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Characterization of MSCs: From Early Studies to the Present

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Mesenchymal Stromal Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Studies on mesenchymal stem cells/mesenchymal stromal cells (MSCs) have increased dramatically in the last 10 years, and many clinical trials are underway to take advantage of their properties. Early studies on MSC-like cells were performed in laboratories studying either bone repair or hematopoiesis, but the overlap in these studies was not broadly appreciated. The relationship between MSCs, osteoblastic progenitor cells, and the bone marrow stromal cells that provide support for hematopoietic stem cells has emerged. A variety of assays, in vitro and in vivo, allowed for a broader understanding of the MSCs and their characteristics. The MSCs from different animal species have properties similar to those from man, and this has allowed for many animal studies that provided preclinical support for human clinical trials with MSCs. While there are many established characteristics, new understanding of the MSC and the interaction of MSCs with other cell types, including HSCs and those of the immune system, will continue to reveal new and useful understanding of MSC properties.

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Authors and Affiliations

  1. Department of Surgery/Cardiac, University of Maryland School of Medicine, Baltimore, MD, 21201, USA

    Mark F. Pittenger Ph.D.

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  1. Mark F. Pittenger Ph.D.
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Correspondence to Mark F. Pittenger Ph.D. .

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  1. Madison School of Medicine and Public He, Department of Medicine, Hematology/Oncol, University of Wisconsin, 1111 Highland Avenue MC2275, Madison, 53705, USA

    Peiman Hematti

  2. Princess Margaret Hospital, Cell Therapy Program, University of Toronto, University Avenue 610, Toronto, M5G 2M9, Ontario, Canada

    Armand Keating

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Pittenger, M.F. (2013). Characterization of MSCs: From Early Studies to the Present. In: Hematti, P., Keating, A. (eds) Mesenchymal Stromal Cells. Stem Cell Biology and Regenerative Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-5711-4_4

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