Skip to main content
SpringerLink
Log in

Free Radicals – An Evolutionary Perspective

  • Reference work entry
  • First Online:
Systems Biology of Free Radicals and Antioxidants

Abstract

This chapter provides an evolutionary perspective on free radical biology. We first explain the concept of life history trade-offs and discuss how the need to manage oxidative stress in an optimal way may be an important mechanism driving the outcome of many of these trade-offs. We examine the different solutions that organisms have evolved to combat the damaging consequences of oxidative stress. We then examine the ways in which balancing investment in such defenses against the consequences of sustaining damage has influenced life history traits such in the context of growth, foraging, diet and activity patterns, sexual signaling, reproduction, and defense against infection.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 1,999.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 2,999.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

A:

Adenine

ATP:

Adenosine-5′-triphosphate

C:

Cytosine

G:

Guanine

T:

Thymine

References

  • Alessio HM (1993) Exercise-induced oxidative stress. Med Sci Sports Exerc 25:218–224

    CAS  PubMed  Google Scholar 

  • Almbro M, Dowling DK, Simmons LW (2011) Effects of vitamin E and beta-carotene on sperm competitiveness. Ecol Lett 14:891–895

    PubMed  Google Scholar 

  • Alonso-Alvarez C, Bertrand S, Faivre B, Chastel O, Sorci G (2007) Testosterone and oxidative stress: the oxidation handicap hypothesis. Proc Biol Sci 274:819–825

    CAS  PubMed Central  PubMed  Google Scholar 

  • Andrews ZB, Horvath TL (2009) Uncoupling protein-2 regulates lifespan in mice. Am J Physiol Endocrinol Metab 296:E621–E627

    CAS  PubMed Central  PubMed  Google Scholar 

  • Balaban RS, Nemoto S, Finkel T (2005) Mitochondria, oxidants, and aging. Cell 120:483–495

    CAS  PubMed  Google Scholar 

  • Banks R, Speakman JR, Selman C (2010) Vitamin E supplementation and mammalian lifespan. Mol Nutr Food Res 54:719–725

    CAS  PubMed  Google Scholar 

  • Beaulieu M, Ropert-Coudert Y, Le Maho Y, Ancel A, Criscuolo F (2010) Foraging in an oxidative environment: relationship between delta(13)C values and oxidative status in Adelie penguins. Proc Biol Sci 277:1087–1092

    CAS  PubMed Central  PubMed  Google Scholar 

  • Beckman KB, Ames BN (1998) The free radical theory of aging matures. Physiol Rev 78:547–581

    CAS  PubMed  Google Scholar 

  • Bergeron P, Careau V, Humphries MM, Reale D, Speakman JR, Garant D (2011) The energetic and oxidative costs of reproduction in a free-ranging rodent. Funct Ecol 25:1063–1071

    Google Scholar 

  • Bielski BHJ, Arudi RL, Sutherland MW (1983) A study of the reactivity of Ho2/O2- with unsaturated fatty-acids. J Biol Chem 258:4759–4761

    CAS  PubMed  Google Scholar 

  • Bize P, Devevey G, Monaghan P, Doligez B, Christe P (2008) Fecundity and survival in relation to resistance to oxidative stress in a free-living bird. Ecology 89:2584–2593

    PubMed  Google Scholar 

  • Bjelland S, Seeberg E (2003) Mutagenicity, toxicity and repair of DNA base damage induced by oxidation. Mutat Res Fundam Mol Mech Mutagen 531:37–80

    CAS  Google Scholar 

  • Blount JD, Metcalfe NB, Arnold KE, Surai PF, Devevey GL, Monaghan P (2003) Neonatal nutrition, adult antioxidant defences and sexual attractiveness in the zebra finch. Proc Biol Sci 270:1691–1696

    CAS  PubMed Central  PubMed  Google Scholar 

  • Boss O, Samec S, PaoloniGiacobino A, Rossier C, Dulloo A, Seydoux J, Muzzin P, Giacobino JP (1997) Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett 408:39–42

    CAS  PubMed  Google Scholar 

  • Bruderer L, Liechti F, Bilo D (2001) Flexibility in flight behaviour of barn swallows (hirundo rustica) and house martins (delichon urbica) tested in a wind tunnel. J Exp Biol 204:1473–1484

    CAS  PubMed  Google Scholar 

  • Buttemer WA, Abele D, Costantini D (2010) From bivalves to birds: oxidative stress and longevity. Funct Ecol 24:971–983

