Abstract
Early life stress is a term used to describe adversities which may occur during childhood and adolescence. The majority of human studies focus on negative outcomes resulting from early life stress. There is an emerging research field which aims to investigate possible positive outcomes of early life stress. In this chapter, human studies are reviewed with regard to both maladaptive and adaptive consequences of early life stress. Recent findings suggest that early life stress is associated with central nervous alterations, altered physiological stress responses, impaired cognitive functioning as well as an increased risk of developing behavior problems, and somatic and psychiatric illnesses. Early life stress may also result in posttraumatic growth (PTG) which describes changes in self-perception, interpersonal relationships, and worldview. A psychobiological stress model is proposed to integrate the findings.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Alisic E, van der Schoot TA, van Ginkel JR, Kleber RJ (2008) Looking beyond posttraumatic stress disorder in children: posttraumatic stress reactions, posttraumatic growth, and quality of life in a general population sample. J Clin Psychiatry 69(9):1455–1461
APA (2000) Diagnostic statistical manual of mental disorders (Revised 4th edition). Author, Washington, DC
Barakat LP, Alderfer MA, Kazak AE (2006) Posttraumatic growth in adolescent survivors of cancer and their mothers and fathers. J Pediatr Psychol 31(4):413–419
Beach SR, Brody GH, Gunter TD, Packer H, Wernett P, Philibert RA (2010a) Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder. J Fam Psychol 24(1):12–20
Beach SR, Brody GH, Todorov AA, Gunter TD, Philibert RA (2010b) Methylation at SLC6A4 is linked to family history of child abuse: an examination of the Iowa adoptee sample. Am J Med Genet B Neuropsychiatr Genet 153B(2):710–713
Beach SR, Brody GH, Todorov AA, Gunter TD, Philibert RA (2011) Methylation at 5HTT mediates the impact of child sex abuse on women's antisocial behavior: an examination of the Iowa adoptee sample. Psychosom Med 73(1):83–87
Bernard K, Butzin-Dozier Z, Rittenhouse J, Dozier M (2010) Cortisol production patterns in young children living with birth parents vs children placed in foster care following involvement of Child Protective Services. Arch Pediatr Adolesc Med 164(5):438–443
Bet PM, Penninx BWJH, Bochdanovits Z, Uitterlinden AG, Beekman ATF, van Schoor NM etal (2009) Glucocorticoid receptor gene polymorphisms and childhood adversity are associated with depression: new evidence for a gene-environment interaction. Am J Med Genet B Neuropsychiatr Genet 150B(5):660–669
Binder EB, Bradley RG, Liu W, Epstein MP, Deveau TC, Mercer KB etal (2008) Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA 299(11):1291–1305
Bos KJ, Fox N, Zeanah CH, Nelson CA (2009) Effects of early psychosocial deprivation on the development of memory and executive function. Front Behav Neurosci 3:16
Bradley RG, Binder EB, Epstein MP, Tang Y, Nair HP, Liu W etal (2008) Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry 65(2):190–200
Bremner JD, Randall P, Scott TM, Capelli S, Delaney R, McCarthy G etal (1995) Deficits in short-term memory in adult survivors of childhood abuse. Psychiatry Res 59(1–2):97–107
Bremner JD, Narayan M, Staib LH, Southwick SM, McGlashan T, Charney DS (1999) Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder. Am J Psychiatry 156(11):1787–1795
Carpenter LL, Tyrka AR, Ross NS, Khoury L, Anderson GM, Price LH (2009) Effect of childhood emotional abuse and age on cortisol responsivity in adulthood. Biol Psychiatry 66(1):69–75
Carpenter LL, Gawuga CE, Tyrka AR, Lee JK, Anderson GM, Price LH (2010) Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults. Neuropsychopharmacology 35(13):2617–2623
Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW etal (2002) Role of genotype in the cycle of violence in maltreated children. Science 297(5582):851–854
Chandy JM, Blum RW, Resnick MD (1996) Gender-specific outcomes for sexually abused adolescents. Child Abuse Negl 20(12):1219–1231
