Table 14.17 Functions and properties of arterivirus proteins
From: Viruses with Single-Stranded, Positive-Sense RNA Genomes
Protein | Size (kDa) | Properties | Function |
|---|---|---|---|
GP5/GP7 (LDV) | 24–44 | Glycosylated | Membrane protein; major structural protein neutralizing antibodies, forms heterodimers with M protein, apoptosis induction? |
GP2 | 20–35 | Glycosylated | Membrane protein, minor structural protein, heterotrimer with GP3 and GP4 |
GP3 | 27 | Glycosylated | Membrane protein; minor structural protein, heterotrimer with GP2 und GP4 |
GP4 | 20 | Glycosylated | Membrane protein; minor structural protein, heterotrimer with GP2 und GP3 |
M | 16–20 | – | Membrane protein; major structural protein, forms heterodimers with GP5 and GP7 |
N | 12–15 | Phosphorylated | Nucleocapsid protein; major structural protein, homodimer |
E | 7–8 | Very hydrophobic | Ion channel protein? Homooligomers |
NSP1 | 29 | Papain-like cysteine protease | |
NSP2 | 61 | Cysteine protease | |
NSP4 | 21 | Serine protease, homology to chymotrypsin and 3C proteases of picornaviruses, main protease | |
NSP9 | ? | RNA-dependent RNA polymerase | |
NSP10 | ? | RNA helicase | |
NSP11 | ? | Endoribonuclease (NendoU) | |
MP | ? | Zn2+-binding | ? |