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Consequences of Developmental Stress in Humans: Adversity Experienced During Childhood and Adolescence

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Adaptive and Maladaptive Aspects of Developmental Stress

Part of the book series: Current Topics in Neurotoxicity ((Current Topics Neurotoxicity,volume 3))

Abstract

Early life stress is a term used to describe adversities which may occur during childhood and adolescence. The majority of human studies focus on negative outcomes resulting from early life stress. There is an emerging research field which aims to investigate possible positive outcomes of early life stress. In this chapter, human studies are reviewed with regard to both maladaptive and adaptive consequences of early life stress. Recent findings suggest that early life stress is associated with central nervous alterations, altered physiological stress responses, impaired cognitive functioning as well as an increased risk of developing behavior problems, and somatic and psychiatric illnesses. Early life stress may also result in posttraumatic growth (PTG) which describes changes in self-perception, interpersonal relationships, and worldview. A psychobiological stress model is proposed to integrate the findings.

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References

  • Alisic E, van der Schoot TA, van Ginkel JR, Kleber RJ (2008) Looking beyond posttraumatic stress disorder in children: posttraumatic stress reactions, posttraumatic growth, and quality of life in a general population sample. J Clin Psychiatry 69(9):1455–1461

    Article  PubMed  Google Scholar 

  • APA (2000) Diagnostic statistical manual of mental disorders (Revised 4th edition). Author, Washington, DC

    Google Scholar 

  • Barakat LP, Alderfer MA, Kazak AE (2006) Posttraumatic growth in adolescent survivors of cancer and their mothers and fathers. J Pediatr Psychol 31(4):413–419

    Article  PubMed  Google Scholar 

  • Beach SR, Brody GH, Gunter TD, Packer H, Wernett P, Philibert RA (2010a) Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder. J Fam Psychol 24(1):12–20

    Article  PubMed  Google Scholar 

  • Beach SR, Brody GH, Todorov AA, Gunter TD, Philibert RA (2010b) Methylation at SLC6A4 is linked to family history of child abuse: an examination of the Iowa adoptee sample. Am J Med Genet B Neuropsychiatr Genet 153B(2):710–713

    CAS  PubMed  Google Scholar 

  • Beach SR, Brody GH, Todorov AA, Gunter TD, Philibert RA (2011) Methylation at 5HTT mediates the impact of child sex abuse on women's antisocial behavior: an examination of the Iowa adoptee sample. Psychosom Med 73(1):83–87

    Article  CAS  PubMed  Google Scholar 

  • Bernard K, Butzin-Dozier Z, Rittenhouse J, Dozier M (2010) Cortisol production patterns in young children living with birth parents vs children placed in foster care following involvement of Child Protective Services. Arch Pediatr Adolesc Med 164(5):438–443

    PubMed  Google Scholar 

  • Bet PM, Penninx BWJH, Bochdanovits Z, Uitterlinden AG, Beekman ATF, van Schoor NM etal (2009) Glucocorticoid receptor gene polymorphisms and childhood adversity are associated with depression: new evidence for a gene-environment interaction. Am J Med Genet B Neuropsychiatr Genet 150B(5):660–669

    Article  CAS  PubMed  Google Scholar 

  • Binder EB, Bradley RG, Liu W, Epstein MP, Deveau TC, Mercer KB etal (2008) Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA 299(11):1291–1305

    Article  CAS  PubMed  Google Scholar 

  • Bos KJ, Fox N, Zeanah CH, Nelson CA (2009) Effects of early psychosocial deprivation on the development of memory and executive function. Front Behav Neurosci 3:16

    PubMed  Google Scholar 

  • Bradley RG, Binder EB, Epstein MP, Tang Y, Nair HP, Liu W etal (2008) Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry 65(2):190–200

    Article  CAS  PubMed  Google Scholar 

  • Bremner JD, Randall P, Scott TM, Capelli S, Delaney R, McCarthy G etal (1995) Deficits in short-term memory in adult survivors of childhood abuse. Psychiatry Res 59(1–2):97–107

    Article  CAS  PubMed  Google Scholar 

  • Bremner JD, Narayan M, Staib LH, Southwick SM, McGlashan T, Charney DS (1999) Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder. Am J Psychiatry 156(11):1787–1795

