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Modelling mitochondrial ROS production by the respiratory chain

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Abstract

ROS (superoxide and oxygen peroxide in this paper) play a dual role as signalling molecules and strong oxidizing agents leading to oxidative stress. Their production mainly occurs in mitochondria although they may have other locations (such as NADPH oxidase in particular cell types). Mitochondrial ROS production depends in an interweaving way upon many factors such as the membrane potential, the cell type and the respiratory substrates. Moreover, it is experimentally difficult to quantitatively assess the contribution of each potential site in the respiratory chain. To overcome these difficulties, mathematical models have been developed with different degrees of complexity in order to analyse different physiological questions ranging from a simple reproduction/simulation of experimental results to a detailed model of the possible mechanisms leading to ROS production. Here, we analyse experimental results concerning ROS production including results still under discussion. We then critically review the three models of ROS production in the whole respiratory chain available in the literature and propose some direction for future modelling work.

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Acknowledgements

This work was supported by the Agence Nationale de la Recherche and the Conseil National de la Recherche Scientifique (CNRS). The authors wish to thank Prof. Michel Rigoulet for careful proofreading of the manuscript and constructive discussions.

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Authors and Affiliations

  1. UMR 5095, IBGC CNRS, 1 Rue Camille Saint-Saëns 33077, Bordeaux Cedex, France

    Jean-Pierre Mazat, Anne Devin & Stéphane Ransac

  2. Université de Bordeaux, 146 Rue Léo-Saignat, 33076, Bordeaux Cedex, France

    Jean-Pierre Mazat & Stéphane Ransac

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  1. Jean-Pierre Mazat
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JPM conceived and coordinated the study and wrote the paper. SR and AD contributed to the writing of the paper, the design of the figures and the analysis of the literature. All authors approved the final version of the manuscript.

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Mazat, JP., Devin, A. & Ransac, S. Modelling mitochondrial ROS production by the respiratory chain. Cell. Mol. Life Sci. 77, 455–465 (2020). https://doi.org/10.1007/s00018-019-03381-1

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