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Table 14.4 Cellular receptors of various picornaviruses

From: Viruses with Single-Stranded, Positive-Sense RNA Genomes

Genus

Virus

Receptor

Receptor family

Enterovirus

Poliovirus

CD155

Ig superfamily

Coxsackieviruses A13, 18

CAR

Ig superfamily

ICAM-1

Ig superfamily

Coxsackievirus A9

CAR

Ig superfamily

Integrin αvβ3

Ig superfamily

Coxsackieviruses A2, B1, B3; B5

CAR

Ig superfamily

CD55 (DAF)

Ig superfamily

Echovirus (types 1 and 8), Parechovirus (type 1)

Integrin α 3 β 1

Ig superfamily

Echovirus (types 3, 6, 7, 11–13, 21, 24, 25, 29, 30, 33), Enterovirus 70

CD55 (DAF)

Ig superfamily

Rhinovirus

Rhinovirus (major group)

ICAM-1

Ig superfamily

Rhinovirus (minor group)

(V)LDL-receptor

Rhinoviruses A54, A89

Heparan sulphate

Heparan proteoglycan

Hepatovirus

Hepatitis A virus

TIM-1, TIM-3

Ig superfamily

Aphthovirus

Foot-and-mouth disease virus

Integrins α v β 1, α v β 3, α v β 6

Ig superfamily

Heparan sulphate

Heparan proteoglycan

Cardiovirus

Theiler’s encephalomyelitis virus

Unknown

Sialoglycoprotein

Subtype GDVII (neurovirulence)

Heparan sulphate

Heparan proteoglycan

Subtype DA (low neurovirulence)

α2,3-Linked sialic acid

24 kDa Glycoprotein

  1. The respective main receptors are highlighted in bold, and beneath them are the corresponding coreceptors
  2. CAR coxsackievirus and adenovirus receptor, ICAM-1 intercellular adhesion molecule 1, DAF decay-accelerating factor, Ig immunoglobulin TIM T-cell immunoglobulin- and mucin-domain-containing molecule, VLDL very low density lipoprotein