Neuron-Glia Interaction in Neuroinflammation

  • Akio Suzumura
  • Kazuhiro Ikenaka

Part of the Advances in Neurobiology book series (NEUROBIOL, volume 7)

Table of contents

  1. Front Matter
    Pages i-x
  2. Tetsuya Mizuno
    Pages 49-62
  3. Cinthia Farina
    Pages 101-117
  4. Sung Joong Lee
    Pages 135-156
  5. Fumitaka Shimizu, Takashi Kanda
    Pages 157-179
  6. Back Matter
    Pages 181-187

About this book

Introduction

Accumulation of glia, gliosis, in various neurological disorders is not a static scar, but actively involved in pathogenesis of various neurological and psychiatric disorders, where glial cells produce both inflammatory and neurotrophic factors. These factors may play a role in neuronal damage, but also have a protective and reparative function by inducing neuroinflammation. However, definition as well as the mechanisms of neuroinflammation is not yet clear. We first define acute, chronic and non-classical neuroinflammation.

Glial cells are activated by a variety of stimuli via receptors on glial cells. Toll like receptors (TLR) are one of these receptors. In response to harmful stimuli, neurons produce factors as either “eat-me” or “help-me” signals. These factors include cytokines, chemokines and damage-associated molecular pattern (DAMP). Some of them activate glial cells via TLR, and function to protect neurons or further induce neuroinflammation. Thus, the interaction between neuron-glia and glia-glia is a main feature of neuroinflammation. Glial cells communicate with other glial or neural cells via gap-junctions. The communication may also be important for the understanding of neuroinflammation. Oligodendrocytes-neurons communication may be critical in either myelination or demyelination. Damage of blood-brain barrier (BBB) is common feature of both inflammatory and degenerative neurological disorders. Thus, relation of BBB damage and functions of glial cell may also be important in the development of neuroinflammation. 

In this book, we focused on neuron-glia interaction of various aspects for understanding of pathophysiology of neuroinflammation in development of inflammatory as well as degenerative neurological disorders.

Keywords

microglia neurodegeneration neuroinflammation neuron-glia interaction

Editors and affiliations

  • Akio Suzumura
    • 1
  • Kazuhiro Ikenaka
    • 2
  1. 1.Department of Neuroimmunology Research Inst. of Environmental MedicineNagoya UniversityNagoyaJapan
  2. 2.Div of Neurobiology & NeuroinformaticsNational Inst of Physiological ScienceAichiJapan

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-8313-7
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-8312-0
  • Online ISBN 978-1-4614-8313-7
  • Series Print ISSN 2190-5215
  • Series Online ISSN 2190-5223
  • About this book