Chisholm K (1998) A three year follow-up of attachment and indiscriminate friendliness in children adopted from Romanian orphanages. Child Dev 69(4):1092–1106
Chrousos GP (2009) Stress and disorders of the stress system. Nat Rev Endocrinol 5(7):374–381
Chugani HT, Behen ME, Muzik O, Juhasz C, Nagy F, Chugani DC (2001) Local brain functional activity following early deprivation: a study of postinstitutionalized Romanian orphans. Neuroimage 14(6):1290–1301
Cicchetti D, Rogosch FA (2001) Diverse patterns of neuroendocrine activity in maltreated children. Dev Psychopathol 13(3):677–693
Cirulli F, Francia N, Berry A, Aloe L, Alleva E, Suomi SJ (2009) Early life stress as a risk factor for mental health: role of neurotrophins from rodents to non-human primates. Neurosci Biobehav Rev 33(4):573–585
Cohen RA, Grieve S, Hoth KF, Paul RH, Sweet L, Tate D etal (2006) Early life stress and morphometry of the adult anterior cingulate cortex and caudate nuclei. Biol Psychiatry 59(10):975–982
Cryder CH, Kilmer RP, Tedeschi RG, Calhoun LG (2006) An exploratory study of posttraumatic growth in children following a natural disaster. Am J Orthopsychiatry 76(1):65–69
Danese A, Moffitt TE, Harrington H, Milne BJ, Polanczyk G, Pariante CM etal (2009) Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers. Arch Pediatr Adolesc Med 163(12):1135–1143
De Bellis MD, Hall J, Boring AM, Frustaci K, Moritz G (2001) A pilot longitudinal study of hippocampal volumes in pediatric maltreatment-related posttraumatic stress disorder. Biol Psychiatry 50(4):305–309
De Bellis MD, Keshavan MS, Shifflett H, Iyengar S, Beers SR, Hall J etal (2002) Brain structures in pediatric maltreatment-related posttraumatic stress disorder: a sociodemographically matched study. Biol Psychiatry 52(11):1066–1078
Devine KA, Reed-Knight B, Loiselle KA, Fenton N, Blount RL (2010) Posttraumatic growth in young adults who experienced serious childhood illness: a mixed-methods approach. J Clin Psychol Med Settings 17(4):340–348
Ditzen B, Nater UM, Heim C (2013) HPA axis challenge tests. In: Gellman MD, Turner JR (eds) Encyclopedia of behavioral medicine, Springer, Berlin pp. 1468–1471
Drury SS, Theall K, Gleason MM, Smyke AT, De Vivo I, Wong JY etal (2011) Telomere length and early severe social deprivation: linking early adversity and cellular aging. Mol Psychiatry 17(7):719–27
Dube SR, Anda RF, Felitti VJ, Chapman DP, Williamson DF, Giles WH (2001) Childhood abuse, household dysfunction, and the risk of attempted suicide throughout the life span: findings from the Adverse Childhood Experiences Study. JAMA 286(24):3089–3096
Dube SR, Fairweather D, Pearson WS, Felitti VJ, Anda RF, Croft JB (2009) Cumulative childhood stress and autoimmune diseases in adults. Psychosom Med 71(2):243–250
Elzinga BM, Schmahl CG, Vermetten E, van Dyck R, Bremner JD (2003) Higher cortisol levels following exposure to traumatic reminders in abuse-related PTSD. Neuropsychopharmacology 28(9):1656–1665
Elzinga BM, Roelofs K, Tollenaar MS, Bakvis P, van Pelt J, Spinhoven P (2008) Diminished cortisol responses to psychosocial stress associated with lifetime adverse events a study among healthy young subjects. Psychoneuroendocrinology 33(2):227–237
Feder A, Nestler EJ, Charney DS (2009) Psychobiology and molecular genetics of resilience. Nat Rev Neurosci 10(6):446–457
Flaherty EG, Thompson R, Litrownik AJ, Theodore A, English DJ, Black MM etal (2006) Effect of early childhood adversity on child health. Arch Pediatr Adolesc Med 160(12):1232–1238
Fujiwara T, Kawakami N, World Mental Health Japan Survey Group (2011) Association of childhood adversities with the first onset of mental disorders in Japan: results from the World Mental Health Japan, 2002–2004. J Psychiatr Res 45(4):481–487
Fuller-Thomson E, Brennenstuhl S, Frank J (2010) The association between childhood physical abuse and heart disease in adulthood: findings from a representative community sample. Child Abuse Negl 34(9):689–698
