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Interactions between protein kinase C and the T3/T cell antigen receptor complex

  • Chapter
Regulation of Immune Gene Expression

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 13))

Abstract

Activators of protein kinase C induce T cells to become refractory to mitogenic anti-T3 antibodies. A possible mechanism for this unresponsiveness is suggested by the observations that activation of C kinase results in a rapid down regulation of the surface expression of the T3/T cell antigen receptor complex. As well, there is a concommitant phosphorylation of the T3γ and d polypeptides; the γ chain was more extensively phosphorylated than the d chain. No phosphorylation of the T3e chain and the Ti, α and β polypeptides was detected. Evidence was obtained that the T3γ chain is phosphorylated only on serine residues.

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Abbreviations

Ti:

T-lymphocyte antigen receptor

Pdbu:

phorbol 12,13 dibutyrate

OAG:

1-oleoyl-2-acetyl glycerol

Endo-F:

endo-β-N-acetyl glycosaminidase F

FCS:

fetal calf serum

BSA:

bovine serum albumin

SDS/PAGE:

sodium dodecyl-sulphate/polyacrylamide gel electrophoresis

References

  1. Smith, X.A. Immunol.Rev. 51, 337–357 (1980).

    Article  PubMed  CAS  Google Scholar 

  2. Meuer, S.C., Hussey, R.E., Cantrell, D.A., Hodgon, J.C., Schlossman, S.I., Smith, K.A, & Reinherz E.L. Proc. Natl. Acad. Sci. USA 81, 1509–1513 (1984).

    Article  PubMed  CAS  Google Scholar 

  3. Meuer, S.C., Cooper, D.A., Hodgdon, J.C., Hussey, R.E., Fitzgerald, K.A., Schlossman, S.F. & Reinherz, E.L. Science 222, 1239–1241 (1983).

    Article  PubMed  CAS  Google Scholar 

  4. Meuer, S., Acuto, O., Hussey, R., Hodgdon, J., Fitzgerald, K., Schlossman, S. & Reinherz, E. Nature (Lond). 303, 808–819 (1983).

    Article  CAS  Google Scholar 

  5. Meuer, S.C, Fitzgerald, K.A., Hussey, R.E., Hodgdon, J., Schlossman, S.F. & Reinherz, E.L. J.Exp.Med. 157, 705–710 (1983).

    Article  PubMed  CAS  Google Scholar 

  6. Acuto, O., Hussey, R., Fitzgerald, K., Protentis, S., Meuer, S., Schlossman, S. & Reinherz, E. Cell 34, 717–726 (1983).

