Abstract
T, B, and NK lymphocytes are generated from pluripotent hematopoietic stem cells through a successive series of lineage restriction processes. Many regulatory components, such as transcription factors, cytokines/cytokine receptors, and signal transduction molecules orchestrate cell fate specification and determination. In particular, transcription factors play a key role in regulating lineage-associated gene programs. Recent findings suggest the involvement of epigenetic factors in the maintenance of cell fate. Here, we review the early developmental events during lymphocyte lineage determination, focusing on the transcriptional networks and epigenetic regulation. Finally, we also discuss the developmental relationship between acquired and innate lymphoid cells.
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Acknowledgments
We thank Peter Burrows for critical reading of the manuscript. This work is supported in part by grants from the Japan Society for the Promotion of Science (24689042), the Japan Science and Technology Agency, RIKEN IMS-RCAI Young Chief Investigator program and Kanae Foundation for the Promotion of Medical Science.
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Ikawa, T. (2014). Genetic and Epigenetic Control of Early Lymphocyte Development. In: Ellmeier, W., Taniuchi, I. (eds) Transcriptional Control of Lineage Differentiation in Immune Cells. Current Topics in Microbiology and Immunology, vol 381. Springer, Cham. https://doi.org/10.1007/82_2014_370
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