Abstract
If a metabolic end product or protein is small enough to be filtered at the glomerulus and is neither extensively reabsorbed or secreted, the excretion rate is primarily determined by the glomerular filtration rate (GFR) (Price and Finney 2000), which is considered a sensitive index of functional nephron mass (Newman and Price 1999). Thus, assessment of the plasma level of such a constituent can serve as a biomarker of renal function, and several have been used extensively for this purpose.
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Emeigh Hart, S.G. (2013). Renal System in Safety Pharmacology. In: Vogel, H.G., Maas, J., Hock, F.J., Mayer, D. (eds) Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25240-2_5
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