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Targeting the Prostate Stem Cell for Chemoprevention

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Stem Cells and Prostate Cancer

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Abstract

Prostate cancer is the most common cancer diagnosis and the second deadliest non-cutaneous cancer in men in the western world. Despite the advancement of new therapies, survival rates remain tightly correlated to the stage in which a patient is diagnosed. The heterogeneous nature of tumor and their variable response to therapies is now being attributed to tumor-initiating cells or cancer stem cells. The cancer stem cell hypothesis suggests that cancer initiates from a specific subset of tumor cells that possess “stemlike” properties. Over the past several decades, the use of natural or synthetic agents such as vitamins, foods, or spices has been shown to correlate with lower incidences of cancer. Many of these chemopreventive agents have now been reported to cause differentiation of cancer stem cells and suppress their proliferation, thereby making them more amenable to conventional therapies. This chapter will discuss the use of chemoprevention to target cancer stem cells and how these approaches can be applied to prostate cancer.

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  1. Department of Pharmacology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA

    Molishree U. Joshi Ph.D., Courtney K. von Bergen Ph.D. & Scott D. Cramer Ph.D.

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    Scott D. Cramer

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Joshi, M.U., von Bergen, C.K., Cramer, S.D. (2013). Targeting the Prostate Stem Cell for Chemoprevention. In: Cramer, S. (eds) Stem Cells and Prostate Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6498-3_8

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