Abstract
Laryngopharyngeal reflux (LPR) occurs when gastric contents pass through the upper esophageal sphincter (UES) into the upper aerodigestive tract (UADT). These relatively brief episodes can have sinister implications, resulting in irritation to the delicate mucosa of the larynx, pharynx, Eustachian tubes, and nasal passages. The subsequent inflammatory changes that take place are responsible for many of the signs and symptoms that have come to define the disease process. The majority of patients with LPR lack the classic gastroesophageal reflux (GER) symptoms of heartburn, and dysphagia, therefore making the diagnosis more challenging (Koufman, Laryngoscope, 101:1–78, 1991). Instead, patients with LPR commonly present with a constellation of symptoms reflective of UADT inflammation including chronic cough, hoarseness, and postnasal drip (Fennerty, Gastroenterol Clin North Am, 28:861–873, 1990; Koufman, Gastroesophageal reflux and voice disorders. In: Rubin J (ed) Diagnosis and treatment of voice disorders. Igaku-Shoin, New York, pp 161–175, 1995). Unfortunately, the relative ubiquity of these nonspecific symptoms makes the diagnosis of LPR difficult to establish based solely on clinical presentation. In turn, further workup is often necessary, requiring a combination of laryngoscopy (Fennerty, Gastroenterol Clin North Am, 28:861–873, 1990; Maronian et al., Laaryngology, 110:606–612, 2001), dualprobe pH monitoring (Muderris et al., Arch Otolaryngol Head Neck Surg, 135:163–167, 2009), and multichannel intraluminal impedance (MCII) testing (Kawamura et al., Am J Gastroenterol, 99:1000–1010, 2004; Hoppo et al., J Gastrointest Surg, 16:16–25, 2012). While each of these tests provides important diagnostic data, they are not without shortcomings. In fact, an accurate diagnostic tool for LPR has yet to be identified, and clearly defined diagnostic criteria have yet to be agreed upon. While the workup of LPR remains controversial, the treatment is more widely accepted and employs a combination of behavioral changes and medical management including PPIs, H2 blockers, mucosal cryoprotectants, and prokinetic agents. Response to therapy is often variable, and many patients require aggressive antiacid intervention to have complete resolution of symptoms (Vaezi, Nat Clin Pract Gastroenterol Hepatol 2:595–603, 2005). Despite these aggressive approaches, there are subsets of patients deemed refractory to medical management. In these cases, surgical intervention may be needed to achieve complete or even partial resolution of symptoms (Oelschlager et al., Gastrointest Surg, 6:189–194, 2002; Brown et al., Surg Endosc, 25:3852–3858, 2011).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Koufman J. The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope. 1991;101:1–78.
Fennerty MB. Extraesophageal gastroesophageal reflux disease: presentations and approach to treatment. Gastroenterol Clin North Am. 1990;28:861–73.
Koufman J. Gastroesophageal reflux and voice disorders. In: Rubin J, editor. Diagnosis and treatment of voice disorders. New York: Igaku-Shoin; 1995. p. 161–75.
Maronian N, Azadeh H, Waugh P, Hillel A. Association of laryngopharyngeal reflux disease and subglottic stenosis. Ann Otol Rhinol Laryngol. 2001;110:606–12.
Muderris T, Gokcan M, Yorulmaz I. The clinical value of pharyngeal ph monitoring using a double-probe, triple-sensor catheter in patients with laryngopharyngeal reflux. Arch Otolaryngol Head Neck Surg. 2009;135:163–7.
Kawamura O, Aslam M, Rittmann T, Hofmann C, Shaker R. Physical and pH properties of gastroesophagopharyngeal refluxate: a 24-hour simultaneous ambulatory impedance and pH monitoring study. Am J Gastroenterol. 2004;99:1000–10.
Hoppo T, Sanz A, Nason K, et al. How much pharyngeal exposure is‚ ÄúNormal‚Äù? Normative data for laryngopharyngeal reflux events using Hypopharyngeal Multichannel Intraluminal Impedance (HMII). J Gastrointest Surg. 2012;16:16–25.
Vaezi MF. Therapy insight: gastroesophageal reflux disease and laryngopharyngeal reflux. Nat Clin Pract Gastroenterol Hepatol. 2005;2:595–603.
