Skip to main content

Obstructive Sleep Apnea Is Related to Increased Arterial Stiffness in Ultrasound Speckle-Tracking Analysis

  • Chapter
  • First Online:
Respiratory Medicine and Science

Abstract

Obstructive sleep apnea (OSA) is an independent risk factor for atherosclerosis. The aim of our study was to determine arterial stiffness in OSA patients by means of the ultrasound speckle-tracking-based method. Twenty six OSA patients and 17 control subjects were enrolled in the study. The speckle-tracking-based analysis of carotid artery included circumferential strains, circumferential strain rates, radial displacement, and radial strain rates. We found that the global average circumferential strains, circumferential strain rates, and radial displacement were significantly lower in OSA patients compared to controls (2.19 ± 0.30 % vs. 4.17 ± 0.33 %, 0.22 ± 0.03 l/s vs. 0.31 ± 0.02 l/s, 0.10 ± 0.01 mm vs. 0.16 ± 0.02 mm, respectively, p < 0.05 for all). There were no significant differences in radial strain rates between the groups (0.32 ± 0.04 % vs. 0.33 ± 0.01 %). We conclude that OSA is associated with an increased arterial stiffness.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Bjällmark A, Lind B, Peolsson M, Shahgaldi K, Brodin LÅ, Nowak J (2010) Ultrasonographic strain imaging is superior to conventional non-invasive measures of vascular stiffness in the detection of age-dependent differences in the mechanical properties of the common carotid artery. Eur J Echocardiogr 11:630–636

    Article  PubMed  Google Scholar 

  • Catalano M, Lamberti-Castronuovo A, Catalano A, Filocamo D, Zimbalatti C (2011) Two-dimensional speckle-tracking strain imaging in the assessment of mechanical properties of carotid arteries: feasibility and comparison with conventional markers of subclinical atherosclerosis. Eur J Echocardiogr 12:528–535

    Article  PubMed  Google Scholar 

  • Cho IJ, Shim CY, Yang WI, Kim SA, Chang HJ, Jang Y, Chung N, Ha JW (2010) Assessment of mechanical properties of common carotid artery in Takayasu’s arteritis using velocity vector imaging. Circ J 74:1465–1470

    Article  PubMed  Google Scholar 

  • Drager LF, Bortolotto LA, Lorenzi MC, Figueiredo AC, Krieger EM, Lorenzi-Filho G (2005) Early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med 172:613–618

    Article  PubMed  Google Scholar 

  • Herrington DM, Brown WV, Mosca L, Davis W, Eggleston B, Hundley WG, Raines J (2004) Relationship between arterial stiffness and subclinical aortic atherosclerosis. Circulation 110:432–437

    Article  PubMed  Google Scholar 

  • Iguchi A, Yamakage H, Tochiya M, Muranaka K, Sasaki Y, Kono S, Shimatsu A, Satoh-Asahara N (2013) Effects of weight reduction therapy on obstructive sleep apnea syndrome and arterial stiffness in patients with obesity and metabolic syndrome. J Atheroscler Thromb 20:807–820

    Article  PubMed  Google Scholar 

  • Kawasaki T, Fukuda S, Shimada K, Maeda K, Yoshida K, Sunada H, Inanami H, Tanaka H, Jissho S, Taguchi H, Yoshiyama M, Yoshikawa J (2009) Direct measurement of wall stiffness for carotid arteries by ultrasound strain imaging. J Am Soc Echocardiogr 22:1389–1395

    Article  PubMed  Google Scholar 

  • Kim SA, Park SM, Kim MN, Kim YH, Cho DH, Ahn CM, Hong SJ, Lim DS, Shim WJ (2012) The relationship between mechanical properties of carotid artery and coronary artery disease. Eur Heart J Cardiovasc Imaging 13:568–573

    Article  PubMed  Google Scholar 

  • Kohler M, Craig S, Nicoll D, Leeson P, Davies RJ, Stradling JR (2008) Endothelial function and arterial stiffness in minimally symptomatic obstructive sleep apnea. Am J Respir Crit Care Med 178:984–988

    Article  PubMed  Google Scholar 

  • Kumagai T, Kasai T, Kato M, Naito R, Maeno K, Kasagi S, Kawana F, Ishiwata S, Narui K (2009) Establishment of the cardio-ankle vascular index in patients with obstructive sleep apnea. Chest 136:779–786

