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Gadd45 Stress Sensors in Preeclampsia

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Gadd45 Stress Sensor Genes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 793))

Abstract

Preeclampsia is a pregnancy-induced complex of multiple pathological changes. Numerous stresses during pregnancy, including hypoxia, immune activation, inflammatory cytokines, and oxidative stress were reported as contributing factors to the preeclamptic pathology. Seeking common sensors of various stressors in preeclampsia is of new interest and can potentially benefit in disease prevention and treatment. Recent studies have highlighted the role of the Gadd45a protein as a stress sensor in preeclampsia. In response to various pathophysiological stressors, notably hypoxia, inflammatory cytokines, and AT1-AAs, Gadd45a activates Mkk3-p38 and or JNK signaling. This, in turn, results in immunological and inflammatory changes as well as triggering the production of circulating factors such as sFlt-1, which are believed to account for many of the pathophysiological-related symptoms of preeclampsia. Activation of inflammatory/immune responses in preeclampsia may function in a feedback loop to maintain elevated expression of Gadd45a protein.

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Authors and Affiliations

  1. Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, USA

    Ossie Geifman-Holtzman M.D. & Yali Xiong M.D., Ph.D.

  2. Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PA, USA

    Ossie Geifman-Holtzman M.D.

  3. Nephrology and Hypertension Institute, Sheba Medical Center, Tel-Aviv University, Tel Hashomer, Israel

    Eliezer J. Holtzman M.D.

Authors
  1. Ossie Geifman-Holtzman M.D.
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  2. Yali Xiong M.D., Ph.D.
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  3. Eliezer J. Holtzman M.D.
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Correspondence to Ossie Geifman-Holtzman M.D. .

Editor information

Editors and Affiliations

  1. Professor of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Dan A. Liebermann

  2. Professor of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Barbara Hoffman

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Geifman-Holtzman, O., Xiong, Y., Holtzman, E.J. (2013). Gadd45 Stress Sensors in Preeclampsia. In: Liebermann, D., Hoffman, B. (eds) Gadd45 Stress Sensor Genes. Advances in Experimental Medicine and Biology, vol 793. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8289-5_7

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