Oelschlager BK, Eubanks TR, Maronian N, et al. Laryngoscopy and pharyngeal pH are complementary in the diagnosis of gastroesophageal-laryngeal reflux. J Gastrointest Surg. 2002;6:189–94.
Brown S, Gyawali CP, Melman L, et al. Clinical outcomes of atypical extra-esophageal reflux symptoms following laparoscopic antireflux surgery. Surg Endosc. 2011;25:3852–8.
Celik M, Alkan Z, Ercan I, et al. Cricopharyngeal muscle electromyography in laryngopharyngeal reflux. Laryngoscope. 2005;115:138–42.
Rolla G, Colagrande P, Magnano M, et al. Extrathoracic airway dysfunction in cough associated with gastroesophageal reflux. J Allergy Clin Immunol. 1998;102:204–9.
Patti M, Debas H, Pellegrini CA. Clinical and functional characterization of high gastroesophageal reflux. Am J Surg. 1993;165:163–8.
Diener U, Patti MG, Molena D, Fisichella PM, Way LW. Esophageal dysmotility and gastroesophageal reflux disease. J Gastrointest Surg. 2001;5:260–5.
Postma G, Tomek M, Belafsky P, Koufman J. Esophageal motor function in laryngopharyngeal reflux is superior to that in classic gastroesophageal reflux disease. Ann Otol Rhinol Laryngol. 2001;110:1114–6.
Knight RE, Wells JR, Parrish RS. Esophageal dysmotility as an important co-factor in extraesophageal manifestations of gastroesophageal reflux. Laryngoscope. 2000;110:1462–6.
Axford S, Sharp N, Ross P, et al. Cell biology of laryngeal epithelial defenses in health and disease: preliminary studies. Ann Otol Rhinol Laryngol. 2001;110:1099–108.
Johnston N, Bulmer D, Gill G, et al. Cell biology of laryngeal epithelial defenses in health and disease: further studies. Ann Otol Rhinol Laryngol. 2003;112:481–91.
Yitlalo R, Thibeault S. Relationship between time of exposure of laryngopharyngeal reflux and gene expression in laryngeal fibroblasts. Ann Otol Rhinol Laryngol. 2006;115:775–83.
Lang IM, Haworth ST, Medda BK, Roerig DL, Forster HV, Shaker R. Airway responses to esophageal acidification. Am J Physiol Regul Integr Comp Physiol. 2008;294:R211–9.
Gallelli L, D’Agostino B, Marrocco G, et al. Role of tachykinins in the bronchoconstriction induced by HCl intraesophageal instillation in the rabbit. Life Sci. 2003;72:1135–42.
Wong IWY, Rees G, Greiff L, Myers JC, Jamieson GG, Wormald P-J. Gastroesophageal reflux disease and chronic sinusitis: in search of an esophageal-nasal reflex. Am J Rhinol Allergy. 2010;24:255–9.
Gallup Organization. Heartburn across America: a Gallup Organization National Survey. Princeton: Gallup Organization; 1988.
Book DT, Rhee JS, Toohill RJ, Smith TL. Perspectives in laryngopharyngeal reflux: an international survey. Laryngoscope. 2002;112:1399–406.
Vakil N, Van Zanten SV, Kahrilas P, Dent J, Jones R. The montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101:1900–20.
Irwin R, Furley F, French C. Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy. Am Rev Respir Dis. 1990;141:640–7.
Thomas J, Zubiaur F. Over-diagnosis of laryngopharyngeal reflux as the cause of hoarseness. Eur Arch Otorhinolaryngol. 2013;270:995–9.
Hopkins C, Umbreen Y, Pedersen M. Acid reflux treatment for hoarseness. Cochrane Database Syst Rev. 2006;25.
Jacob P, Kahrilas P, Herzon G. Proximal esophageal pH-metry in patients with ‘reflux laryngitis’. Gastroenterology. 1991;100:305–10.
Koufman J, Amin M, Panetti M. Prevalence of reflux in 113 consecutive patients with laryngeal and voice disorders. Otolaryngol Head Neck Surg. 2000;123:385–8.
Park KH, Choi SM, Kwon SU, Yoon SW, Kim SU. Diagnosis of laryngopharyngeal reflux among Globus patients. Otolaryngol Head Neck Surg. 2006;134:81–5.
Chodosh P. Gastro-esophago-pharyngeal reflux. Laryngoscope. 1977;87:1418–27.
