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Testing Prepulse Inhibition of Acoustic Startle in Rodents

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Neurobiology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2746))

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Abstract

Prepulse inhibition (PPI) is a measure of sensorimotor gating which is widely used in rodents to study information processing and attention dysfunction. PPI is commonly measured in rats and mice using automated equipment. Here, we present details of a PPI testing protocol extensively used in previous studies. The protocol includes a set pulse-alone startle level and prepulse–pulse combinations with varying interval and intensity. Variations of this protocol can be used depending on the experimental aim or equipment and software version.

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Authors and Affiliations

  1. School of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia

    Maarten van den Buuse & Emily J. Jaehne

Authors
  1. Maarten van den Buuse
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  2. Emily J. Jaehne
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Corresponding author

Correspondence to Maarten van den Buuse .

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Editors and Affiliations

  1. Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Bundoora, VIC, Australia

    Sebastian Dworkin

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© 2024 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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van den Buuse, M., Jaehne, E.J. (2024). Testing Prepulse Inhibition of Acoustic Startle in Rodents. In: Dworkin, S. (eds) Neurobiology. Methods in Molecular Biology, vol 2746. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3585-8_10

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  • DOI: https://doi.org/10.1007/978-1-0716-3585-8_10

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3584-1

  • Online ISBN: 978-1-0716-3585-8

  • eBook Packages: Springer Protocols

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