.
Reinus WR, Zwemer Jr FL. Clinical prediction of emergent cranial CT results. Ann Emerg Med. 1994;23:1271–8.
Reinus WR, Zwemer Jr FL, Wippold FJ, Erickson KK. Emergency imaging of patients with resolved neurologic deficits: value of immediate cranial CT. AJR Am J Roentgenol. 1994;163:667–70.
Aygun D, Bildik F. Clinical warning criteria in evaluation by computed tomography the secondary neurological headaches in adults. Eur J Neurol. 2003;10:437–42.
Sobri M, Lamont AC, Alias NA, Win MN. Red flags in patients presenting with headache: clinical indications for neuroimaging. Br J Radiol. 2003;76:532–5.
Ramier-Lassepas M, Espinosa C, Cicero JJ, Johnston KL, Clipolle RJ, Barber DL. Predictors of intracranial pathologic findings in patients who see emergency care because of headaches. Arch Neurol. 1997;54:1506–9.
Becker L, Iverson DC, Reed FM, Calonge N, Miller RS, Freeman WL. Patients with a new headache in primary care: a report from ASPN. J Fam Pract. 1988;27:41–7.
Becker LA, Green LA, Beaufait D, Kirk J, Froom J, Freeman WL. Use of CT scans for the investigation of headache: a report from ASPN, part 1. J Fam Pract. 1993;37:129–34.
Morey SS. Headache Consortium releases guidelines for use of CT or MRI in migraine work-up. Am Fam Physician. 2000;62:1699–701.
Mettler Jr FA. Essentials of radiology. 2nd ed. Philadelphia, PA: Saunders; 2005.
Marx JA, Hockberger RS, Walls JM. Rosen’s emergency medicine: concepts and clinical practice. 5th ed. St. Louis, MO: Mosby; 2002.
So EL. Classifications and epidemiologic considerations of epileptic seizures and epilepsy. Neuroimaging Clin N Am. 1995;5(4):513–26.
Wieshmann UC. Clinical application of neuroimaging in epilepsy. J Neurol Neurosurg Psychiatry. 2003;74(4):466–70.
Adams C, Hwang PA, Gilday DL, Armstrong DC, Becker LE, Hoffman HJ. Comparison of SPECT, EEG, CT, MRI, and pathology in partial epilepsy. Pediatr Neurol. 1992;8(2):97–103.
SPECT and PET in epilepsy. Lancet 1989;1(8630):135–7.
Bergen D, Bleck T, Ramsey R, et al. Magnetic resonance imaging as a sensitive and specific predictor of neoplasms removed for intractable epilepsy. Epilepsia. 1989;30(3):318–21.
Brooks BS, King DW, el Gammal T, et al. MR imaging in patients with intractable complex partial epileptic seizures. AJNR Am J Neuroradiol. 1990;11(1):93–9.
Heinz ER, Heinz TR, Radtke R, et al. Efficacy of MR vs CT in epilepsy. AJR Am J Roentgenol. 1989;152(2):347–52.
Maxwell RE, Gates JR, McGeachie R. Magnetic resonance imaging in the assessment and surgical management of epilepsy and functional neurological disorders. Appl Neurophysiol. 1987;50(1–6):369–73.
Toh KH. Clinical applications of magnetic resonance imaging in the central nervous system. Ann Acad Med Singapore. 1993;22(5):785–93.
Cascino GD, Jack Jr CR, Parisi JE, et al. MRI in the presurgical evaluation of patients with frontal lobe epilepsy and children with temporal lobe epilepsy: pathologic correlation and prognostic importance. Epilepsy Res. 1992;11(1):51–9.
Jackson GD. New techniques in magnetic resonance and epilepsy. Epilepsia. 1994;35 Suppl 6:S2–13.
Spencer SS. The relative contributions of MRI, SPECT, and PET imaging in epilepsy. Epilepsia. 1994;35 Suppl 6:S72–89.
