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Mitochondrial Dynamics: The Intersection of Form and Function

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Mitochondrial Oxidative Phosphorylation

Part of the book series: Advances in Experimental Medicine and Biology ((volume 748))

Abstract

Mitochondria within a cell exist as a population in a dynamic ­morphological continuum. The balance of mitochondrial fusion and fission dictates a spectrum of shapes from interconnected networks to fragmented individual units. This plasticity bestows the adaptive flexibility needed to adjust to changing cellular stresses and metabolic demands. The mechanisms that regulate mitochondrial dynamics, their importance in normal cell biology, and the roles they play in disease conditions are only beginning to be understood. Dysfunction of mitochondrial dynamics has been identified as a possible disease mechanism in Parkinson’s disease. This chapter will introduce the budding field of mitochondrial dynamics and explore unique characteristics of affected neurons in Parkinson’s disease that increase susceptibility to disruptions in mitochondrial dynamics.

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  1. Department of Pharmacology, and Department of Neuroscience, Boston University School of Medicine, Boston, MA, USA

    Andrew Ferree

  2. Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA, 02118, USA

    Orian Shirihai

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  1. Philipps-Universitaet Marburg, Marburg, 35032, Germany

    Bernhard Kadenbach

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Ferree, A., Shirihai, O. (2012). Mitochondrial Dynamics: The Intersection of Form and Function. In: Kadenbach, B. (eds) Mitochondrial Oxidative Phosphorylation. Advances in Experimental Medicine and Biology, vol 748. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3573-0_2

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