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Evaluation of Mitochondrial Function and Morphology in Drosophila

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Experimental Models of Parkinson’s Disease

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2322))

Abstract

Drosophila melanogaster (Drosophila, fruit fly, or fly) is an important model organism in the studies of molecular genetic analysis and mechanism of Parkinson’s disease (PD), benefiting from its powerful genetic tools and massive available genetic mutants. People have generated different fly models to mimic the inherited PDs and most of them have obvious mitochondrial abnormalities. Here, we describe some common approaches to analyze mitochondrial functions and morphological changes in Drosophila PD models.

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Acknowledgments

This work is supported by the start-up grant of Southern Methodist University to Z.W and the Mustang Fellowship to F.T. We thank Mr. Sree Nallamothu for manuscript proofreading.

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Authors and Affiliations

  1. Department of Biological Sciences, Dedman College of Humanities and Sciences, Southern Methodist University, Dallas, TX, USA

    Yinglu Tang, Foozhan Tahmasebinia & Zhihao Wu

Authors
  1. Yinglu Tang
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  2. Foozhan Tahmasebinia
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  3. Zhihao Wu
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Corresponding author

Correspondence to Zhihao Wu .

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Editors and Affiliations

  1. Department of Research for Parkinson’s Disease, Juntendo University Graduate School of Medicine, Tokyo, Japan

    Yuzuru Imai

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© 2021 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Tang, Y., Tahmasebinia, F., Wu, Z. (2021). Evaluation of Mitochondrial Function and Morphology in Drosophila. In: Imai, Y. (eds) Experimental Models of Parkinson’s Disease. Methods in Molecular Biology, vol 2322. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1495-2_19

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  • DOI: https://doi.org/10.1007/978-1-0716-1495-2_19

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1494-5

  • Online ISBN: 978-1-0716-1495-2

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