Furukawa T, Harai H, Hirai T, Fujihara S, Kitamura T, Takahashi K (1998) Childhood parental loss and alcohol dependence among Japanese men: a case–control study. Group for Longitudinal Affective Disorders Study (GLADS). Acta Psychiatr Scand 97(6):403–407
Gunnar MR, Morison SJ, Chisholm K, Schuder M (2001) Salivary cortisol levels in children adopted from Romanian orphanages. Dev Psychopathol 13(3):611–628
Gunstad J, Paul RH, Spitznagel MB, Cohen RA, Williams LM, Kohn M etal (2006) Exposure to early life trauma is associated with adult obesity. Psychiatry Res 142(1):31–37
Hafstad GS, Gil-Rivas V, Kilmer RP, Raeder S (2010) Parental adjustment, family functioning, and posttraumatic growth among Norwegian children and adolescents following a natural disaster. Am J Orthopsychiatry 80(2):248–257
Handa M, Nukina H, Hosoi M, Kubo C (2008) Childhood physical abuse in outpatients with psychosomatic symptoms. Biopsychosoc Med 2:8
Hanson JL, Chung MK, Avants BB, Shirtcliff EA, Gee JC, Davidson RJ etal (2010) Early stress is associated with alterations in the orbitofrontal cortex: a tensor-based morphometry investigation of brain structure and behavioral risk. J Neurosci 30(22):7466–7472
Heim C, Newport DJ, Heit S, Graham YP, Wilcox M, Bonsall R etal (2000) Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. JAMA 284(5):592–597
Heim C, Newport DJ, Bonsall R, Miller AH, Nemeroff CB (2001) Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse. Am J Psychiatry 158(4):575–581
Heim C, Newport DJ, Wagner D, Wilcox MM, Miller AH, Nemeroff CB (2002) The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis. Depress Anxiety 15(3):117–125
Heim C, Wagner D, Maloney E, Papanicolaou DA, Solomon L, Jones JF etal (2006) Early adverse experience and risk for chronic fatigue syndrome: results from a population-based study. Arch Gen Psychiatry 63(11):1258–1266
Heim C, Mletzko T, Purselle D, Musselman DL, Nemeroff CB (2008a) The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma. Biol Psychiatry 63(4):398–405
Heim C, Newport DJ, Mletzko T, Miller AH, Nemeroff CB (2008b) The link between childhood trauma and depression: insights from HPA axis studies in humans. Psychoneuroendocrinology 33(6):693–710
Heim C, Bradley B, Mletzko TC, Deveau TC, Musselman DL, Nemeroff CB etal (2009a) Effect of childhood trauma on adult depression and neuroendocrine function: sex-specific moderation by CRH receptor 1 gene. Front Behav Neurosci 3:41
Heim C, Nater UM, Maloney E, Boneva R, Jones JF, Reeves WC (2009b) Childhood trauma and risk for chronic fatigue syndrome: association with neuroendocrine dysfunction. Arch Gen Psychiatry 66(1):72–80
Heim C, Young LJ, Newport DJ, Mletzko T, Miller AH, Nemeroff CB (2009c) Lower CSF oxytocin concentrations in women with a history of childhood abuse. Mol Psychiatry 14(10):954–958
Ho SM, Chu KW, Yiu J (2008) The relationship between explanatory style and posttraumatic growth after bereavement in a non-clinical sample. Death Stud 32(5):461–478
Huey SJ Jr, Weisz JR (1997) Ego control, ego resiliency, and the five-factor model as predictors of behavioral and emotional problems in clinic-referred children and adolescents. J Abnorm Psychol 106(3):404–415
Johnson JG, Cohen P, Brown J, Smailes EM, Bernstein DP (1999) Childhood maltreatment increases risk for personality disorders during early adulthood. Arch Gen Psychiatry 56(7):600–606
Jouriles EN, Barling J, Oleary KD (1987) Predicting child-behavior problems in maritally violent families. J Abnorm Child Psychol 15(2):165–173
Kamibeppu K, Sato I, Honda M, Ozono S, Sakamoto N, Iwai T etal (2010) Mental health among young adult survivors of childhood cancer and their siblings including posttraumatic growth. J Cancer Surviv 4(4):303–312
Kananen L, Surakka I, Pirkola S, Suvisaari J, Lonnqvist J, Peltonen L etal (2010) Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls. PLoS One 5(5):e10826
Kaufman J, Birmaher B, Perel J, Dahl RE, Moreci P, Nelson B etal (1997) The corticotropin-releasing hormone challenge in depressed abused, depressed nonabused, and normal control children. Biol Psychiatry 42(8):669–679
