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Coordinating Organismal Metabolism During Protein Misfolding in the ER Through the Unfolded Protein Response

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Coordinating Organismal Physiology Through the Unfolded Protein Response

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 414))

Abstract

The endoplasmic reticulum (ER) is a cellular organelle responsible for folding of secretory and membrane proteins. Perturbance in ER homeostasis caused by various intrinsic/extrinsic stimuli challenges the protein-folding capacity of the ER, leading to an ER dysfunction, called ER stress. Cells have developed a defensive response to adapt and/or survive in the face of ER stress that may be detrimental to cell function and survival. When exposed to ER stress, the cell activates a complex and elaborate signaling network that includes translational modulation and transcriptional induction of genes. In addition to these autonomous responses, recent studies suggest that the stressed tissue secretes peptides or unknown factors that transfer the signal to other cells in the same or different organs, leading the organism as a whole to cope with challenges in a non-autonomous manner. In this review, we discuss the mechanisms by which cells adapt to ER stress challenges autonomously and transfer the stress signal to non-stressed cells in different organs.

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Acknowledgements

We apologize to those who we were unable to reference due to space limitations. RJK is supported by NIH grants DK042394, DK103185, DK110973, and CA198103. This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2015R1D1A1A01058846, NRF-2017033069).

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Authors and Affiliations

  1. Degenerative Diseases Program, Sanford_Burnham_Prebys Medical Discovery Institute, 92037, La Jolla, CA, USA

    Vishwanatha K. Chandrahas & Randal J. Kaufman

  2. Soonchunhyang Institute of Med-bio Science (SIMS), Soonchunhyang University, 31151, Cheonan-si, Chungcheongnam-do, Republic of Korea

    Jaeseok Han

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  1. Vishwanatha K. Chandrahas
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Correspondence to Jaeseok Han or Randal J. Kaufman .

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  1. Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA

    R. Luke Wiseman

  2. Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Cole M. Haynes

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Chandrahas, V.K., Han, J., Kaufman, R.J. (2017). Coordinating Organismal Metabolism During Protein Misfolding in the ER Through the Unfolded Protein Response. In: Wiseman, R., Haynes, C. (eds) Coordinating Organismal Physiology Through the Unfolded Protein Response. Current Topics in Microbiology and Immunology, vol 414. Springer, Cham. https://doi.org/10.1007/82_2017_41

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