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Catching the Next Wave: Patterning of the Drosophila Eye by the Morphogenetic Furrow

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Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye

Abstract

In 1864, August Weismann published the first drawing of the insect eye–antennal disc complex. In this image, he drew a line within the eye and described it as the border between the eye and antennal portions of the disc complex. One hundred and twelve years later, Donald Ready, Thomas Hanson, and Seymour Benzer demonstrated that this line, which they called the morphogenetic furrow, is actually the leading edge of a differentiating wave that traverses the eye disc of the fruit fly, Drosophila melanogaster, and transforms a field of undifferentiated and nonpatterned cells into an ordered array of periodically spaced ommatidia or unit eyes. In the 36 years since this seminal discovery, dozens of papers have focused on elucidating the molecular mechanisms that underlie the initiation and progression of the furrow as well as the many cellular changes that cells undergo as they enter, temporarily reside, and then exit the furrow. This review will summarize what is currently known about the cellular architecture of the furrow and the mechanisms that control its birth and propagation across the eye primordium. This chapter will also discuss the means by which the initiation of the furrow is restricted to a single point along the posterior margin.

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Acknowledgments

I would like to thank everyone who has contributed to our understanding of the mechanisms that regulate the initiation and progression of the morphogenetic furrow. I would like to also apologize to anyone whose work is not cited here. This work was supported by a grant from the National Eye Institute (R01 EY4863) to Justin P. Kumar.

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  1. Department of Biology, Indiana University, 47405, Bloomington, IN, USA

    Justin P. Kumar

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  1. Justin P. Kumar
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Correspondence to Justin P. Kumar .

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  1. Department of Biology, University of Dayton, Dayton, Ohio, USA

    Amit Singh

  2. Department of Biology Office: SC303C, University of Dayton, Dayton, Ohio, USA

    Madhuri Kango-Singh

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Kumar, J. (2013). Catching the Next Wave: Patterning of the Drosophila Eye by the Morphogenetic Furrow. In: Singh, A., Kango-Singh, M. (eds) Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8232-1_3

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