    CAS  PubMed  Google Scholar 

  • Carpenter LL, Tyrka AR, Ross NS, Khoury L, Anderson GM, Price LH (2009) Effect of childhood emotional abuse and age on cortisol responsivity in adulthood. Biol Psychiatry 66(1):69–75

    Article  CAS  PubMed  Google Scholar 

  • Carpenter LL, Gawuga CE, Tyrka AR, Lee JK, Anderson GM, Price LH (2010) Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults. Neuropsychopharmacology 35(13):2617–2623

    Article  CAS  PubMed  Google Scholar 

  • Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW etal (2002) Role of genotype in the cycle of violence in maltreated children. Science 297(5582):851–854

    Article  CAS  PubMed  Google Scholar 

  • Chandy JM, Blum RW, Resnick MD (1996) Gender-specific outcomes for sexually abused adolescents. Child Abuse Negl 20(12):1219–1231

    Article  CAS  PubMed  Google Scholar 

  • Chisholm K (1998) A three year follow-up of attachment and indiscriminate friendliness in children adopted from Romanian orphanages. Child Dev 69(4):1092–1106

    CAS  PubMed  Google Scholar 

  • Chrousos GP (2009) Stress and disorders of the stress system. Nat Rev Endocrinol 5(7):374–381

    Article  CAS  PubMed  Google Scholar 

  • Chugani HT, Behen ME, Muzik O, Juhasz C, Nagy F, Chugani DC (2001) Local brain functional activity following early deprivation: a study of postinstitutionalized Romanian orphans. Neuroimage 14(6):1290–1301

    Article  CAS  PubMed  Google Scholar 

  • Cicchetti D, Rogosch FA (2001) Diverse patterns of neuroendocrine activity in maltreated children. Dev Psychopathol 13(3):677–693

    Article  CAS  PubMed  Google Scholar 

  • Cirulli F, Francia N, Berry A, Aloe L, Alleva E, Suomi SJ (2009) Early life stress as a risk factor for mental health: role of neurotrophins from rodents to non-human primates. Neurosci Biobehav Rev 33(4):573–585

    Article  CAS  PubMed  Google Scholar 

  • Cohen RA, Grieve S, Hoth KF, Paul RH, Sweet L, Tate D etal (2006) Early life stress and morphometry of the adult anterior cingulate cortex and caudate nuclei. Biol Psychiatry 59(10):975–982

    Article  PubMed  Google Scholar 

  • Cryder CH, Kilmer RP, Tedeschi RG, Calhoun LG (2006) An exploratory study of posttraumatic growth in children following a natural disaster. Am J Orthopsychiatry 76(1):65–69

    Article  PubMed  Google Scholar 

  • Danese A, Moffitt TE, Harrington H, Milne BJ, Polanczyk G, Pariante CM etal (2009) Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers. Arch Pediatr Adolesc Med 163(12):1135–1143

    PubMed  Google Scholar 

  • De Bellis MD, Hall J, Boring AM, Frustaci K, Moritz G (2001) A pilot longitudinal study of hippocampal volumes in pediatric maltreatment-related posttraumatic stress disorder. Biol Psychiatry 50(4):305–309

    Article  PubMed  Google Scholar 

  • De Bellis MD, Keshavan MS, Shifflett H, Iyengar S, Beers SR, Hall J etal (2002) Brain structures in pediatric maltreatment-related posttraumatic stress disorder: a sociodemographically matched study. Biol Psychiatry 52(11):1066–1078

    Article  PubMed  Google Scholar 

  • Devine KA, Reed-Knight B, Loiselle KA, Fenton N, Blount RL (2010) Posttraumatic growth in young adults who experienced serious childhood illness: a mixed-methods approach. J Clin Psychol Med Settings 17(4):340–348

    Article  PubMed  Google Scholar 

  • Ditzen B, Nater UM, Heim C (2013) HPA axis challenge tests. In: Gellman MD, Turner JR (eds) Encyclopedia of behavioral medicine, Springer, Berlin pp. 1468–1471

