Table 14.10 Function and properties of hepatitis E virus proteins
From: Viruses with Single-Stranded, Positive-Sense RNA Genomes
Protein | Size (kDa) | Properties | Function |
|---|---|---|---|
Capsid protein | 76 | Dimer; signal peptide is cleaved, partially glycosylated | Capsid protein |
Capsid protein | 14.5 | ? | Soluble protein in virions, cleavage product of the 76-kDa capsid protein? |
Methyltransferase/guanylyltransferase | 110 | ? | Capping of genomic and subgenomic RNA molecules |
Protease | ? | Homology to cysteine proteases | Cleaves the precursor of non-structural proteins |
RNA helicase | ? | NTP-binding | Resolution of RNA secondary structures |
RNA-dependent RNA polymerase | ? | ? | Replication Synthesis of subgenomic RNA |
pORF3 | 13.5 | Phosphorylated, homodimer | Associated with cytoskeleton |