Abstract
Bariatric surgical procedures, including Roux-en-Y gastric bypass and vertical sleeve gastrectomy, are currently the most effective clinical approaches to achieve a significant and sustainable weight loss. Bariatric surgery also concomitantly improves type 2 diabetes and other metabolic diseases such as nonalcoholic steatohepatitis, cardiovascular diseases, and hyperlipidemia. However, despite the recent exciting progress in the understanding how bariatric surgery works, the underlying molecular mechanisms of bariatric surgery remain largely unknown. Interestingly, bile acids are emerging as potential signaling molecules to mediate the beneficial effects of bariatric surgery. In this review, we summarize the recent findings on bile acids and their activated receptors in mediating the beneficial metabolic effects of bariatric surgery. We also discuss the potential to target bile acid-activated receptors in order to treat obesity and other metabolic diseases.
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Abbreviations
- BA:
-
Bile acid
- FXR:
-
Farnesoid X receptor
- NAFLD:
-
Nonalcoholic fatty liver disease
- NASH:
-
Nonalcoholic steatohepatitis
- RYGB:
-
Roux-en-Y gastric bypass
- T2D:
-
Type 2 diabetes
- TGR5:
-
G protein-coupled bile acid receptor 1 (GPBAR-1, MBAR1, or TGR5)
- VSG:
-
Vertical sleeve gastrectomy
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Acknowledgment
We would like to apologize that we could not include all relevant publications in this review due to the space limitation. This work is supported by National Cancer Institute 2R01CA139158 and John Hench Foundation (W.H.), Shanghai Pujiang Program 17PJ1408800, and the National Natural Science Foundation of China 81773961 (L.D.).
Author Contributions
LD, ZF, and WH wrote the manuscript. YL and TH prepared the figures and table. EZ, LY, and ZW reviewed and revised the manuscript.
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Ding, L. et al. (2019). Targeting Bile Acid-Activated Receptors in Bariatric Surgery. In: Fiorucci, S., Distrutti, E. (eds) Bile Acids and Their Receptors. Handbook of Experimental Pharmacology, vol 256. Springer, Cham. https://doi.org/10.1007/164_2019_229
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