    Google Scholar 

  • Drury SS, Theall K, Gleason MM, Smyke AT, De Vivo I, Wong JY etal (2011) Telomere length and early severe social deprivation: linking early adversity and cellular aging. Mol Psychiatry 17(7):719–27

    Article  PubMed  CAS  Google Scholar 

  • Dube SR, Anda RF, Felitti VJ, Chapman DP, Williamson DF, Giles WH (2001) Childhood abuse, household dysfunction, and the risk of attempted suicide throughout the life span: findings from the Adverse Childhood Experiences Study. JAMA 286(24):3089–3096

    Article  CAS  PubMed  Google Scholar 

  • Dube SR, Fairweather D, Pearson WS, Felitti VJ, Anda RF, Croft JB (2009) Cumulative childhood stress and autoimmune diseases in adults. Psychosom Med 71(2):243–250

    Article  PubMed  Google Scholar 

  • Elzinga BM, Schmahl CG, Vermetten E, van Dyck R, Bremner JD (2003) Higher cortisol levels following exposure to traumatic reminders in abuse-related PTSD. Neuropsychopharmacology 28(9):1656–1665

    Article  CAS  PubMed  Google Scholar 

  • Elzinga BM, Roelofs K, Tollenaar MS, Bakvis P, van Pelt J, Spinhoven P (2008) Diminished cortisol responses to psychosocial stress associated with lifetime adverse events a study among healthy young subjects. Psychoneuroendocrinology 33(2):227–237

    Article  CAS  PubMed  Google Scholar 

  • Feder A, Nestler EJ, Charney DS (2009) Psychobiology and molecular genetics of resilience. Nat Rev Neurosci 10(6):446–457

    Article  CAS  PubMed  Google Scholar 

  • Flaherty EG, Thompson R, Litrownik AJ, Theodore A, English DJ, Black MM etal (2006) Effect of early childhood adversity on child health. Arch Pediatr Adolesc Med 160(12):1232–1238

    Article  PubMed  Google Scholar 

  • Fujiwara T, Kawakami N, World Mental Health Japan Survey Group (2011) Association of childhood adversities with the first onset of mental disorders in Japan: results from the World Mental Health Japan, 2002–2004. J Psychiatr Res 45(4):481–487

    Article  PubMed  Google Scholar 

  • Fuller-Thomson E, Brennenstuhl S, Frank J (2010) The association between childhood physical abuse and heart disease in adulthood: findings from a representative community sample. Child Abuse Negl 34(9):689–698

    Article  PubMed  Google Scholar 

  • Furukawa T, Harai H, Hirai T, Fujihara S, Kitamura T, Takahashi K (1998) Childhood parental loss and alcohol dependence among Japanese men: a case–control study. Group for Longitudinal Affective Disorders Study (GLADS). Acta Psychiatr Scand 97(6):403–407

    Article  CAS  PubMed  Google Scholar 

  • Gunnar MR, Morison SJ, Chisholm K, Schuder M (2001) Salivary cortisol levels in children adopted from Romanian orphanages. Dev Psychopathol 13(3):611–628

    Article  CAS  PubMed  Google Scholar 

  • Gunstad J, Paul RH, Spitznagel MB, Cohen RA, Williams LM, Kohn M etal (2006) Exposure to early life trauma is associated with adult obesity. Psychiatry Res 142(1):31–37

    Article  PubMed  Google Scholar 

  • Hafstad GS, Gil-Rivas V, Kilmer RP, Raeder S (2010) Parental adjustment, family functioning, and posttraumatic growth among Norwegian children and adolescents following a natural disaster. Am J Orthopsychiatry 80(2):248–257

    Article  PubMed  Google Scholar 

  • Handa M, Nukina H, Hosoi M, Kubo C (2008) Childhood physical abuse in outpatients with psychosomatic symptoms. Biopsychosoc Med 2:8

    Article  PubMed  Google Scholar 

  • Hanson JL, Chung MK, Avants BB, Shirtcliff EA, Gee JC, Davidson RJ etal (2010) Early stress is associated with alterations in the orbitofrontal cortex: a tensor-based morphometry investigation of brain structure and behavioral risk. J Neurosci 30(22):7466–7472

