Abstract
For at least three decades (1–6) there has been an interest in measuring tumor blood flow (TBF) and in the determination of its relation to the response of human tumors to radiation, drug therapies, and to the probability of development of distant metastases. The proton activation method which will be described below allows daily measurements of blood flow, in only 7 minutes, in patients being irradiated by photons of ≥20 MV, or by protons and other heavy particles.
This work supported in part by NIH grants CA48096, RR00995, and CA13311, and by the American Cancer Society Career Development Award.
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Okunieff, P., Lee, J., Vaupel, P. (1992). Measurement of Human Tumor Blood Flow: A Positron Technique Using an Artifact of High Energy Radiation Therapy. In: Erdmann, W., Bruley, D.F. (eds) Oxygen Transport to Tissue XIV. Advances in Experimental Medicine and Biology, vol 317. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3428-0_17
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