    Article  PubMed  Google Scholar 

  • Larsson M, Heyde B, Kremer F, Brodin LÅ, D’hooge J (2014) Ultrasound speckle tracking for radial, longitudinal and circumferential strain estimation of the carotid artery: an in vitro validation via sonomicrometry using clinical and high-frequency ultrasound. Ultrasonics 56:399–408

    Article  PubMed  Google Scholar 

  • Liang Y, Zhu H, Friedman MH (2009) The correspondence between coronary arterial wall strain and histology in a porcine model of atherosclerosis. Phys Med Biol 54:5625–5641

    Article  PubMed  Google Scholar 

  • Marshall NS, Wong KK, Liu PY, Cullen SR, Knuiman MW, Grunstein RR (2008) Sleep apnea as an independent risk factor for all-cause mortality: the Busselton health study. Sleep 31:1079–1085

    PubMed  PubMed Central  Google Scholar 

  • Park DW, Kruger GH, Rubin JM, Hamilton J, Gottschalk P, Dodde RE, Shih AJ, Weitzel WF (2013) In vivo vascular wall shear rate and circumferential strain of renal disease patients. Ultrasound Med Biol 39:241–252

    Article  PubMed  PubMed Central  Google Scholar 

  • Saito M, Okayama H, Inoue K, Yoshii T, Hiasa G, Sumimoto T, Nishimura K, Ogimoto A, Higaki J (2012) Carotid arterial circumferential strain by two-dimensional speckle tracking: a novel parameter of arterial elasticity. Hypertens Res 35:897–902

    Article  PubMed  Google Scholar 

  • Schaefer CA, Adam L, Weisser-Thomas J, Pingel S, Vogel G, Klarmann-Schulz U, Nickenig G, Pizarro C, Skowasch D (2015) High prevalence of peripheral arterial disease in patients with obstructive sleep apnoea. Clin Res Cardiol 104:719–726

    Article  CAS  PubMed  Google Scholar 

  • Tuleta I, Pabst S, Juergens UR, Nickenig G, Skowasch D (2011) Obstructive sleep apnoea as a risk factor for atherosclerosis – implication for preventive and personalised treatment. EPMA J 2:39–47

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang D, Ma GS, Wang XY, Lu QQ, Wang Y, Liu NF (2015) Left ventricular subclinical dysfunction associated with myocardial deformation changes in obstructive sleep apnea patients estimated by real-time 3D speckle-tracking echocardiography. Sleep Breath May 24 (Epub ahead of print)

  • Yang WI, Shim CY, Cho IJ, Chang HJ, Choi D, Jang Y, Chung N, Cho SY, Ha JW (2010) Dyssynchronous systolic expansion of carotid artery in patients with Marfan syndrome. J Am Soc Echocardiogr 23:1310–1316

    Article  PubMed  Google Scholar 

  • Yang EY, Brunner G, Dokainish H, Hartley CJ, Taffet G, Lakkis N, Taylor AA, Misra A, McCulloch ML, Morrisett JD, Virani SS, Ballantyne CM, Nagueh SF, Nambi V (2013) Application of speckle-tracking in the evaluation of carotid artery function in subjects with hypertension and diabetes. J Am Soc Echocardiogr 26:901–909

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhang L, Yin JK, Duan YY, Liu X, Xu L, Wang J, Yang YL, Yuan LJ, Cao TS (2014) Evaluation of carotid artery elasticity changes in patients with type 2 diabetes. Cardiovasc Diabetol 13:39. doi:10.1186/1475-2840-13-39

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgments

We gratefully acknowledge Sonotechnik Austria for providing us with the AngE Pro8®. We would also like to thank Dr. R. Fimmers, Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, for his statistical help.

Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to I. Tuleta .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Tuleta, I. et al. (2016). Obstructive Sleep Apnea Is Related to Increased Arterial Stiffness in Ultrasound Speckle-Tracking Analysis. In: Pokorski, M. (eds) Respiratory Medicine and Science. Advances in Experimental Medicine and Biology(), vol 910. Springer, Cham. https://doi.org/10.1007/5584_2016_215

Download citation

Publish with us

Policies and ethics