Loughlin C, Koufman J. Paroxysmal laryngospasm secondary to gastroesophageal reflux. Laryngoscope. 1996;106:1502–5.
Heller A, Wohl D. Vocal fold granuloma induced by rigid bronchoscopy. Ear Nose Throat J. 1999;78:176–8.
Svensson G, Schalen L, Rex S. Pathogenesis of idiopathic contact granuloma of the larynx: results of a prospective clinical study. Acta Otolaryngol Suppl. 1988;449:123–5.
Gabriel C, Jones D. The importance of chronic laryngitis. J Laryngol Otol. 1960;74:349–57.
Tae K, Jin BJ, Ji YB, Jeong JH, Cho SH, Lee SH. The role of laryngopharyngeal reflux as a risk factor in laryngeal cancer: a preliminary report. Clin Exp Otorhinolaryngol. 2011;4:101–4.
Flook E, Kumar B. Is there evidence to link acid reflux with chronic sinusitis or any nasal symptoms? A review of the evidence. Rhinology. 2011;49:11–6.
Phipps CD, Wood WE, Gibson WS, Cochran WJ. Gastroesophageal reflux contributing to chronic sinus disease in children: a prospective analysis. Arch Otolaryngol Head Neck Surg. 2000;126:831–6.
DelGaudio JM. Direct nasopharyngeal reflux of gastric acid is a contributing factor in refractory chronic rhinosinusitis. Laryngoscope. 2005;115:946–57.
Wong IWY, Omari TI, Myers JC, et al. Nasopharyngeal pH monitoring in chronic sinusitis patients using a novel four channel probe. Laryngoscope. 2004;114:1582–5.
Pincus R, Kim H, Silvers S, Gold S. A study of the link between gastric reflux and chronic sinusitis in adults. Ear Nose Throat J. 2006;85:174–8.
Heavner SB, Hardy SM, White DR, McQueen CT, Prazma J, Pillsbury HC. Function of the Eustachian tube after weekly exposure to pepsin/hydrochloric acid. Otolaryngol Head Neck Surg. 2001;125:123–9.
Velepic M, Rozmanic V, Velepic M, Bonifacic M. Gastroesophageal reflux, allergy and chronic tubotympanal disorders in children. Int J Pediatr Otorhinolaryngol. 2000;55:187–90.
Rozmanic V, Velepic M, Ahel V, Bonifacic D, Velepic M. Prolonged esophageal pH monitoring in the evaluation of gastroesophageal reflux in children with chronic tubotympanal disorders. J Pediatr Gastroenterol Nutr. 2002;34:278–80.
Keles B, Ozturk K, Gunel E, Arbag H, Ozer B. Pharyngeal reflux in children with chronic otitis media with effusion. Acta Otolaryngol. 2004;124:1178–781.
Al-Saab F, Manoukian J, Al-Sabah B, et al. Linking laryngopharyngeal reflux to otitis media with effusion: pepsinogen study of adenoid tissue and middle ear fluid. J Otolaryngol Head Neck Surg. 2008;37:565–71.
Tasker A, Dettmar PW, Panetti M, Koufman JA, P Birchall J, Pearson JP. Is gastric reflux a cause of otitis media with effusion in children? Laryngoscope. 2002;112:1930–4.
Poelmans J, Tack J, Feenstra L. Chronic middle ear disease and gastroesophageal reflux disease: a causal relation? Otol Neurotol. 2001;22:447–50.
Miura MS, Mascaro M, Rosenfeld RM. Association between otitis media and gastroesophageal reflux: a systematic review. Otolaryngol Head Neck Surg. 2011;146(3):345–52.
Ardehali J, Seraj M, Asiabar H. The possible role of gastroesophageal reflux disease in children suffering from chronic otitis media with effusion. Acta Med Iran. 2008;46:33–7.
Koufman J. Laryngopharyngeal reflux is different from classic gastroesophageal reflux disease. Ear Nose Throat J. 2002;81:7–9.
Kahrilas PJ, Shaheen NJ, Vaezi MF. American Gastroenterological Association medical position statement on the management of gastroesophageal reflux disease. Gastroenterology. 2008;135:1383–1391.e1385.
Ayazi S, Lipham JC, Hagen JA, et al. A new technique for measurement of pharyngeal pH: normal values and discriminating pH threshold. J Gastrointest Surg. 2009;13:1422–9.
