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Computational Modeling of Mitochondria to Understand the Dynamics of Oxidative Stress

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Mitochondria

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2497))

Abstract

Mitochondria are complex organelles that use catabolic metabolism to produce ATP which is the critical energy source for cell function. Oxidative phosphorylation by the electron transport chain, which receives reducing equivalents (NADH and FADH2) from the tricarboxylic acid cycle, also produces reactive oxygen species (ROS) as a by-product at complex I and III. ROS play a significant role in health and disease. In order to better understand this process, a computational model of mitochondrial energy metabolism and the production of ROS has been developed. The model demonstrates the process regulating ROS production and removal and how different energy substrates can affect ROS production.

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Authors and Affiliations

  1. School of Systems Biology, George Mason University, Fairfax, VA, USA

    Rashmi Kumar & Mohsin S. Jafri

  2. Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, USA

    Mohsin S. Jafri

Authors
  1. Rashmi Kumar
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  2. Mohsin S. Jafri
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Correspondence to Mohsin S. Jafri .

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Editors and Affiliations

  1. Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA

    Namrata Tomar

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Kumar, R., Jafri, M.S. (2022). Computational Modeling of Mitochondria to Understand the Dynamics of Oxidative Stress. In: Tomar, N. (eds) Mitochondria. Methods in Molecular Biology, vol 2497. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2309-1_27

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  • DOI: https://doi.org/10.1007/978-1-0716-2309-1_27

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