Kendler KS, Bulik CM, Silberg J, Hettema JM, Myers J, Prescott CA (2000) Childhood sexual abuse and adult psychiatric and substance use disorders in women: an epidemiological and cotwin control analysis. Arch Gen Psychiatry 57(10):953–959
Kendler KS, Kuhn JW, Prescott CA (2004) Childhood sexual abuse, stressful life events and risk for major depression in women. Psychol Med 34(8):1475–1482
Kiecolt-Glaser JK, Gouin JP, Weng NP, Malarkey WB, Beversdorf DQ, Glaser R (2011) Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation. Psychosom Med 73(1):16–22
Kilmer RP, Gil-Rivas V (2010) Exploring posttraumatic growth in children impacted by Hurricane Katrina: correlates of the phenomenon and developmental considerations. Child Dev 81(4):1211–1227
Kilmer RP, Gil-Rivas V, Tedeschi RG, Cann A, Calhoun LG, Buchanan T etal (2009) Use of the revised posttraumatic growth inventory for children. J Trauma Stress 22(3):248–253
Kim J, Cicchetti D, Rogosch FA, Manly JT (2009) Child maltreatment and trajectories of personality and behavioral functioning: implications for the development of personality disorder. Dev Psychopathol 21(3):889–912
King JA, Mandansky D, King S, Fletcher KE, Brewer J (2001) Early sexual abuse and low cortisol. Psychiatry Clin Neurosci 55(1):71–74
Klaassens ER, van Noorden MS, Giltay EJ, van Pelt J, van Veen T, Zitman FG (2009) Effects of childhood trauma on HPA-axis reactivity in women free of lifetime psychopathology. Prog Neuropsychopharmacol Biol Psychiatry 33(5):889–894
Kudielka BM, Wust S (2010) Human models in acute and chronic stress: assessing determinants of individual hypothalamus-pituitary-adrenal axis activity and reactivity. Stress 13(1):1–14
Kunugi H, Sugawara N, Aoki H, Nanko S, Hirose T, Kazamatsuri H (1995) Early parental loss and depressive disorder in Japan. Eur Arch Psychiatry Clin Neurosci 245(2):109–113
Lampe A, Doering S, Rumpold G, Solder E, Krismer M, Kantner-Rumplmair W etal (2003) Chronic pain syndromes and their relation to childhood abuse and stressful life events. J Psychosom Res 54(4):361–367
Lanier P, Jonson-Reid M, Stahlschmidt MJ, Drake B, Constantino J (2010) Child maltreatment and pediatric health outcomes: a longitudinal study of low-income children. J Pediatr Psychol 35(5):511–522
Lansford JE, Miller-Johnson S, Berlin LJ, Dodge KA, Bates JE, Pettit GS (2007) Early physical abuse and later violent delinquency: a prospective longitudinal study. Child Maltreat 12(3):233–245
Laufer A, Solomon Z, Levine SZ (2010) Elaboration on posttraumatic growth in youth exposed to terror: the role of religiosity and political ideology. Soc Psychiatry Psychiatr Epidemiol 45(6):647–653
Letzring TD, Block J, Funder DC (2005) Ego-control and ego-resiliency: generalization of self-report scales based on personality descriptions from acquaintances, clinicians, and the self. J Res Pers 39(4):395–422
Levine SZ, Laufer A, Hamama-Raz Y, Stein E, Solomon Z (2008) Posttraumatic growth in adolescence: examining its components and relationship with PTSD. J Trauma Stress 21(5):492–496
Levine SZ, Laufer A, Stein E, Hamama-Raz Y, Solomon Z (2009) Examining the relationship between resilience and posttraumatic growth. J Trauma Stress 22(4):282–286
Lovallo WR, Farag NH, Sorocco KH, Cohoon AJ, Vincent AS (2012) Lifetime adversity leads to blunted stress axis reactivity: studies from the oklahoma family health patterns project. Biol Psychiatry 71(4):344–349
Luecken LJ (1998) Childhood attachment and loss experiences affect adult cardiovascular and cortisol function. Psychosom Med 60(6):765–772
MacMillan HL, Georgiades K, Duku EK, Shea A, Steiner M, Niec A etal (2009) Cortisol response to stress in female youths exposed to childhood maltreatment: results of the youth mood project. Biol Psychiatry 66(1):62–68
Maikovich-Fong AK, Jaffee SR (2010) Sex differences in childhood sexual abuse characteristics and victims' emotional and behavioral problems: findings from a national sample of youth. Child Abuse Negl 34(6):429–437
Majer M, Nater UM, Lin JM, Capuron L, Reeves WC (2010) Association of childhood trauma with cognitive function in healthy adults: a pilot study. BMC Neurol 10:61
