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Aging-Associated Nonmelanoma Skin Cancer: A Role for the Dermis

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Textbook of Aging Skin

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Abstract

The cocktail of sun’s ultraviolet (UVB) rays, and the hands of father time, can significantly increase the risk of skin cancers. However, genetic predisposition, certain skin diseases, and some viral infections can also increase the risk of skin cancers. Nonmelanoma skin cancer (NMSC), including basal cell (BCC) and squamous cell carcinoma (SCC), is thought to be based on a life time exposure to risk factors such as UV radiation combined with little sun protection in that life time. In fact, over 80 % of all skin cancers are found in people over the age of 60. NMSC tends to occur on highly visible areas such as the head, face, and neck. The treatment of these NMSC represents both a significant economic burden to health services and can cause significant morbidity especially as these occur on highly visible areas. Treatment is often invasive surgery which often leads to scaring and affects quality of life. Other treatments are based on chemotherapeutic, immunotherapies that can also affect quality of life. While very effective standard treatments have been developed to treat NMSC, very little is understood about the underlying cellular causes, and as such, alternative methods of treatment have not readily been developed. In this chapter, we explore the mechanisms of UVB-induced effects on skin and exciting new possible methods to treat NMSC.

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Authors and Affiliations

  1. Department of Anatomic Pathology & Histology, Covance CLS, Indianapolis, IN, USA

    Davina A. Lewis

  2. Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA

    Aleksandar Krbanjevic

  3. Departments of Pharmacology & Toxicology and Dermatology, Boonshoft School of Medicine at Wright State University, Dayton, OH, USA

    Jeffrey B. Travers

  4. Departments of Dermatology and Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA

    Dan F Spandau

Authors
  1. Davina A. Lewis
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  2. Aleksandar Krbanjevic
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  3. Jeffrey B. Travers
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  4. Dan F Spandau
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Corresponding author

Correspondence to Dan F Spandau .

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Editors and Affiliations

  1. Procter & Gamble Co., Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Procter & Gamble Co., Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department Dermatology, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Howard I. Maibach

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Lewis, D.A., Krbanjevic, A., Travers, J.B., Spandau, D.F. (2015). Aging-Associated Nonmelanoma Skin Cancer: A Role for the Dermis. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27814-3_58-2

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  • DOI: https://doi.org/10.1007/978-3-642-27814-3_58-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27814-3

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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