Schwartz ES, Dlugos DJ, Storm PB, et al. Magnetoencephalography for pediatric epilepsy: how we do it. AJNR Am J Neuroradiol. 2008;29(5):832–7.
Lau M, Yam D, Burneo JG. A systematic review on MEG and its use in the presurgical evaluation of localization-related epilepsy. Epilepsy Res. 2008;79(2–3):97–104.
The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 2010;333:1581–7.
Furlan A, Higashida R, Wechsler L, et al. Intra-arterial prourokinase for acute ischemic stroke: The PROACT II study—a randomized controlled trial. Prolyse in acute cerebral thromboembolism. JAMA. 1999;282:2003–11.
Kidwell CS, Warach S. Acute ischemic cerebrovascular syndrome: diagnostic criteria. Stroke. 2003;34:2995–8.
Easton JD, Saver JL, Albers GW, et al. Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease. Stroke. 2009;40:2276–93.
Restrepo L, Jacobs MA, Barker PB, Wityk RJ. Assessment of transient ischemic attack with diffusion- and perfusion-weighted imaging. AJNR Am J Neuroradiol. 2004;25:1645–52.
Albers GW. Acute cerebrovascular syndrome: time for new terminology for acute brain ischemia. Nat Clin Pract Cardiovasc Med. 2006;3:521.
Lloyd-Jones D, Adams R, Carnethon M, et al. Heart disease and stroke statistics—2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009;119(3):480–6.
Rothwell PM, Johnston SC. Transient ischemic attacks: stratifying risk. Stroke. 2006;37(2):320–2.
Wintermark M, Meuli R, Browaeys P, et al. Comparison of CT perfusion and angiography and MRI in selecting stroke patients for acute treatment. Neurology. 2007;68(9):694–7.
Siebert E, Bohner G, Dewey M, et al. 320-slice CT neuroimaging: initial clinical experience and image quality evaluation. Br J Radiol. 2009;82(979):561–70.
Goldstein LB, Adams R, Alberts MJ, et al. Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2006;113(24):e873–923.
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. JAMA 1995;273(18):1421–8.
Barnett HJ, Taylor DW, Eliasziw M, et al. Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med. 1998;339(20):1415–25.
Hobson 2nd RW, Weiss DG, Fields WS, et al. Efficacy of carotid endarterectomy for asymptomatic carotid stenosis. The Veterans Affairs Cooperative Study Group. N Engl J Med. 1993;328(4):221–7.
Rothwell PM, Eliasziw M, Gutnikov SA, et al. Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis. Lancet. 2003;361(9352):107–16.
Brott TG, Hobson 2nd RW, Howard G, et al. Stenting versus endarterectomy for treatment of carotid-artery stenosis. N Engl J Med. 2010;363(1):11–23.
Halliday A, Harrison M, Hayter E, et al. 10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosi (ACST-1): a multicentre randomised trial. Lancet. 2010;376(9746):1074–84.
Derdeyn CP, Powers WJ. Cost-effectiveness of screening for asymptomatic carotid atherosclerotic disease. Stroke. 1996;27(11):1944–50.
Obuchowski NA, Modic MT, Magdinec M, Masaryk TJ. Assessment of the efficacy of noninvasive screening for patients with asymptomatic neck bruits. Stroke. 1997;28(7):1330–9.
Mathiesen EB, Joakimsen O, Bonaa KH. Intersonographer reproducibility and intermethod variability of ultrasound measurements of carotid artery stenosis: The Tromso Study. Cerebrovasc Dis. 2000;10(3):207–13.
Wardlaw JM, Chappell FM, Best JJ, Wartolowska K, Berry E. Non-invasive imaging compared with intra-arterial angiography in the diagnosis of symptomatic carotid stenosis: a meta-analysis. Lancet. 2006;367(9521):1503–12.
Honish C, Sadanand V, Fladeland D, Chow V, Pirouzmand F. The reliability of ultrasound measurements of carotid stenosis compared to MRA and DSA. Can J Neurol Sci. 2005;2(4):465–71.
