Definition
The adenosine triphosphate (ATP)-binding cassette (ABC) transporters form the largest family of transmembrane proteins that use ATP-derived energy to transport various substances over cell membranes. Primary-active transporters, driven by energy released from ATP by inherent ATPase activity, that export substrates from the cell against a chemical gradient. Based on the arrangement of the nucleotide-binding domain and the topology of its transmembrane domains, human ABC transporters are classified into seven distinct families (ABC-A to ABC-G), including ABCB1 (P-glycoprotein), ABCC1 (MRP1), ABCC2 (cMOAT, MRP2), ABCC4 (MRP4), and ABCG2 (ABCP, MXR, BCRP). Structural characteristics based on their Walker motif (ATP-binding domain) and their nucleotide-binding folds across the membrane are responsible for their classification into this superfamily. Their localization pattern over the body suggests that they have an...
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(2012) Multidrug resistance. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2393. doi:10.1007/978-3-642-16483-5_3887
(2012) Walker A Motif. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3941. doi:10.1007/978-3-642-16483-5_6228
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Schwab, M. (2014). ABC Drug-Transporters. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_9-2
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DOI: https://doi.org/10.1007/978-3-642-27841-9_9-2
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Publisher Name: Springer, Berlin, Heidelberg
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