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Neuron–Glia Interaction via Neurotrophins

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Neuron-Glia Interaction in Neuroinflammation

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 7))

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Abstract

Initially described as target-derived survival factors for neurons, neurotrophins are now known to exert pleiotropic actions as they also regulate neuronal development, function, and plasticity. These processes however are not cell autonomous but derive from the complex interplay between neurons and glia cells.

In this chapter we offer an overview of the current knowledge on the functions supported by neurotrophins in neurons, and focus the attention on the role of neurotrophins in the cross talk between neurons and myelinating cells, microglia, and astrocytes.

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Abbreviations

BDNF:

Brain-derived neurotrophic factor

DRG:

Dorsal root ganglion

LINGO-1:

LRR and Ig domain containing nogo receptor interacting protein

LRR:

Leucine-rich repeats

LTD:

Long-term depression

LTP:

Long-term potentiation

MAG:

Myelin-associated glycoprotein

NGF:

Nerve growth factor

NgR:

Nogo receptor

NO:

Nitric oxide

NT:

Neurotrophin(s)

OL:

Oligodendrocyte(s)

OMgp:

Oligodendrocyte myelin glycoprotein

SC:

Schwann cell(s)

TK:

Tyrosine kinase

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Conflict of Interest

The author declares she has no conflict of interest. This chapter does not contain any studies with human or animal subjects.

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  1. Immunobiology of Neurological Disorders Lab, Division of Neuroscience and Institute of Experimental Neurology, San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy

    Cinthia Farina Ph.D.

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Correspondence to Cinthia Farina Ph.D. .

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  1. Department of Neuroimmunology Research Inst. of Environmental Medicine, Nagoya University, Nagoya, Japan

    Akio Suzumura

  2. Div of Neurobiology & Neuroinformatics, National Inst of Physiological Science, Aichi, Japan

    Kazuhiro Ikenaka

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Farina, C. (2013). Neuron–Glia Interaction via Neurotrophins. In: Suzumura, A., Ikenaka, K. (eds) Neuron-Glia Interaction in Neuroinflammation. Advances in Neurobiology, vol 7. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8313-7_7

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