Transcriptional Control of Lineage Differentiation in Immune Cells

  • Wilfried Ellmeier
  • Ichiro Taniuchi

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 381)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Michael Delacher, Lisa Schreiber, David M. Richards, Carla Farah, Markus Feuerer, Jochen Huehn
    Pages 83-124
  3. Darah Christie, Jinfang Zhu
    Pages 125-172
  4. Victoria Male, Hugh J. M. Brady
    Pages 173-187
  5. Swee Heng Milon Pang, Sebastian Carotta, Stephen L. Nutt
    Pages 189-213
  6. Christoph S. N. Klose, Andreas Diefenbach
    Pages 215-255
  7. Izumi Sasaki, Tsuneyasu Kaisho
    Pages 257-278
  8. Michael Bonelli, Han-Yu Shih, Kiyoshi Hirahara, Kentner Singelton, Arian Laurence, Amanda Poholek et al.
    Pages 279-326
  9. Back Matter
    Pages 327-331

About this book


Insights into the regulation of immune cell lineage differentiation and specification as well as into the control of lineage integrity, stability and plasticity are of fundamental importance to understanding innate and adaptive immune responses. In this volume, leading experts provide an up-to-date and comprehensive overview of recent advances in the transcriptional control mechanisms and transcription factor networks that regulate these processes in a variety of different immune cell lineages. The chapters cover the regulation of T versus B cell lineage choice, discuss early B cell development and pre-B cell leukemia prevention, address transcriptional control mechanisms during Th differentiation, in regulatory T cells and iNKT cells, detail genomic switches in helper cell fate choice and plasticity, and highlight the role of the BTB-zinc finger family of transcription factors in T cells. Moreover, the chapters discuss transcriptional networks in DCs, NK cells and in innate lymphoid cells. Together, the reviews illustrate key transcriptional control mechanisms that regulate the development and function of immune cells and demonstrate the impressive advances made over the last decade.


Adaptive immunity Cell fate specification Immune cell differentiation Innate immunity Llineage plasticity Transcription factor networks

Editors and affiliations

  • Wilfried Ellmeier
    • 1
  • Ichiro Taniuchi
    • 2
  1. 1.Medical University of ViennaDivision of Immunobiology, Institute of Immunology, Center of Pathophysiology,Infectiology and ImmunologyViennaAustria
  2. 2.RIKEN Center for Integrative Medical Sciences, IMS,Laboratory for Transcriptional Regulation,YokohamaJapan

Bibliographic information