    Google Scholar 

  • Carey HV, Frank CL, Seifert JP (2000) Hibernation induces oxidative stress and activation of NF-kappa B in ground squirrel intestine. J Comp Physiol B 170:551–559

    CAS  PubMed  Google Scholar 

  • Carlos Aledo J, Li Y, Pedro de Magalhaes J, Ruiz-Camacho M, Antonio Perez-Claros J (2011) Mitochondrially encoded methionine is inversely related to longevity in mammals. Aging Cell 10:198–207

    Google Scholar 

  • Casagrande S, Costantini D, Dell'Omo G, Tagliavini J, Groothuis TGG (2012) Differential effects of testosterone metabolites oestradiol and dihydrotestosterone on oxidative stress and carotenoid-dependent colour expression in a bird. Behavioral Ecology and Sociobiology, 66: 1319–1331

    Google Scholar 

  • Catoni C, Schaefer H, Peters A (2008) Fruit for health: the effect of flavonoids on humoral immune response and food selection in a frugivorous bird. Funct Ecol 22:649–654

    Google Scholar 

  • Cohen AA, McGraw KJ, Wiersma P, Williams JB, Robinson W, Robinson TR, Brawn JD, Ricklefs RE (2008) Interspecific associations between circulating antioxidant levels and life-history variation in birds. Am Nat 172:178–193

    PubMed  Google Scholar 

  • Cohen AA, McGraw KJ, Robinson W (2009) Serum antioxidant levels in wild birds vary in relation to diet, season, life history strategy, and species. Oecologia 161:673–683

    PubMed  Google Scholar 

  • Costantini D, Carere C, Caramaschi D, Koolhaas JM (2008) Aggressive and non-aggressive personalities differ in oxidative status in selected lines of mice (Mus musculus). Biology letters 4:119–122

    PubMed Central  PubMed  Google Scholar 

  • Costantini D, Ferrari C, Pasquaretta C, Cavallone E, Carere C, von Hardenberg A. Réale D, (2012) Interplay between plasma oxidative status, cortisol and coping styles in wild alpine marmots, Marmota marmota. The Journal of Experimental Biology, 215: 374–383

    CAS  PubMed  Google Scholar 

  • Costantini D, Dell’Omo G (2006a) Effects of T-cell-mediated immune response on avian oxidative stress. Comp Biochem Physiol A Mol Integr Physiol 145:137–142

    PubMed  Google Scholar 

  • Costantini D, Dell’Omo G (2006b) Environmental and genetic components of oxidative stress in wild kestrel nestlings (Falco tinnunculus). J Comp Physiol B 176:575–579

    CAS  PubMed  Google Scholar 

  • Costantini D, Moller A (2008) Carotenoids are minor antioxidants for birds. Funct Ecol 22:367–370

    Google Scholar 

  • Costantini D, Moller A (2009) Does immune response cause oxidative stress in birds? A meta-analysis. Comp Biochem Physiol A Mol Integr Physiol 153:339–344

    PubMed  Google Scholar 

  • Costantini D, Verhulst S (2009) Does high antioxidant capacity indicate low oxidative stress? Funct Ecol 23:506–509

    Google Scholar 

  • Costantini D, Cardinale M, Carere C (2007) Oxidative damage and anti-oxidant capacity in two migratory bird species at a stop-over site. Comp Biochem Physiol C Toxicol Pharmacol 144:363–371

    PubMed  Google Scholar 

  • Costantini D, Dell’Ariccia G, Lipp HP (2008) Long flights and age affect oxidative status of homing pigeons (Columba livia). J Exp Biol 211:377–381

    CAS  PubMed  Google Scholar 

  • Costantini D, Metcalfe NB, Monaghan P (2010) Ecological processes in a hormetic framework. Ecol Lett 13:1435–1447

    PubMed  Google Scholar 

  • Costantini D, Monaghan P, Metcalfe NB (2011) Biochemical integration of blood redox state in captive zebra finches (Taeniopygia guttata). J Exp Biol 214:1148–1152

    CAS  PubMed  Google Scholar 

  • Criscuolo F, Gonzalez-Barroso MD, Le Maho Y, Ricquier D, Bouillaud F (2005) Avian uncoupling protein expressed in yeast mitochondria prevents endogenous free radical damage. Proc Biol Sci 272:803–810

