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PARP Activation and Necrotic Cell Death

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Necrotic Cell Death

Part of the book series: Cell Death in Biology and Diseases ((CELLDEATH))

Abstract

Poly(ADP-ribose) polymerase (PARP) protein family consists of at least 17 members. They catalyze the chemical reaction termed polyADP-ribosylation, which functions to cleave nicotinamide adenine dinucleotide into ADP-ribose and nicotinamide mononucleotide (NAM), and transfer ADP-ribose to glutamate, aspartate, or lysine residues on substrate proteins to form poly(ADP-ribosyl)ated chains. PARP proteins play an essential role in chromatin organization, DNA repair, replication, and transcriptional regulation. Upon excessive DNA damage, PARP is hyperactivated and causes cell death. This chapter summarizes the molecular regulation of cell death by PARP.

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Authors and Affiliations

  1. Department of Molecular Genetics & Microbiology, Stony Brook University, Stony Brook, NY, 11794, USA

    Yongjun Fan & Wei-Xing Zong

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  1. Yongjun Fan
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  2. Wei-Xing Zong
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Correspondence to Wei-Xing Zong .

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  1. Department of Physiology, National University of Singapore Yong Loo Lin School of Medicine, Singapore, Singapore

    Han-Ming Shen

  2. Department of Biomedical Molecular Biology (UGent), VIB/University of Ghent Inflammation Research Center (VIB), Zwijnaarde, Belgium

    Peter Vandenabeele

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Fan, Y., Zong, WX. (2014). PARP Activation and Necrotic Cell Death. In: Shen, HM., Vandenabeele, P. (eds) Necrotic Cell Death. Cell Death in Biology and Diseases. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-8220-8_9

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