Barth A, Arnold M, Mattle HP, Schroth G, Remonda L. Contrastenhanced 3-D MRA in decision making for carotid endarterectomy: a 6-year experience. Cerebrovasc Dis. 2006;21(5–6):393–400.
U-King-Im JM, Hollingworth W, Trivedi RA, et al. Costeffectiveness of diagnostic strategies prior to carotid endarterectomy. Ann Neurol. 2005;58(4):506–15.
Bartlett ES, Walters TD, Symons SP, Fox AJ. Quantification of carotid stenosis on CT angiography. AJNR Am J Neuroradiol. 2006;27(1):13–9.
Koelemay MJ, Nederkoorn PJ, Reitsma JB, Majoie CB. Systematic review of computed tomographic angiography for assessment of carotid artery disease. Stroke. 2004;35(10):2306–12.
U-King-Im JM, Tang TY, Patterson A, et al. Characterisation of carotid atheroma in symptomatic and asymptomatic patients using high resolution MRI. J Neurol Neurosurg Psychiatry. 2008;79(8):905–12.
Wintermark M, Jawadi SS, Rapp JH, et al. High-resolution CT imaging of carotid artery atherosclerotic plaques. AJNR Am J Neuroradiol. 2008;29(5):875–82.
Derdeyn CP, Videen TO, Yundt KD, et al. Variability of cerebral blood volume and oxygen extraction: stages of cerebral haemodynamic impairment revisited. Brain. 2002;125(Pt 3):595–607.
Kuroda S, Shiga T, Houkin K, et al. Cerebral oxygen metabolism and neuronal integrity in patients with impaired vasoreactivity attributable to occlusive carotid artery disease. Stroke. 2006;37(2):393–8.
Nemoto EM, Yonas H, Kuwabara H, et al. Identification of hemodynamic compromise by cerebrovascular reserve and oxygen extraction fraction in occlusive vascular disease. J Cereb Blood Flow Metab. 2004;24(10):1081–9.
Endo H, Inoue T, Ogasawara K, Fukuda T, Kanbara Y, Ogawa A. Quantitative assessment of cerebral hemodynamics using perfusion-weighted MRI in patients with major cerebral artery occlusive disease: comparison with positron emission tomography. Stroke. 2006;37(2):388–92.
Furukawa M, Kashiwagi S, Matsunaga N, Suzuki M, Kishimoto K, Shirao S. Evaluation of cerebral perfusion parameters measured by perfusion CT in chronic cerebral ischemia: comparison with xenon CT. J Comput Assist Tomogr. 2002;26(2):272–8.
Adams H, Adams R, Del Zoppo G, Goldstein LB. Guidelines for the early management of patients with ischemic stroke: 2005 guidelines update a scientific statement from the Stroke Council of the American Heart Association/American Stroke Association. Stroke. 2005;36(4):916–23.
Hacke W, Donnan G, Fieschi C, et al. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet. 2004;363(9411):768–74.
Katzan IL, Hammer MD, Furlan AJ, Hixson ED, Nadzam DM. Quality improvement and tissue-type plasminogen activator for acute ischemic stroke: a Cleveland update. Stroke. 2003;34(3):799–800.
Reeves MJ, Arora S, Broderick JP, et al. Acute stroke care in the US: results from 4 pilot prototypes of the Paul Coverdell National Acute Stroke Registry. Stroke. 2005;36(6):1232–72.
Khatri P, Hill MD, Palesch YY, et al. Methodology of the Interventional Management of Stroke III Trial. Int J Stroke. 2008;3(2):130–7.
Mattle HP, Arnold M, Georgiadis D, et al. Comparison of intraarterial and intravenous thrombolysis for ischemic stroke with hyperdense middle cerebral artery sign. Stroke. 2008;39(2):379–83.
Smith WS, Sung G, Saver J, et al. Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial. Stroke. 2008;39(4):1205–12.