    CAS  PubMed Central  PubMed  Google Scholar 

  • Criscuolo F, Bize P, Nasir L, Metcalfe NB, Foote CG, Griffiths K, Gault EA, Monaghan P (2009) Real-time quantitative PCR assay for measurement of avian telomeres. J Avian Biol 40:342–347

    Google Scholar 

  • Davies KJA (2000) Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems. IUBMB Life 50:279–289

    CAS  PubMed  Google Scholar 

  • Dotan Y, Lichtenberg D, Pinchuk I (2004) Lipid peroxidation cannot be used as a universal criterion of oxidative stress. Prog Lipid Res 43:200–227

    CAS  PubMed  Google Scholar 

  • Dowling DK, Simmons LW (2009) Reactive oxygen species as universal constraints in life-history evolution. Proc Biol Sci 276:1737–1745

    CAS  PubMed Central  PubMed  Google Scholar 

  • Echtay KS, Esteves TC, Pakay JL, Jekabsons MB, Lambert AJ, Portero-Otin M, Pamplona R, Vidal-Puig AJ, Wang S, Roebuck SJ, Brand MD (2003) A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J 22:4103–4110

    CAS  PubMed Central  PubMed  Google Scholar 

  • Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408:239–247, London

    CAS  PubMed  Google Scholar 

  • Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, LeviMeyrueis C, Bouillaud F, Seldin MF, Surwit RS, Ricquier D, Warden CH (1997) Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet 15:269–272

    CAS  PubMed  Google Scholar 

  • Gomez-Cabrera MC, Domenech E, Vina J (2008) Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radic Biol Med 44:126–131

    CAS  PubMed  Google Scholar 

  • Hails CJ (1979) Comparison of flight energetics in hirundines and other birds. Comp Biochem Physiol A Physiol 63:581–585

    Google Scholar 

  • Hampton MB, Kettle AJ, Winterbourn CC (1998) Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing. Blood 92:3007–3017

    CAS  PubMed  Google Scholar 

  • Harman D (1956) Aging – a theory based on free-radical and radiation-chemistry. J Gerontol 11:298–300

    CAS  PubMed  Google Scholar 

  • Hartley RC, Kennedy MW (2004) Are carotenoids a red herring in sexual display? Trends Ecol Evol 19:353–354

    PubMed  Google Scholar 

  • Helfenstein F, Losdat S, Moller AP, Blount J, Richner H (2010) Sperm of colourful males are better protected against oxidative stress. Ecol Lett 13:213–222

    PubMed  Google Scholar 

  • Herborn KA, Coffey J, Larcombe SD, Alexander L, Arnold KE (2011) Oxidative profile varies with personality in European greenfinches. J Exp Biol 214:1732–1739

    PubMed  Google Scholar 

  • Hermeslima M, Storey KB (1993) Antioxidant defenses in the tolerance of freezing and anoxia by garter snakes. Am J Physiol 265:R646–R652

    CAS  Google Scholar 

  • Hermes-Lima M, Zenteno-Savin T (2002) Animal response to drastic changes in oxygen availability and physiological oxidative stress. Comp Biochem Physiol C Toxicol Pharmacol 133:537–556

    PubMed  Google Scholar 

  • Hermes-Lima M, Storey JM, Storey KB (1998) Antioxidant defenses and metabolic depression. The hypothesis of preparation for oxidative stress in land snails. Comp Biochem Physiol B Biochem Mol Biol 120:437–448

    CAS  PubMed  Google Scholar 

  • Herrero A, Barja G (1997) ADP-regulation of mitochondrial free radical production is different with complex I- or complex II-linked substrates: implications for the exercise paradox and brain hypermetabolism. J Bioenerg Biomembr 29:241–249

    CAS  PubMed  Google Scholar 

  • Horak P, Cohen A (2010) How to measure oxidative stress in an ecological context: methodological and statistical issues. Funct Ecol 24:960–970

    Google Scholar 

  • Horak P, Saks L, Zilmer M, Karu U, Zilmer K (2007) Notes and comments – do dietary antioxidants alleviate the cost of immune activation? An experiment with greenfinches. Am Nat 170:625–635

    PubMed  Google Scholar 

  • Houben JMJ, Moonen HJJ, van Schooten FJ, Hageman GJ (2008) Telomere length assessment: biomarker of chronic oxidative stress? Free Radic Biol Med 44:235–246