    Article  CAS  PubMed  Google Scholar 

  • Heim C, Newport DJ, Heit S, Graham YP, Wilcox M, Bonsall R etal (2000) Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. JAMA 284(5):592–597

    Article  CAS  PubMed  Google Scholar 

  • Heim C, Newport DJ, Bonsall R, Miller AH, Nemeroff CB (2001) Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse. Am J Psychiatry 158(4):575–581

    Article  CAS  PubMed  Google Scholar 

  • Heim C, Newport DJ, Wagner D, Wilcox MM, Miller AH, Nemeroff CB (2002) The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis. Depress Anxiety 15(3):117–125

    Article  PubMed  Google Scholar 

  • Heim C, Wagner D, Maloney E, Papanicolaou DA, Solomon L, Jones JF etal (2006) Early adverse experience and risk for chronic fatigue syndrome: results from a population-based study. Arch Gen Psychiatry 63(11):1258–1266

    Article  PubMed  Google Scholar 

  • Heim C, Mletzko T, Purselle D, Musselman DL, Nemeroff CB (2008a) The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma. Biol Psychiatry 63(4):398–405

    Article  CAS  PubMed  Google Scholar 

  • Heim C, Newport DJ, Mletzko T, Miller AH, Nemeroff CB (2008b) The link between childhood trauma and depression: insights from HPA axis studies in humans. Psychoneuroendocrinology 33(6):693–710

    Article  CAS  PubMed  Google Scholar 

  • Heim C, Bradley B, Mletzko TC, Deveau TC, Musselman DL, Nemeroff CB etal (2009a) Effect of childhood trauma on adult depression and neuroendocrine function: sex-specific moderation by CRH receptor 1 gene. Front Behav Neurosci 3:41

    PubMed  Google Scholar 

  • Heim C, Nater UM, Maloney E, Boneva R, Jones JF, Reeves WC (2009b) Childhood trauma and risk for chronic fatigue syndrome: association with neuroendocrine dysfunction. Arch Gen Psychiatry 66(1):72–80

    Article  PubMed  Google Scholar 

  • Heim C, Young LJ, Newport DJ, Mletzko T, Miller AH, Nemeroff CB (2009c) Lower CSF oxytocin concentrations in women with a history of childhood abuse. Mol Psychiatry 14(10):954–958

    Article  CAS  PubMed  Google Scholar 

  • Ho SM, Chu KW, Yiu J (2008) The relationship between explanatory style and posttraumatic growth after bereavement in a non-clinical sample. Death Stud 32(5):461–478

    Article  PubMed  Google Scholar 

  • Huey SJ Jr, Weisz JR (1997) Ego control, ego resiliency, and the five-factor model as predictors of behavioral and emotional problems in clinic-referred children and adolescents. J Abnorm Psychol 106(3):404–415

    Article  PubMed  Google Scholar 

  • Johnson JG, Cohen P, Brown J, Smailes EM, Bernstein DP (1999) Childhood maltreatment increases risk for personality disorders during early adulthood. Arch Gen Psychiatry 56(7):600–606

    Article  CAS  PubMed  Google Scholar 

  • Jouriles EN, Barling J, Oleary KD (1987) Predicting child-behavior problems in maritally violent families. J Abnorm Child Psychol 15(2):165–173

    Article  CAS  PubMed  Google Scholar 

  • Kamibeppu K, Sato I, Honda M, Ozono S, Sakamoto N, Iwai T etal (2010) Mental health among young adult survivors of childhood cancer and their siblings including posttraumatic growth. J Cancer Surviv 4(4):303–312

    Article  PubMed  Google Scholar 

  • Kananen L, Surakka I, Pirkola S, Suvisaari J, Lonnqvist J, Peltonen L etal (2010) Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls. PLoS One 5(5):e10826

    Article  PubMed  CAS  Google Scholar 

  • Kaufman J, Birmaher B, Perel J, Dahl RE, Moreci P, Nelson B etal (1997) The corticotropin-releasing hormone challenge in depressed abused, depressed nonabused, and normal control children. Biol Psychiatry 42(8):669–679

    Article  CAS  PubMed  Google Scholar 

  • Kendler KS, Bulik CM, Silberg J, Hettema JM, Myers J, Prescott CA (2000) Childhood sexual abuse and adult psychiatric and substance use disorders in women: an epidemiological and cotwin control analysis. Arch Gen Psychiatry 57(10):953–959

