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Skin and Transdermal Drug Delivery

Advantages and Challenges

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Microdialysis in Drug Development

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 4))

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Abstract

This chapter will give a review of microdialysis sampling in the skin with emphasis on dermal sampling and topical application of drugs and other substances in the form of transdermal patches, solutions, or topical formulations. Microdialysis as a research technique is suitable for a number of different study designs for sampling in the skin or subcutaneous tissues. This versatility includes the option of preclinical studies in animals as well as ex vivo human skin set ups. Alterations in the barrier properties of the skin, introduced intentionally or associated with skin diseases, will alter the penetration of drugs and other substances considerably. Furthermore, the effect of even small alterations in a topical formulation can be detected by simultaneous sampling in several areas in the same individual, enabling studies of bioavailability and bioequivalence in study groups of relatively few volunteers or patients. Whenever the dermis is the target tissue, dermal microdialysis can be considered to be the method of choice for acquisition of human in vivo data. The current status with regulatory authorities as well as the study planning for successful sampling will be described.

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Authors and Affiliations

  1. Department of Dermatology, Faculty of Health Sciences, University of Copenhagen, Roskilde Hospital, Koegevej 7-13, DK 4000, Roskilde, Denmark

    Eva Benfeldt

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  1. Eva Benfeldt
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Correspondence to Eva Benfeldt .

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  1. Allgemeines Krankenhaus, Department of Clinical Pharmacology, Medical University Vienna, Währinger Gürtel 18-20, Vienna, 1090, Austria

    Markus Müller

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Benfeldt, E. (2013). Skin and Transdermal Drug Delivery. In: Müller, M. (eds) Microdialysis in Drug Development. AAPS Advances in the Pharmaceutical Sciences Series, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4815-0_7

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