De Keyser J, Gdovinova Z, Uyttenboogaart M, Vroomen PC, Luijckx GJ. Intravenous alteplase for stroke: beyond the guidelines and in particular clinical situations. Stroke. 2007;38(9):2612–8.
Fiehler J, Albers GW, Boulanger JM, et al. Bleeding risk analysis in stroke imaging before thrombolysis (BRASIL): pooled analysis of T2*-weighted magnetic resonance imaging data from 570 patients. Stroke. 2007;38(10):2738–44.
Kohrmann M, Schellinger PD. Acute stroke triage to intravenous thrombolysis and other therapies with advanced CT or MR imaging: pro MR imaging. Radiology. 2009;251(3):627–33.
Adams Jr HP, del Zoppo G, Alberts MJ, et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke. 2007;38(5):1655–711.
Wardlaw JM, Mielke O. Early signs of brain infarction at CT: observer reliability and outcome after thrombolytic treatment—systematic review. Radiology. 2005;235(2):444–53.
Wintermark M, Rowley HA, Lev MH. Acute stroke triage to intravenous thrombolysis and other therapies with advanced CT or MR imaging: pro CT. Radiology. 2009;251(3):619–26.
Al-Okaili RN, Krejza J, Wang S, Woo JH, Melhem ER. Advanced MR imaging techniques in the diagnosis of intraaxial brain tumors in adults. Radiographics. 2006;26:S173–89.
Cross 3rd DT, Tirschwell DL, Clark MA, et al. Mortality rates after subarachnoid hemorrhage: variations according to hospital case volume in 18 states. J Neurosurg. 2003;99(5):810–7.
Flaherty ML, Haverbusch M, Sekar P, et al. Long-term mortality after intracerebral hemorrhage. Neurology. 2006;66(8):1182–6.
Black PM. Hydrocephalus and vasospasm after subarachnoid hemorrhage from ruptured intracranial aneurysms. Neurosurgery. 1986;18(1):12–6.
Kassell NF, Boarini DJ, Adams Jr HP, et al. Overall management of ruptured aneurysm: comparison of early and late operation. Neurosurgery. 1981;9(2):120–8.
Bederson JB, Connolly Jr ES, Batjer HH, et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a statement for healthcare professionals from a special writing group of the Stroke Council. American Heart Association. Stroke. 2009;40(3):994–1025.
Dammert S, Krings T, Moller-Hartmann W, et al. Detection of intracranial aneurysms with multislice CT: comparison with conventional angiography. Neuroradiology. 2004;46(6):427–34.
Jayaraman MV, Mayo-Smith WW, Tung GA, et al. Detection of intracranial aneurysms: multi-detector row CT angiography compared with DSA. Radiology. 2004;230(2):510–8.
Li Q, Lv F, Li Y, Luo T, Li K, Xie P. Evaluation of 64-section CT angiography for detection and treatment planning of intracranial aneurysms by using DSA and surgical findings. Radiology. 2009;252(3):808–15.
Dehdashti AR, Rufenacht DA, Delavelle J, Reverdin A, de Tribolet N. Therapeutic decision and management of aneurismal subarachnoid haemorrhage based on computed tomographic angiography. Br J Neurosurg. 2003;17(1):46–53.
Hoh BL, Cheung AC, Rabinov JD, Pryor JC, Carter BS, Ogilvy CS. Results of a prospective protocol of computed tomographic angiography in place of catheter angiography as the only diagnostic and pretreatment planning study for cerebral aneurysms by a combined neurovascular team. Neurosurgery. 2004;54(6):1329–40; discussion 1340–1322.
Aaslid R, Huber P, Nornes H. Evaluation of cerebrovascular spasm with transcranial Doppler ultrasound. J Neurosurg. 1984;60(1):37–41.
Kimura T, Shinoda J, Funakoshi T. Prediction of cerebral infarction due to vasospasm following aneurysmal subarachnoid haemorrhage using acetazolamide-activated 123I-IMP SPECT. Acta Neurochir (Wien). 1993;123(3–4):125–8.
