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Updating an Overview of Teratology

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Teratogenicity Testing

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2753))

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Abstract

In this chapter, the authors aim to update an overview of the principles of teratology, beginning with the definition of teratology, the critical point at which this process occurs, and some of the most common etiological agents that improve our understanding of teratology.

Modern teratology has greatly improved in recent years with advances in new methods in molecular biology, toxicology, animal laboratory science, and genetics, increasing our knowledge of ambient influences. Nevertheless, there is a lot to do to reduce the influence of hazardous intervening agents, whether they target our genetics or not, that can negatively affect pregnancy and induce congenital development disorders, including morphological, biochemical, or behavioral defects.

Certain agents might indeed be related to certain defects, but we have not been able to identify the cause of most congenital defects, which highlights the importance of finding and testing out new genetics techniques and conducting laboratory animal science to unravel the etiology and pathogenicity of each congenital defect.

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Authors and Affiliations

  1. Animal and Veterinary Research Centre (CECAV), UTAD, and Associate Laboratory for Animal and Veterinary Science (AL4Animals), Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences (ECAV), University of Trás-os-Montes e Alto Douro (UTAD), Vila Real, Portugal

    Ana Margarida Calado, Fernanda Seixas & Maria dos Anjos Pires

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  1. Ana Margarida Calado
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  2. Fernanda Seixas
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  3. Maria dos Anjos Pires
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Correspondence to Maria dos Anjos Pires .

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  1. CITAB, Universidade de Trás-os-Montes e Alto Douro, Vila Real, Portugal

    Luís Félix

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Calado, A.M., Seixas, F., Pires, M.d.A. (2024). Updating an Overview of Teratology. In: Félix, L. (eds) Teratogenicity Testing. Methods in Molecular Biology, vol 2753. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3625-1_1

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  • DOI: https://doi.org/10.1007/978-1-0716-3625-1_1

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