McEwen BS, Seeman T (1999) Protective and damaging effects of mediators of stress. Elaborating and testing the concepts of allostasis and allostatic load. Ann N Y Acad Sci 896:30–47
Meinlschmidt G, Heim C (2005) Decreased cortisol awakening response after early loss experience. Psychoneuroendocrinology 30(6):568–576
Meyerson DA, Grant KE, Carter JS, Kilmer RP (2011) Posttraumatic growth among children and adolescents: a systematic review. Clin Psychol Rev 31(6):949–964
Mills R, Alati R, O'Callaghan M, Najman JM, Williams GM, Bor W etal (2011) Child abuse and neglect and cognitive function at 14 years of age: findings from a birth cohort. Pediatrics 127(1):4–10
Moran P, Coffey C, Chanen A, Mann A, Carlin JB, Patton GC (2011) Childhood sexual abuse and abnormal personality: a population-based study. Psychol Med 41(06):1311–1318
Morina N, von Lersner U, Prigerson HG (2011) War and bereavement: consequences for mental and physical distress. PLoS One 6(7):e22140
Navalta CP, Polcari A, Webster DM, Boghossian A, Teicher MH (2006) Effects of childhood sexual abuse on neuropsychological and cognitive function in college women. J Neuropsychiatry Clin Neurosci 18(1):45–53
Nelson EC, Heath AC, Madden PA, Cooper ML, Dinwiddie SH, Bucholz KK etal (2002) Association between self-reported childhood sexual abuse and adverse psychosocial outcomes: results from a twin study. Arch Gen Psychiatry 59(2):139–145
Nelson CA, Zeanah CH, Fox NA, Marshall PJ, Smyke AT, Guthrie D (2007) Cognitive recovery in socially deprived young children: the Bucharest Early Intervention Project. Science 318(5858):1937–1940
Newport DJ, Heim C, Bonsall R, Miller AH, Nemeroff CB (2004) Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse. Biol Psychiatry 55(1):10–20
Nicolson NA, Davis MC, Kruszewski D, Zautra AJ (2010) Childhood maltreatment and diurnal cortisol patterns in women with chronic pain. Psychosom Med 72(5):471–480
O'Donovan A, Epel E, Lin J, Wolkowitz O, Cohen B, Maguen S etal (2011) Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder. Biol Psychiatry 70(5):465–71
O'Mahony SM, Marchesi JR, Scully P, Codling C, Ceolho AM, Quigley EM etal (2009) Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses. Biol Psychiatry 65(3):263–267
Opacka-Juffry J, Mohiyeddini C (2011) Experience of stress in childhood negatively correlates with plasma oxytocin concentration in adult men. Stress 15(1):1–10
Ozbay F, Johnson DC, Dimoulas E, Morgan CA, Charney D, Southwick S (2007) Social support and resilience to stress: from neurobiology to clinical practice. Psychiatry (Edgmont) 4(5):35–40
Patton GC, Coffey C, Posterino M, Carlin JB, Bowes G (2003) Life events and early onset depression: cause or consequence? Psychol Med 33(7):1203–1210
Pollak SD, Nelson CA, Schlaak MF, Roeber BJ, Wewerka SS, Wiik KL etal (2010) Neurodevelopmental effects of early deprivation in postinstitutionalized children. Child Dev 81(1):224–236
Rao U, Hammen C, Ortiz LR, Chen LA, Poland RE (2008) Effects of early and recent adverse experiences on adrenal response to psychosocial stress in depressed adolescents. Biol Psychiatry 64(6):521–526
Romans S, Belaise C, Martin J, Morris E, Raffi A (2002) Childhood abuse and later medical disorders in women. An epidemiological study. Psychother Psychosom 71(3):141–150
Salter E, Stallard P (2004) Posttraumatic growth in child survivors of a road traffic accident. J Trauma Stress 17(4):335–340
Schilling EA, Aseltine RH Jr, Gore S (2007) Adverse childhood experiences and mental health in young adults: a longitudinal survey. BMC Public Health 7:30
Schmidt MV, Wang XD, Meijer OC (2011) Early life stress paradigms in rodents: potential animal models of depression? Psychopharmacology (Berl) 214(1):131–140
Shakespeare-Finch J, de Dassel T (2009) Exploring posttraumatic outcomes as a function of childhood sexual abuse. J Child Sex Abus 18(6):623–640
Silberg J, Rutter M, Neale M, Eaves L (2001) Genetic moderation of environmental risk for depression and anxiety in adolescent girls. Br J Psychiatry 179:116–121
