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Aging of Epidermal Stem Cells

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Textbook of Aging Skin

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Abstract

This review discusses the changes in stem and progenitor populations that occur with aging and, more specifically, changes of the epidermis that occur with aging. The consensus of opinion is that changes responsible for aging of tissues occur not only in the stem cell pool itself but also in the transit-amplifying cell compartment and in the stem cell environment. In order to study aging of epidermal stem cells, it is essential to isolate epidermal stem cells at the single cell level to better define them at a molecular level. It will also be important to study the intrinsic and extrinsic changes that occur in the environment/niche of the epidermal stem cell with aging.

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Authors and Affiliations

  1. Department of Dermatology and Eli and Edythe Broad, Center of Regeneration Medicine and Stem Cell Research, University of California, Veterans Affairs Medical Center, 1700 Owens street, San Francisco, CA, 94158, USA

    Alexandra Charruyer & Ruby Ghadially

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  1. Alexandra Charruyer
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  2. Ruby Ghadially
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Correspondence to Ruby Ghadially .

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Editors and Affiliations

  1. Procter & Gamble Co., Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Procter & Gamble Co., Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department Dermatology, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Howard I. Maibach

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Charruyer, A., Ghadially, R. (2015). Aging of Epidermal Stem Cells. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27814-3_19-2

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