Definition
Glycerophosphoinositol is an important phospholipid which basically consists of glycerophosphate as basic structure linked to the 1-hydroxyl group of inositol (cyclohexane-1,2,3,4,5,6-hexol) as polar headgroup. In most cases, the stereo chemical form of inositol is myo-d-inositol (Fig. 1). At physiological pH values, the phosphate group is deprotonated, which results in a negatively charged acidic phospholipid. Hydrolysis of a fatty acid leads to monoacylglycerophosphoinositol (Leray 2013).
Chemical structure of 1-palmitoyl-2-linoleoyl-sn-glycero-3-phospho-(1′-myo-inositol)
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References
Gardocki ME, Jani N, Lopes JM. Phosphatidylinositol biosynthesis: biochemistry and regulation. Biochim Biophys Acta. 2005;1735:89–100. doi:10.1016/j.bbalip.2005.05.006.
Leray C. Introduction to lipidomics: from bacteria to man. Boca Raton: CRC Press; 2013.
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Trötzmüller, M. (2016). Glycerophosphoinositol. In: Wenk, M. (eds) Encyclopedia of Lipidomics. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7864-1_35-1
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DOI: https://doi.org/10.1007/978-94-007-7864-1_35-1
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