    Article  CAS  PubMed  Google Scholar 

  • Kendler KS, Kuhn JW, Prescott CA (2004) Childhood sexual abuse, stressful life events and risk for major depression in women. Psychol Med 34(8):1475–1482

    Article  PubMed  Google Scholar 

  • Kiecolt-Glaser JK, Gouin JP, Weng NP, Malarkey WB, Beversdorf DQ, Glaser R (2011) Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation. Psychosom Med 73(1):16–22

    Article  PubMed  Google Scholar 

  • Kilmer RP, Gil-Rivas V (2010) Exploring posttraumatic growth in children impacted by Hurricane Katrina: correlates of the phenomenon and developmental considerations. Child Dev 81(4):1211–1227

    Article  PubMed  Google Scholar 

  • Kilmer RP, Gil-Rivas V, Tedeschi RG, Cann A, Calhoun LG, Buchanan T etal (2009) Use of the revised posttraumatic growth inventory for children. J Trauma Stress 22(3):248–253

    Article  PubMed  Google Scholar 

  • Kim J, Cicchetti D, Rogosch FA, Manly JT (2009) Child maltreatment and trajectories of personality and behavioral functioning: implications for the development of personality disorder. Dev Psychopathol 21(3):889–912

    Article  PubMed  Google Scholar 

  • King JA, Mandansky D, King S, Fletcher KE, Brewer J (2001) Early sexual abuse and low cortisol. Psychiatry Clin Neurosci 55(1):71–74

    Article  CAS  PubMed  Google Scholar 

  • Klaassens ER, van Noorden MS, Giltay EJ, van Pelt J, van Veen T, Zitman FG (2009) Effects of childhood trauma on HPA-axis reactivity in women free of lifetime psychopathology. Prog Neuropsychopharmacol Biol Psychiatry 33(5):889–894

    Article  CAS  PubMed  Google Scholar 

  • Kudielka BM, Wust S (2010) Human models in acute and chronic stress: assessing determinants of individual hypothalamus-pituitary-adrenal axis activity and reactivity. Stress 13(1):1–14

    Article  PubMed  Google Scholar 

  • Kunugi H, Sugawara N, Aoki H, Nanko S, Hirose T, Kazamatsuri H (1995) Early parental loss and depressive disorder in Japan. Eur Arch Psychiatry Clin Neurosci 245(2):109–113

    Article  CAS  PubMed  Google Scholar 

  • Lampe A, Doering S, Rumpold G, Solder E, Krismer M, Kantner-Rumplmair W etal (2003) Chronic pain syndromes and their relation to childhood abuse and stressful life events. J Psychosom Res 54(4):361–367

    Article  PubMed  Google Scholar 

  • Lanier P, Jonson-Reid M, Stahlschmidt MJ, Drake B, Constantino J (2010) Child maltreatment and pediatric health outcomes: a longitudinal study of low-income children. J Pediatr Psychol 35(5):511–522

    Article  PubMed  Google Scholar 

  • Lansford JE, Miller-Johnson S, Berlin LJ, Dodge KA, Bates JE, Pettit GS (2007) Early physical abuse and later violent delinquency: a prospective longitudinal study. Child Maltreat 12(3):233–245

    Article  PubMed  Google Scholar 

  • Laufer A, Solomon Z, Levine SZ (2010) Elaboration on posttraumatic growth in youth exposed to terror: the role of religiosity and political ideology. Soc Psychiatry Psychiatr Epidemiol 45(6):647–653

    Article  PubMed  Google Scholar 

  • Letzring TD, Block J, Funder DC (2005) Ego-control and ego-resiliency: generalization of self-report scales based on personality descriptions from acquaintances, clinicians, and the self. J Res Pers 39(4):395–422

    Article  Google Scholar 

  • Levine SZ, Laufer A, Hamama-Raz Y, Stein E, Solomon Z (2008) Posttraumatic growth in adolescence: examining its components and relationship with PTSD. J Trauma Stress 21(5):492–496