Silverman AB, Reinherz HZ, Giaconia RM (1996) The long-term sequelae of child and adolescent abuse: a longitudinal community study. Child Abuse Negl 20(8):709–723
Stein MB, Koverola C, Hanna C, Torchia MG, McClarty B (1997) Hippocampal volume in women victimized by childhood sexual abuse. Psychol Med 27(4):951–959
Tedeschi RG, Calhoun LG (1996) The Posttraumatic Growth Inventory: measuring the positive legacy of trauma. J Trauma Stress 9(3):455–471
Teicher MH, Dumont NL, Ito Y, Vaituzis C, Giedd JN, Andersen SL (2004) Childhood neglect is associated with reduced corpus callosum area. Biol Psychiatry 56(2):80–85
Thompson R, Tabone JK (2010) The impact of early alleged maltreatment on behavioral trajectories. Child Abuse Negl 34(12):907–916
Thornberry TP, Henry KL, Ireland TO, Smith CA (2010) The causal impact of childhood-limited maltreatment and adolescent maltreatment on early adult adjustment. J Adolesc Health 46(4):359–365
Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR etal (2010) Childhood maltreatment and migraine (part III). Association with comorbid pain conditions. Headache 50(1):42–51
Turner-Sack AM, Menna R, Setchell SR (2012) Posttraumatic growth, coping strategies, and psychological distress in adolescent survivors of cancer. J Pediatr Oncol Nurs 29(2):70–79
Tyrka AR, Wier L, Price LH, Ross N, Anderson GM, Wilkinson CW etal (2008) Childhood parental loss and adult hypothalamic-pituitary-adrenal function. Biol Psychiatry 63(12):1147–1154
Tyrka AR, Wyche MC, Kelly MM, Price LH, Carpenter LL (2009) Childhood maltreatment and adult personality disorder symptoms: influence of maltreatment type. Psychiatry Res 165(3):281–287
Tyrka AR, Price LH, Kao HT, Porton B, Marsella SA, Carpenter LL (2010) Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging. Biol Psychiatry 67(6):531–534
van der Vegt EJ, van der Ende J, Kirschbaum C, Verhulst FC, Tiemeier H (2009) Early neglect and abuse predict diurnal cortisol patterns in adults A study of international adoptees. Psychoneuroendocrinology 34(5):660–669
van der Vegt EJ, van der Ende J, Huizink AC, Verhulst FC, Tiemeier H (2010) Childhood adversity modifies the relationship between anxiety disorders and cortisol secretion. Biol Psychiatry 68(11):1048–1054
Vythilingam M, Heim C, Newport J, Miller AH, Anderson E, Bronen R etal (2002) Childhood trauma associated with smaller hippocampal volume in women with major depression. Am J Psychiatry 159(12):2072–2080
WHO (2004) International Statistical Classification of Diseases and Health Related Problems. World Health Organization, Geneva
Wingo AP, Wrenn G, Pelletier T, Gutman AR, Bradley B, Ressler KJ (2010) Moderating effects of resilience on depression in individuals with a history of childhood abuse or trauma exposure. J Affect Disord 126(3):411–414
Wolchik SA, Coxe S, Tein JY, Sandler IN, Ayers TS (2008) Six-year longitudinal predictors of posttraumatic growth in parentally bereaved adolescents and young adults. Omega (Westport) 58(2):107–128
Yu XN, Lau JT, Zhang J, Mak WW, Choi KC, Lui WW etal (2010) Posttraumatic growth and reduced suicidal ideation among adolescents at month 1 after the Sichuan earthquake. J Affect Disord 123(1–3):327–331
Zeanah CH, Smyke AT, Koga SF, Carlson E (2005) Attachment in institutionalized and community children in Romania. Child Dev 76(5):1015–1028
Zeanah CH, Egger HL, Smyke AT, Nelson CA, Fox NA, Marshall PJ etal (2009) Institutional rearing and psychiatric disorders in Romanian preschool children. Am J Psychiatry 166(7):777–785
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media New York
About this chapter
Cite this chapter
Nater, U.M., Skoluda, N. (2013). Consequences of Developmental Stress in Humans: Adversity Experienced During Childhood and Adolescence. In: Laviola, G., Macrì, S. (eds) Adaptive and Maladaptive Aspects of Developmental Stress. Current Topics in Neurotoxicity, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5605-6_7
Download citation
DOI: https://doi.org/10.1007/978-1-4614-5605-6_7
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-5604-9
Online ISBN: 978-1-4614-5605-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)