    Article  PubMed  CAS  Google Scholar 

  7. Borst, J., Alexander, S., Elder, J. & Terhorst, C. J. Biol.Chem. 258, 5135–5141 (1983).

    PubMed  CAS  Google Scholar 

  8. Kanellopoulos, J.M., Wigglesworth, N.M., Owen, M.J. & Crumpton, M.J. EMBO J. 2, 1807–1814 (1983).

    PubMed  CAS  Google Scholar 

  9. Van Wauwe, J.P., De Mey, J.R. & Goosens J.G. J.Immunol. 124, 2708–2712 (1980).

    PubMed  Google Scholar 

  10. Chang, T.W., Kung, P.C., Gingras, S.P. & Goldstein, G. Proc.Natl.Acad.Sci.USA 78, 1805–1808 (1981).

    Article  PubMed  CAS  Google Scholar 

  11. Burns, G.F., Boyd, A.W. & Beverley, P.C.L. J.Immunol. 129, 1451–1457 (1982).

    PubMed  CAS  Google Scholar 

  12. Reinherz, E.L., Meuer, S., Pitzgerald, K.A., Hussey, R.E., Levine, H. & Schlossman S. Cell 30, 735–743 (1982)

    Article  PubMed  CAS  Google Scholar 

  13. Meuer, S., Hodgdon, J., Hussey, R., Protentis, J., Schlossman, S. & Reinherz, E. J.Exp.Med. 158, 899–993 (1983)

    Article  Google Scholar 

  14. Imboden, J.B. & Stobo J.D. J.Exp.Med. 161, 446–456 (1985).

    Article  PubMed  CAS  Google Scholar 

  15. Berridge, M.J. Biochem.J. 220, 345 (1984).

    PubMed  CAS  Google Scholar 

  16. Weiss, A., Imboden, J., Shoback, D. & Stobo, J. Proc. Natl.Acad.Sci. 81, 4169–4174 (1984).

    Article  PubMed  CAS  Google Scholar 

  17. Truneh, A., Albert, P., Goldstein, P. & Schmitt-Yerhurst, A.M. Nature(Lond). 313, 318–320 (1985).

    Article  CAS  Google Scholar 

  18. Nishizuka, I. Nature(Lond). 308, 693–698 (1984).

    Article  CAS  Google Scholar 

  19. Leonard, W.J., Kronk, M., Peffer, N.J., Depper, J.M. & Greene, W.C. Proc.Natl.Acad.Sci. 82, 6281–6285 (1985).

    Article  PubMed  CAS  Google Scholar 

  20. Ando, I., Hariri, G., Wallace, D. & Beverley, P. Eur.J. Immunol. 15, 196–199 (1985).

    Article  PubMed  CAS  Google Scholar 

  21. Bensussan, A., Tourvelle, B., Chen, L.K. Dausset, J. & Sasportes, M. Proc.Natl.Acad.Sci. 82, 6642–6646 (1985).

    Article  PubMed  CAS  Google Scholar 

  22. Beverley, P.C.L. & Callard, R.E. Eur.J.Immunol. 11, 329–334 (1981).

    Article  PubMed  CAS  Google Scholar 

  23. Cantrell, D.A., Davies, A.A. & Crumpton, M.J. Proc.Natl. Acad.Sci. In Press.

    Google Scholar 

  24. Weiss, A. & Stobo, J.D. J.Exp.Med. 160, 1284–1299 (1984)

    Article  PubMed  CAS  Google Scholar 

  25. Boylston, A.W., Goldin, R.D. & Moore, C.S. Eur.J. Immunol. 14, 273–275 (1984)

    Article  PubMed  CAS  Google Scholar 

  26. Rozengurt, E., Rodrigues-Pena, A., Coombs, M. & Sinnet Smith, J. Proc.Natl.Acad.Sci. USA, 81, 5748–5752 (1984).

    Article  PubMed  CAS  Google Scholar 

  27. Barnstable, C.J., Bodmer, W.P., Brown, G., Galfre, G., Milstein, C., Williams A.P. & Ziegler, A. Cell 14, 9–20 (1978).

    Article  PubMed  CAS  Google Scholar 

  28. Shoyab, M., De Lurco, J.E. & Todaro, G.J. Nature 279, 387–391 (1979).

    Article  PubMed  CAS  Google Scholar 

  29. Grunberger, G. & Gordon, P. Am.J.Physiol. 243, E319-E324 (1982).

    PubMed  CAS  Google Scholar 

  30. Stratford May, W. Jacobs, S. & Cuatrecasas, P. Proc. Natl.Acad.Sci. 81, 2016–2020 (1984).

    Article  Google Scholar 

  31. Maffrey, P.G., Friedman B. & Rosner, M.R. J.Biol.Chem. 259, 12502–12507 (1984)

    Google Scholar 

  32. Jacobs, S., Sahyoun, N.E., Saltiel, A.R. & Cuatrecasas, P. Proc.Natl.Acad.Sci.USA 80, 6211–6213 (1983).

    Article  PubMed  CAS  Google Scholar 

  33. Brenner, M.B., Trowbridge, I.S. & Strominger, J.L. Cell 40, 183–190 (1985).

    Article  PubMed  CAS  Google Scholar 

  34. Zanders, E., Lamb, J., Feldman, M., Green, N. & Beverley, P. Nature (Lond). 303, 625–626 (1983).

    Article  CAS  Google Scholar 

  35. Samelson, L.E., Harford, J., Schwartz, R.H. & Klausner, P.D. Proc.Natl.Acad.Sci.USA 82, 1969–1973 (1985).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Imperial Cancer Research Fund, 123, WC2A 3PX, Lincoln’s Inn Fields, London, UK

    D. A. Cantrell, A. A. Davies, G. Krissansen & M. J. Crumpton

Authors
  1. D. A. Cantrell
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  2. A. A. Davies
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  3. G. Krissansen
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  4. M. J. Crumpton
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Marc Feldmann Andrew McMichael

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© 1986 The Humana Press Inc.

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Cantrell, D.A., Davies, A.A., Krissansen, G., Crumpton, M.J. (1986). Interactions between protein kinase C and the T3/T cell antigen receptor complex. In: Feldmann, M., McMichael, A. (eds) Regulation of Immune Gene Expression. Experimental Biology and Medicine, vol 13. Humana Press. https://doi.org/10.1007/978-1-4612-5014-2_11

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  • DOI: https://doi.org/10.1007/978-1-4612-5014-2_11

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9399-6

  • Online ISBN: 978-1-4612-5014-2

  • eBook Packages: Springer Book Archive

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