    Article  PubMed  Google Scholar 

  • Levine SZ, Laufer A, Stein E, Hamama-Raz Y, Solomon Z (2009) Examining the relationship between resilience and posttraumatic growth. J Trauma Stress 22(4):282–286

    Article  PubMed  Google Scholar 

  • Lovallo WR, Farag NH, Sorocco KH, Cohoon AJ, Vincent AS (2012) Lifetime adversity leads to blunted stress axis reactivity: studies from the oklahoma family health patterns project. Biol Psychiatry 71(4):344–349

    Article  PubMed  Google Scholar 

  • Luecken LJ (1998) Childhood attachment and loss experiences affect adult cardiovascular and cortisol function. Psychosom Med 60(6):765–772

    CAS  PubMed  Google Scholar 

  • MacMillan HL, Georgiades K, Duku EK, Shea A, Steiner M, Niec A etal (2009) Cortisol response to stress in female youths exposed to childhood maltreatment: results of the youth mood project. Biol Psychiatry 66(1):62–68

    Article  PubMed  Google Scholar 

  • Maikovich-Fong AK, Jaffee SR (2010) Sex differences in childhood sexual abuse characteristics and victims' emotional and behavioral problems: findings from a national sample of youth. Child Abuse Negl 34(6):429–437

    Article  PubMed  Google Scholar 

  • Majer M, Nater UM, Lin JM, Capuron L, Reeves WC (2010) Association of childhood trauma with cognitive function in healthy adults: a pilot study. BMC Neurol 10:61

    Article  PubMed  Google Scholar 

  • McEwen BS, Seeman T (1999) Protective and damaging effects of mediators of stress. Elaborating and testing the concepts of allostasis and allostatic load. Ann N Y Acad Sci 896:30–47

    Article  CAS  PubMed  Google Scholar 

  • Meinlschmidt G, Heim C (2005) Decreased cortisol awakening response after early loss experience. Psychoneuroendocrinology 30(6):568–576

    Article  CAS  PubMed  Google Scholar 

  • Meyerson DA, Grant KE, Carter JS, Kilmer RP (2011) Posttraumatic growth among children and adolescents: a systematic review. Clin Psychol Rev 31(6):949–964

    Article  PubMed  Google Scholar 

  • Mills R, Alati R, O'Callaghan M, Najman JM, Williams GM, Bor W etal (2011) Child abuse and neglect and cognitive function at 14 years of age: findings from a birth cohort. Pediatrics 127(1):4–10

    Article  PubMed  Google Scholar 

  • Moran P, Coffey C, Chanen A, Mann A, Carlin JB, Patton GC (2011) Childhood sexual abuse and abnormal personality: a population-based study. Psychol Med 41(06):1311–1318

    Article  PubMed  Google Scholar 

  • Morina N, von Lersner U, Prigerson HG (2011) War and bereavement: consequences for mental and physical distress. PLoS One 6(7):e22140

    Article  CAS  PubMed  Google Scholar 

  • Navalta CP, Polcari A, Webster DM, Boghossian A, Teicher MH (2006) Effects of childhood sexual abuse on neuropsychological and cognitive function in college women. J Neuropsychiatry Clin Neurosci 18(1):45–53

    Article  PubMed  Google Scholar 

  • Nelson EC, Heath AC, Madden PA, Cooper ML, Dinwiddie SH, Bucholz KK etal (2002) Association between self-reported childhood sexual abuse and adverse psychosocial outcomes: results from a twin study. Arch Gen Psychiatry 59(2):139–145

    Article  PubMed  Google Scholar 

  • Nelson CA, Zeanah CH, Fox NA, Marshall PJ, Smyke AT, Guthrie D (2007) Cognitive recovery in socially deprived young children: the Bucharest Early Intervention Project. Science 318(5858):1937–1940

    Article  CAS  PubMed  Google Scholar 

  • Newport DJ, Heim C, Bonsall R, Miller AH, Nemeroff CB (2004) Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse. Biol Psychiatry 55(1):10–20

    Article  CAS  PubMed  Google Scholar 

  • Nicolson NA, Davis MC, Kruszewski D, Zautra AJ (2010) Childhood maltreatment and diurnal cortisol patterns in women with chronic pain. Psychosom Med 72(5):471–480