    CAS  PubMed  Google Scholar 

  • Hulbert AJ (2005) On the importance of fatty acid composition of membranes for aging. J Theor Biol 234:277–288

    CAS  PubMed  Google Scholar 

  • Hulbert AJ (2008) Explaining longevity of different animals: is membrane fatty acid composition the missing link? Age 30:89–97

    CAS  PubMed Central  PubMed  Google Scholar 

  • Hulbert AJ, Pamplona R, Buffenstein R, Buttemer WA (2007) Life and death: metabolic rate, membrane composition, and life span of animals. Physiol Rev 87:1175–1213

    CAS  PubMed  Google Scholar 

  • Iqbal M, Probert LL, Alhumadi NH, Klandorf H (1999) Protein glycosylation and advanced glycosylated endproducts (AGEs) accumulation: an avian solution? J Gerontol A Biol Sci Med Sci 54:B171–B176

    CAS  PubMed  Google Scholar 

  • Isaksson C, Andersson S (2008) Oxidative stress does not influence carotenoid mobilization and plumage pigmentation. Proc Biol Sci 275:309–314

    CAS  PubMed Central  PubMed  Google Scholar 

  • Isakkson C, Sheldon BC, Uller T (2011) The challenges of integrating oxidative stress into life-history biology. Bioscience 61:194–202

    Google Scholar 

  • Ji LL (1999) Antioxidants and oxidative stress in exercise. Proc Soc Exp Biol Med 222:283–292

    CAS  PubMed  Google Scholar 

  • Jobson RW, Dehne-Garcia A, Galtier N (2010) Apparent longevity-related adaptation of mitochondrial amino acid content is due to nucleotide compositional shifts. Mitochondrion 10:540–547

    CAS  PubMed  Google Scholar 

  • Jones DP (2006) Redefining oxidative stress. Antioxid Redox Signal 8:1865–1879

    CAS  PubMed  Google Scholar 

  • Kern B, Ivanina AV, Piontkivska H, Sokolov EP, Sokolova IM (2009) Molecular characterization and expression of a novel homolog of uncoupling protein 5 (UCP5) from the eastern oyster Crassostrea virginica (Bivalvia: Ostreidae). Comp Biochem Physiol Part D Genomics Proteomics 4:121–127

    PubMed  Google Scholar 

  • Kim SY, Velando A, Sorci G, Alonso-Alvarez C (2010) Genetic correlation between resistance to oxidative stress and reproductive life span in a bird species. Evolution 64:852–857

    CAS  PubMed  Google Scholar 

  • Klandorf H, Rathore DS, Iqbal M, Shi X, Van Dyke K (2001) Accelerated tissue aging and increased oxidative stress in broiler chickens fed allopurinol. Comp Biochem Physiol C Toxicol Pharmacol 129:93–104

    CAS  PubMed  Google Scholar 

  • Lambert AJ, Boysen HM, Buckingham JA, Yang T, Podlutsky A, Austad SN, Kunz TH, Buffenstein R, Brand MD (2007) Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms. Aging Cell 6:607–618

    CAS  PubMed  Google Scholar 

  • Lane N (2002) Oxygen the molecule that made the world. Oxford University Press, Oxford

    Google Scholar 

  • Larcombe SD, Mullen W, Alexander L, Arnold KE (2010) Dietary antioxidants, lipid peroxidation and plumage colouration in nestling blue tits Cyanistes caeruleus. Naturwissenschaften 97:903–913

    CAS  PubMed  Google Scholar 

  • Loschen G, Flohe L, Chance B (1971) Respiratory chain linked H2O2 production in pigeon heart mitochondria. FEBS Lett 18:261–264

    CAS  PubMed  Google Scholar 

  • Magwere T, Pamplona R, Miwa S, Martinez-Diaz P, Portero-Otin M, Brand MD, Partridge L (2006) Flight activity, mortality rates, and lipoxidative damage in drosophila. J Gerontol A Biol Sci Med Sci 61:136–145

    PubMed  Google Scholar 

  • Mark FC, Lucassen M, Poertner HO (2006) Thermal sensitivity of uncoupling protein expression in polar and temperate fish. Comp Biochem Physiol Part D Genomics Proteomics 1:365–374

    PubMed  Google Scholar 

  • Mattson MP, Calabrese EJ (2010) Hormesis: a revolution in biology, toxicology and medicine. Springer, New York