Hicks D, Ours TM, Abelson T, Vaezi M, Richter J. The prevalence of hypopharynx findings associated with gastroesophageal reflux in normal volunteers. J Voice. 2002;16:564–79.
Belafsky P, Postma G, Koufam J. Validity and reliability of the reflux symptom index (RSI). J Voice. 2002;16:274–7.
Ylitalo R, Lindestad P-Å, Ramel S. Symptoms, laryngeal findings, and 24-hour pH monitoring in patients with suspected gastroesophago-pharyngeal reflux. Laryngoscope. 2001;111:1735–41.
Belafsky PC, Postma GN, Koufman JA. The validity and reliability of the Reflux Finding Score (RFS). Laryngoscope. 2001;111:1313–7.
Kelchner LN, Horne J, Lee L, et al. Reliability of speech-language pathologist and otolaryngologist ratings of laryngeal signs of reflux in an asymptomatic population using the reflux finding score. J Voice. 2007;21:92–100.
Milstein C, Charbel S, Hicks D, Abelson T, Richter J, Vaezi M. Prevalence of laryngeal irritation signs associated with reflux in asymptomatic volunteers: impact of endoscopic technique (rigid vs. flexible laryngoscope). Laryngoscope. 2005;115:2256–61.
Ford C. Evaluation and management of laryngopharyngeal reflux. JAMA. 2005;294:1534–40.
Vaezi M, Schroeder P, Richter J. Reproducibility of proximal probe pH parameters in 24-hour ambulatory esophageal pH monitoring. Am J Gastroenterol. 1997;92:825–9.
Harrell SP, Koopman J, Woosley S, Wo JM. Exclusion of pH artifacts is essential for hypopharyngeal pH monitoring. Laryngoscope. 2007;117:470–4.
Richardson B, Heywood B, Sims H, Stoner J, Leopold D. Laryngopharyngeal reflux: trends in diagnostic interpretation criteria. Dysphagia. 2004;19:248–55.
Ludemann J, Manoukian J, Shaw K, Bernard C, Davis M, Al-Jubab A. Effects of simulated gastroesophageal reflux on the untraumatized rabbit larynx. J Otolaryngol. 1988;27:127–31.
Oelschlager BK, Eubanks TR, Oleynikov D, Pope C, Pellegrini CA. Symptomatic and physiologic outcomes after operative treatment for extraesophageal reflux. Surg Endosc Other Interv Techn. 2002;16:1032–6.
Francis DO, Goutte M, Slaughter JC, et al. Traditional reflux parameters and not impedance monitoring predict outcome after fundoplication in extraesophageal reflux. Laryngoscope. 2011;121:1902–9.
Kamel P, Hanson D, Kahrillas P. Omeprazole for the treatment of posterior laryngitis. Am J Med. 1994;96:321–6.
Shaw G, Searl J. Laryngeal manifestations of GER before and after treatment with omeprazole. South Med J. 1997;1997:1115–22.
Wo J, Grist W, G Gussack JD, Warning J. Empiric trial of high-dose omeprazole in patients with posterior laryngitis (a prospective study). Am J Gastroenterol. 1997;92:210–2165.
Vaezi M, Hicks D, Ours TM, Richter J. ENT manifestations of GERD (a large prospective study assessing treatment outcome and predictors of response). Gastroenterology. 2001;2001:A636.
Patti MG, Arcerito M, Tamburini A, et al. Effect of laparoscopic fundoplication on gastroesophageal reflux disease-induced respiratory symptoms. J Gastrointest Surg. 2000;4:143–9.
Kaufman JA, Houghland JE, Quiroga E, Cahill M, Pelligrini CA, Oelschlager BK. Long-term outcomes of laparoscopic antireflux surgery for gastroesophageal reflux disease (GERD)-related airway disorder. Surg Endosc. 2006;20:1824–30.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag London
About this chapter
Cite this chapter
Walker, D.D., Langerman, A.J. (2014). Head and Neck Manifestations of Gastroesophageal Reflux Disease. In: Fisichella, P., Soper, N., Pellegrini, C., Patti, M. (eds) Surgical Management of Benign Esophageal Disorders. Springer, London. https://doi.org/10.1007/978-1-4471-5484-6_7
Download citation
DOI: https://doi.org/10.1007/978-1-4471-5484-6_7
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-4471-5483-9
Online ISBN: 978-1-4471-5484-6
eBook Packages: MedicineMedicine (R0)