    Article  PubMed  Google Scholar 

  • O'Donovan A, Epel E, Lin J, Wolkowitz O, Cohen B, Maguen S etal (2011) Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder. Biol Psychiatry 70(5):465–71

    Article  PubMed  CAS  Google Scholar 

  • O'Mahony SM, Marchesi JR, Scully P, Codling C, Ceolho AM, Quigley EM etal (2009) Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses. Biol Psychiatry 65(3):263–267

    Article  PubMed  Google Scholar 

  • Opacka-Juffry J, Mohiyeddini C (2011) Experience of stress in childhood negatively correlates with plasma oxytocin concentration in adult men. Stress 15(1):1–10

    PubMed  Google Scholar 

  • Ozbay F, Johnson DC, Dimoulas E, Morgan CA, Charney D, Southwick S (2007) Social support and resilience to stress: from neurobiology to clinical practice. Psychiatry (Edgmont) 4(5):35–40

    Google Scholar 

  • Patton GC, Coffey C, Posterino M, Carlin JB, Bowes G (2003) Life events and early onset depression: cause or consequence? Psychol Med 33(7):1203–1210

    Article  CAS  PubMed  Google Scholar 

  • Pollak SD, Nelson CA, Schlaak MF, Roeber BJ, Wewerka SS, Wiik KL etal (2010) Neurodevelopmental effects of early deprivation in postinstitutionalized children. Child Dev 81(1):224–236

    Article  PubMed  Google Scholar 

  • Rao U, Hammen C, Ortiz LR, Chen LA, Poland RE (2008) Effects of early and recent adverse experiences on adrenal response to psychosocial stress in depressed adolescents. Biol Psychiatry 64(6):521–526

    Article  CAS  PubMed  Google Scholar 

  • Romans S, Belaise C, Martin J, Morris E, Raffi A (2002) Childhood abuse and later medical disorders in women. An epidemiological study. Psychother Psychosom 71(3):141–150

    Article  PubMed  Google Scholar 

  • Salter E, Stallard P (2004) Posttraumatic growth in child survivors of a road traffic accident. J Trauma Stress 17(4):335–340

    Article  PubMed  Google Scholar 

  • Schilling EA, Aseltine RH Jr, Gore S (2007) Adverse childhood experiences and mental health in young adults: a longitudinal survey. BMC Public Health 7:30

    Article  PubMed  Google Scholar 

  • Schmidt MV, Wang XD, Meijer OC (2011) Early life stress paradigms in rodents: potential animal models of depression? Psychopharmacology (Berl) 214(1):131–140

    Article  CAS  Google Scholar 

  • Shakespeare-Finch J, de Dassel T (2009) Exploring posttraumatic outcomes as a function of childhood sexual abuse. J Child Sex Abus 18(6):623–640

    Article  PubMed  Google Scholar 

  • Silberg J, Rutter M, Neale M, Eaves L (2001) Genetic moderation of environmental risk for depression and anxiety in adolescent girls. Br J Psychiatry 179:116–121

    Article  CAS  PubMed  Google Scholar 

  • Silverman AB, Reinherz HZ, Giaconia RM (1996) The long-term sequelae of child and adolescent abuse: a longitudinal community study. Child Abuse Negl 20(8):709–723

    Article  CAS  PubMed  Google Scholar 

  • Stein MB, Koverola C, Hanna C, Torchia MG, McClarty B (1997) Hippocampal volume in women victimized by childhood sexual abuse. Psychol Med 27(4):951–959

    Article  CAS  PubMed  Google Scholar 

  • Tedeschi RG, Calhoun LG (1996) The Posttraumatic Growth Inventory: measuring the positive legacy of trauma. J Trauma Stress 9(3):455–471

    Article  CAS  PubMed  Google Scholar 

  • Teicher MH, Dumont NL, Ito Y, Vaituzis C, Giedd JN, Andersen SL (2004) Childhood neglect is associated with reduced corpus callosum area. Biol Psychiatry 56(2):80–85

    Article  PubMed  Google Scholar 

  • Thompson R, Tabone JK (2010) The impact of early alleged maltreatment on behavioral trajectories. Child Abuse Negl 34(12):907–916