    Google Scholar 

  • Metcalfe NB, Alonso-Alvarez C (2010) Oxidative stress as a life-history constraint: the role of reactive oxygen species in shaping phenotypes from conception to death. Funct Ecol 24:984–996

    Google Scholar 

  • Metcalfe NB, Monaghan P (2013) Does reproduction cause oxidative stress; an open question. Trends Ecol Evol, http://dx.doi.org/10.1016/j.tree.2013.01.015

  • Monaghan P, Charmantier A, Nussey DH, Ricklefs R (2008) The evolutionary ecology of senescence. Funct Ecol 22:371–378

    Google Scholar 

  • Monaghan P, Metcalfe NB, Torres R (2009) Oxidative stress as a mediator of life history trade-offs: mechanisms, measurements and interpretation. Ecol Lett 12:75–92

    PubMed  Google Scholar 

  • Montgomery MK, Hulbert A, Buttemer WA (2011) The long life of birds: the rat-pigeon comparison revisited. PLoS One 6(8):e24138

    CAS  PubMed Central  PubMed  Google Scholar 

  • Mougeot F, Martinez-Padilla J, Webster LMI, Blount JD, Perez-Rodriguez L, Piertney SB (2009) Honest sexual signalling mediated by parasite and testosterone effects on oxidative balance. Proc R Soc B 276:1093–1100

    PubMed Central  PubMed  Google Scholar 

  • Nabholz B, Glemin S, Galtier N (2008) Strong variations of mitochondrial mutation rate across mammals – the longevity hypothesis. Mol Biol Evol 25:120–130

    CAS  PubMed  Google Scholar 

  • Nussey DH, Pemberton JM, Pilkington JG, Blount JD (2009) Life history correlates of oxidative damage in a free-living mammal population. Funct Ecol 23:809–817

    Google Scholar 

  • Olsson M, Wilson M, Uller T, Mott B, Isaksson C, Healey M, Wanger T (2008) Free radicals run in lizard families. Biol Lett 4:186–188

    CAS  PubMed Central  PubMed  Google Scholar 

  • Orr AL, Lohse LA, Drew KL, Hermes-Lima M (2009) Physiological oxidative stress after arousal from hibernation in arctic ground squirrel. Comp Biochem Physiol A Mol Integr Physiol 153:213–221

    PubMed Central  PubMed  Google Scholar 

  • Page MM, Peters CW, Staples JF, Stuart JA (2009) Intracellular antioxidant enzymes are not globally upregulated during hibernation in the major oxidative tissues of the 13-lined ground squirrel Spermophilus tridecemlineatus. Comp Biochem Physiol A Mol Integr Physiol 152:115–122

    PubMed  Google Scholar 

  • Pamplona R (2008) Membrane phospholipids, lipoxidative damage and molecular integrity: a causal role in aging and longevity. Biochim Biophys Acta 1777:1249–1262

    CAS  PubMed  Google Scholar 

  • Pamplona R, Barja G (2007) Highly resistant macromolecular components and low rate of generation of endogenous damage: two key traits of longevity. Ageing Res Rev 6:189–210

    CAS  PubMed  Google Scholar 

  • Pamplona R, Costantini D (2011) Molecular and structural antioxidant defenses against oxidative stress in animals. Am J Physiol Regul Integr Comp Physiol 301:R843–R863

    CAS  PubMed  Google Scholar 

  • Pennycuick CJ (1990) Predicting wingbeat frequency and wavelength of birds. J Exp Biol 150:171–185

    Google Scholar 

  • Perez VI, Buffenstein R, Masamsetti V, Leonard S, Salmon AB, Mele J, Andziak B, Yang T, Edrey Y, Friguet B, Ward W, Richardson A, Chaudhuri A (2009) Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat. Proc Natl Acad Sci USA 106:3059–3064

    CAS  PubMed Central  PubMed  Google Scholar 

  • Peters A, Denk AG, Delhey K, Kempenaers B (2004) Carotenoid-based bill colour as an indicator of immunocompetence and sperm performance in male mallards. J Evol Biol 17:1111–1120

    CAS  PubMed  Google Scholar 

  • Pike TW, Blount JD, Bjerkeng B, Lindstrom J, Metcalfe NB (2007) Carotenoids, oxidative stress and female mating preference for longer lived males. Proc Biol Sci 274:1591–1596

