Synonyms
Definition
2-Hydroxyoleic acid (2OHOA) is a first-in-class Membrane-Lipid Therapy anticancer drug that specifically activates sphingomyelin (SM) synthase (SMS), a new therapeutic target in the fight against cancer. SMS activation by 2OHOA causes profound membrane lipid remodeling in cancer cells but not in normal cells, altering the organization of membrane microdomains. Normalization of the lipid composition/structure of cancer cell membranes provokes changes in the type and abundance of extrinsic membrane proteins that receive and propagate cell signals. These regulatory effects induce cell cycle arrest, cell differentiation, and programmed cell death of cancer cells.
Characteristics
Structure
2OHOA has 18 C atoms with a cis double bond between carbons 9 and 10 (Fig. 1). It is classified as a monounsaturated omega-9 fatty acid, abbreviated as 18:1n-9 or 18:1 cis-Δ9. It has a hydroxyl moiety on the α-carbon that prevents its rapid...
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References
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Terés S, Lladó V, Higuera M, Barceló-Coblijn G, Martin ML, Noguera-Salva MA, Marcilla-Etxenike A, García-Verdugo JM, Soriano-Navarro M, Saus C, Gómez-Pinedo U, Busquets X, Escribá PV (2012) 2-Hydroxyoleate, a nontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy. Proc Natl Acad Sci U S A 109:8489–8494
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Ibarguren, M., Fernández-García, P., Arbona, L., Busquets, X., Escribá, P.V. (2014). 2-Hydroxyoleic Acid. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_2898-2
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DOI: https://doi.org/10.1007/978-3-642-27841-9_2898-2
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Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27841-9
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