Kistler JP, Crowell RM, Davis KR, et al. The relation of cerebral vasospasm to the extent and location of subarachnoid blood visualized by CT scan: a prospective study. Neurology. 1983;33(4):424–36.
Lewis DH, Eskridge JM, Newell DW, et al. Brain SPECT and the effect of cerebral angioplasty in delayed ischemia due to vasospasm. J Nucl Med. 1992;33(10):1789–96.
Sviri GE, Mesiwala AH, Lewis DH, et al. Dynamic perfusion computerized tomography in cerebral vasospasm following aneurysmal subarachnoid hemorrhage: a comparison with technetium-99 m-labeled ethyl cysteinate dimer-single-photon emission computerized tomography. J Neurosurg. 2006;104(3):404–10.
Wintermark M, Ko NU, Smith WS, Liu S, Higashida RT, Dillon WP. Vasospasm after subarachnoid hemorrhage: utility of perfusion CT and CT angiography on diagnosis and management. AJNR Am J Neuroradiol. 2006;27(1):26–34.
Pouratian N, Oskouian Jr RJ, Jensen ME, Kassell NF, Dumont AS. Endovascular management of unruptured intracranial aneurysms. J Neurol Neurosurg Psychiatry. 2006;77(5):572–8.
Wiebers DO, Whisnant JP, Huston 3rd J, et al. Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet. 2003;362(9378):103–10.
Molyneux AJ, Kerr RS, Yu LM, et al. International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet. 2005;366(9488):809–17.
Ruggieri PM, Poulos N, Masaryk TJ, et al. Occult intracranial aneurysms in polycystic kidney disease: screening with MR angiography. Radiology. 1994;191(1):33–9.
Ronkainen A, Puranen MI, Hernesniemi JA, et al. Intracranial aneurysms: MR angiographic screening in 400 asymptomatic individuals with increased familial risk. Radiology. 1995;195(1):35–40.
Marks MP, Lane B, Steinberg GK, Chang PJ. Hemorrhage in intracerebral arteriovenous malformations: angiographic determinants. Radiology. 1990;176(3):807–13.
Spetzler RF, Martin NA. A proposed grading system for arteriovenous malformations. J Neurosurg. 1986;65(4):476–83.
Cronqvist M, Wirestam R, Ramgren B, et al. Endovascular treatment of intracerebral arteriovenous malformations: procedural safety, complications, and results evaluated by MR imaging, including diffusion and perfusion imaging. AJNR Am J Neuroradiol. 2006;27(1):162–76.
Gupta V, Chugh M, Walia BS, Vaishya S, Jha AN. Use of CT angiography for anatomic localization of arteriovenous malformation Nidal components. AJNR Am J Neuroradiol. 2008;29(10):1837–40.
Lanzino G, Fraser K, Kanaan Y, Wagenbach A. Treatment of ruptured intracranial aneurysms since the International Subarachnoid Aneurysm Trial: practice utilizing clip ligation and coil embolization as individual or complementary therapies. J Neurosurg. 2006;104(3):344–9.
Molyneux AJ, Kerr RS, Yu LM, et al. International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet. 2005;36(9488):809–17.
Schaafsma JD, Koffijberg H, Buskens E, Velthuis BK, van der Graaf Y, Rinkel GJ. Cost-effectiveness of magnetic resonance angiography versus intra-arterial digital subtraction angiography to follow-up patients with coiled intracranial aneurysms. Stroke. 2010;41(8):1736–42.
Sprengers ME, Schaafsma JD, van Rooij WJ, et al. Evaluation of the occlusion status of coiled intracranial aneurysms with MR angiography at 3 T: is contrast enhancement necessary? AJNR Am J Neuroradiol. 2009;30(9):1665–71.
Shellock FG, Crues JV. MR procedures: biologic effects, safety, and patient care. Radiology. 2004;232(3):635–52.
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Shah, P.N. (2014). Neurological Imaging. In: Reinus, W. (eds) Clinician's Guide to Diagnostic Imaging. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8769-2_2
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