    CAS  PubMed Central  PubMed  Google Scholar 

  • Pike TW, Blount JD, Metcalfe NB, Lindstroem J (2010) Dietary carotenoid availability and reproductive effort influence the age-related decline in performance. Behav Ecol 21:1048–1053

    Google Scholar 

  • Powers SK, Jackson MJ (2008) Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev 88:1243–1276

    CAS  PubMed Central  PubMed  Google Scholar 

  • Raimbault S, Dridi S, Denjean F, Lachuer J, Couplan E, Bouillaud F, Bordas A, Duchamp C, Taouis M, Ricquier D (2001) An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds. Biochem J 353:441–444

    CAS  PubMed Central  PubMed  Google Scholar 

  • Robert KA, Bronikowski AM (2010) Evolution of senescence in nature: physiological evolution in populations of garter snake with divergent life histories. Am Nat 175:E47–E159

    Google Scholar 

  • Salmon AB, Richardson A, Perez VI (2010) Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging? Free Radic Biol Med 48:642–655

    CAS  PubMed Central  PubMed  Google Scholar 

  • Samuels DC (2005) Life span is related to the free energy of mitochondrial DNA. Mech Ageing Dev 126:1123–1129

    CAS  PubMed  Google Scholar 

  • Sanz A, Pamplona R, Barja G (2006) Is the mitochondrial free radical theory of aging intact? Antioxid Redox Signal 8:582–599

    CAS  PubMed  Google Scholar 

  • Schaefer H, McGraw K, Catoni C (2008) Birds use fruit colour as honest signal of dietary antioxidant rewards. Funct Ecol 22:303–310

    Google Scholar 

  • Selman C, Blount D, Nussey DH, Speakman JR (2012) Oxidative damage, ageing and life history evolution: where now? Trends Ecol Evol 27:570–577

    PubMed  Google Scholar 

  • Sheldon BC, Verhulst S (1996) Ecological immunology: costly parasite defences and trade-offs in evolutionary ecology. Trends Ecol Evol 11:317–321

    CAS  PubMed  Google Scholar 

  • Sorci G, Faivre B (2009) Inflammation and oxidative stress in vertebrate host-parasite systems. Philos Trans R Soc Lond B Biol Sci 364:71–83

    PubMed Central  PubMed  Google Scholar 

  • Speakman JR (2005) Body size, energy metabolism and lifespan. J Exp Biol 208:1717–1730

    PubMed  Google Scholar 

  • Talbot DA, Lambert AJ, Brand MD (2004) Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3. FEBS Lett 556:111–115

    CAS  PubMed  Google Scholar 

  • Torres R, Velando A (2007) Male reproductive senescence: the price of immune-induced oxidative damage on sexual attractiveness in the blue-footed booby. J Anim Ecol 76:1161–1168

    PubMed  Google Scholar 

  • von Schantz T, Bensch S, Grahn M, Hasselquist D, Wittzell H (1999) Good genes, oxidative stress and condition-dependent sexual signals. Proc Biol Sci 266:1–12

    Google Scholar 

  • von Zglinicki T, Martin-Ruiz CM (2005) Telomeres as biomarkers for ageing and age-related diseases. Curr Mol Med 5:197–203

    Google Scholar 

  • Weirsma P, Nowak B, Williams JB (2012) Small organ size contributes to the slow pace of life in tropical birds. J Exp Biol 215:1662–1669

    Google Scholar 

  • Weirsma P, Selman C, Speakman JR, Verhulst S (2004) Birds sacrifice oxidative protection for reproduction. Proc Biol Sci 271:S360–S363

    Google Scholar 

  • Yamato M, Shiba T, Yoshida M, Ide T, Seri N, Kudou W, Kinugawa S, Tsutsui H (2007) Fatty acids increase the circulating levels of oxidative stress factors in mice with diet-induced obesity via redox changes of albumin. FEBS J 274:3855–3863

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Biodiversity and Animal Health, Graham Kerr Building, University of Glasgow, Glasgow, G12 8QQ, UK

    Pat Monaghan & David Costantini

Authors
  1. Pat Monaghan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David Costantini
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pat Monaghan .

Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, University of British Colombia, Vancouver, British Columbia, Canada

    Ismail Laher

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Monaghan, P., Costantini, D. (2014). Free Radicals – An Evolutionary Perspective. In: Laher, I. (eds) Systems Biology of Free Radicals and Antioxidants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_25

Download citation

Publish with us

Policies and ethics

Search

Navigation