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Tumor Oxygen Measurements and Personalized Medicine

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Oxygen Transport to Tissue XXXIV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 765))

Abstract

Tumor hypoxia is probably the most important not yet measurable factor that predicts the outcome of cancer therapy. Hypoxic tumors are resistant to radiation, chemotherapy, and surgery. They signal tumor cells to grow, invade, survive cytotoxic-factor assault, and increase metastatic activity. Therapies aimed at reversing hypoxia-related treatment resistance or normalizing hypoxia are proven effective with level 1 evidence. The weak link remains the lack of satisfactory methods of measurement of tumor oxygenation.

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Acknowledgments

We thank Kate Casey-Sawicki for editing and preparing this manuscript for publication.

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, University of Florida, 103633, Gainesville, FL, 32610, USA

    Paul Okunieff, Walter O’Dell, Mei Zhang, Lurong Zhang & David Maguire

Authors
  1. Paul Okunieff
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  2. Walter O’Dell
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  3. Mei Zhang
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  4. Lurong Zhang
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  5. David Maguire
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Corresponding author

Correspondence to Paul Okunieff .

Editor information

Editors and Affiliations

  1. Division of Nephrology and Hypertension, Georgetown University, Washington, DC, USA

    William J. Welch

  2. Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

    Fredrik Palm

  3. Synthesizer, Inc., Ellicott City, MD, USA

    Duane F. Bruley

  4. Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK

    David K. Harrison

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Okunieff, P., O’Dell, W., Zhang, M., Zhang, L., Maguire, D. (2013). Tumor Oxygen Measurements and Personalized Medicine. In: Welch, W.J., Palm, F., Bruley, D.F., Harrison, D.K. (eds) Oxygen Transport to Tissue XXXIV. Advances in Experimental Medicine and Biology, vol 765. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4989-8_27

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