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HSF1 in RNA Polymerase II Promoter-Proximal Pausing and HSP70 Transcription

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Heat Shock Proteins in Inflammatory Diseases

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Abbreviations

AGO:

Argonaute

ATM:

Ataxia telangiectasia mutated

ChIP-seq:

Chromatin immunoprecipitation sequencing

CTD:

C-terminal domain

DDR:

DNA damage response

DNA-PK:

DNA-dependent protein kinase

DSB:

DNA double strand break

DSIF:

DRB sensitivity-inducing factor

FACT:

Facilitates chromatin transcription

H3K4me3:

H3 trimethylated at lysine 4

HSE:

Heat shock element

HSF1:

Heat shock factor 1

HSP:

Heat shock protein

m7G:

7-methyl guanosine

NELF:

Negative elongation factor

NTP:

Nucleoside triphosphate

NURF:

Nucleosome remodeling factor

PARP:

Poly(ADP)-ribose polymerase

PI3:

Phosphoinositide-3

Pol II:

RNA polymerase II

P-TEFb:

Positive transcription elongation factor b

RNA-seq:

RNA sequencing

SWI/SNF:

Switch/Sucrose non-fermentable

TBP:

TATA box binding protein

TOP2B:

Topoisomerase IIβ

TRIM28:

Tripartite motif-containing 28

Trl:

Trithorax-like

TSS:

Transcription start site

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Acknowledgements

I appreciate S.K. Calderwood at Beth Israel Deaconess Medical Center and D.J. Taatjes at the University of Colorado for their support to study the transcriptional regulation at HSP70. I thank previous and current Bunch lab members in the School of Applied Biosciences at Kyungpook National University (KNU), J. Christ, John, and D.Y. Bunch for their support and loving encouragement. I also thank International Edit for the help with proofreading manuscript. This study was supported by a grant from Korea National Foundation (NRF) (NRF-2017R1D1A1B03030548 and NRF-2020R1F1A1060996) to H.B.

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This article does not contain any studies with human participants performed by any of the authors.

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  1. School of Applied Biosciences, College of Agriculture and Life Sciences, Kyungpook National University, Daeg, Republic of Korea

    Heeyoun Bunch

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  1. Heeyoun Bunch
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Correspondence to Heeyoun Bunch .

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  1. Department of Medicine and Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Medicine and Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

    Punit Kaur

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Bunch, H. (2021). HSF1 in RNA Polymerase II Promoter-Proximal Pausing and HSP70 Transcription. In: Asea, A.A.A., Kaur, P. (eds) Heat Shock Proteins in Inflammatory Diseases. Heat Shock Proteins, vol 22. Springer, Cham. https://doi.org/10.1007/7515_2021_38

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