    Article  PubMed  Google Scholar 

  • Thornberry TP, Henry KL, Ireland TO, Smith CA (2010) The causal impact of childhood-limited maltreatment and adolescent maltreatment on early adult adjustment. J Adolesc Health 46(4):359–365

    Article  PubMed  Google Scholar 

  • Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR etal (2010) Childhood maltreatment and migraine (part III). Association with comorbid pain conditions. Headache 50(1):42–51

    Article  PubMed  Google Scholar 

  • Turner-Sack AM, Menna R, Setchell SR (2012) Posttraumatic growth, coping strategies, and psychological distress in adolescent survivors of cancer. J Pediatr Oncol Nurs 29(2):70–79

    Article  PubMed  Google Scholar 

  • Tyrka AR, Wier L, Price LH, Ross N, Anderson GM, Wilkinson CW etal (2008) Childhood parental loss and adult hypothalamic-pituitary-adrenal function. Biol Psychiatry 63(12):1147–1154

    Article  CAS  PubMed  Google Scholar 

  • Tyrka AR, Wyche MC, Kelly MM, Price LH, Carpenter LL (2009) Childhood maltreatment and adult personality disorder symptoms: influence of maltreatment type. Psychiatry Res 165(3):281–287

    Article  PubMed  Google Scholar 

  • Tyrka AR, Price LH, Kao HT, Porton B, Marsella SA, Carpenter LL (2010) Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging. Biol Psychiatry 67(6):531–534

    Article  CAS  PubMed  Google Scholar 

  • van der Vegt EJ, van der Ende J, Kirschbaum C, Verhulst FC, Tiemeier H (2009) Early neglect and abuse predict diurnal cortisol patterns in adults A study of international adoptees. Psychoneuroendocrinology 34(5):660–669

    Article  PubMed  CAS  Google Scholar 

  • van der Vegt EJ, van der Ende J, Huizink AC, Verhulst FC, Tiemeier H (2010) Childhood adversity modifies the relationship between anxiety disorders and cortisol secretion. Biol Psychiatry 68(11):1048–1054

    Article  PubMed  CAS  Google Scholar 

  • Vythilingam M, Heim C, Newport J, Miller AH, Anderson E, Bronen R etal (2002) Childhood trauma associated with smaller hippocampal volume in women with major depression. Am J Psychiatry 159(12):2072–2080

    Article  PubMed  Google Scholar 

  • WHO (2004) International Statistical Classification of Diseases and Health Related Problems. World Health Organization, Geneva

    Google Scholar 

  • Wingo AP, Wrenn G, Pelletier T, Gutman AR, Bradley B, Ressler KJ (2010) Moderating effects of resilience on depression in individuals with a history of childhood abuse or trauma exposure. J Affect Disord 126(3):411–414

    Article  PubMed  Google Scholar 

  • Wolchik SA, Coxe S, Tein JY, Sandler IN, Ayers TS (2008) Six-year longitudinal predictors of posttraumatic growth in parentally bereaved adolescents and young adults. Omega (Westport) 58(2):107–128

    Article  Google Scholar 

  • Yu XN, Lau JT, Zhang J, Mak WW, Choi KC, Lui WW etal (2010) Posttraumatic growth and reduced suicidal ideation among adolescents at month 1 after the Sichuan earthquake. J Affect Disord 123(1–3):327–331

    Article  PubMed  Google Scholar 

  • Zeanah CH, Smyke AT, Koga SF, Carlson E (2005) Attachment in institutionalized and community children in Romania. Child Dev 76(5):1015–1028

    Article  PubMed  Google Scholar 

  • Zeanah CH, Egger HL, Smyke AT, Nelson CA, Fox NA, Marshall PJ etal (2009) Institutional rearing and psychiatric disorders in Romanian preschool children. Am J Psychiatry 166(7):777–785

    Article  PubMed  Google Scholar 

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Nater, U.M., Skoluda, N. (2013). Consequences of Developmental Stress in Humans: Adversity Experienced During Childhood and Adolescence. In: Laviola, G., Macrì, S. (eds) Adaptive and Maladaptive Aspects of Developmental Stress. Current Topics in Neurotoxicity, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5605-6_7

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